Background Numerous investigations demonstrate a novel role of thyroid hormone as a modulator of signal transduction. Protein kinase C (PKC) is critical to the mechanism by which thyroid hormones potentiate both the antiviral and immunomodulatory actions
Krasilnikova Oksana A+2 more
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cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage [PDF]
A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Bate, C, Williams, A
core +2 more sources
Regulation of phospholipase C δ1 by sphingosine
Sphingosine, which is on the pathway of sphingomyelin degradation, activates phospholipase C (PLC) delta1 moderately. In the liposome assay effect of sphingosine on PLC delta1 activity depends on KCl concentration. Stimulation of PLC delta1 by sphingosine increased as the KCl concentration is increased from 0 to 100 mM, and then diminished with the ...
Andrzej Matecki, Tadeusz Pawelczyk
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Synthesis and Evaluation of Fluorogenic Substrates for Phospholipase D and Phospholipase C [PDF]
Fluorogenic analogues of phosphatidylcholine and lysophosphatidylcholine, DDPB and lysoDDPB, were synthesized by an enzyme-assisted strategy. The analogues were evaluated as substrates for phospholipases C and D and lysophospholipase D. DDPB was cleaved by bacterial and plant phospholipase D (PLD) enzymes and represents the first direct fluorogenic ...
Tyler M. Rose, Glenn D. Prestwich
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Molecular analysis of the interaction between cardosin A and phospholipase Dα [PDF]
Cardosin A is an RGD-containing aspartic proteinase from the stigmatic papillae of Cynara cardunculus L. A putative cardosin A-binding protein has previously been isolated from pollen suggesting its potential involvement in pollen2013pistil interaction ...
Bur, Daniel+6 more
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The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L+8 more
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Unraveling the senses of Phytophthora; leads to novel control strategies? [PDF]
Oomycetes cause devastating diseases on plants and animals. They cause major yield losses in many crop plants and their control heavily depends on agrochemicals. This is certainly true for the potato late blight pathogen Phytophthora infestans.
Govers, F.+4 more
core +2 more sources
Regulation of nuclear phospholipase C activity.
A body of evidence, linking inositide-specific phospholipase C (PI-PLC) to the nucleus, is quite extensive. The main isoform in the nucleus is PI-PLCbeta1, whose activity is up-regulated in response to insulin-like growth factor-1 (IGF-1) or insulin stimulation.
MANZOLI, LUCIA+3 more
openaire +6 more sources
Biofilm, proteinase and phospholipase production by Candida albicans isolates from a hospital in Thailand [PDF]
This study aimed to determine biofilm formation, and production of phospholipase and proteinase in 73 clinical isolates of Candida albicans. Biofilms formed in a 96-well plate were quantified by crystal violet staining.
Srisuda Pannanusorn+2 more
doaj
STUDIES ON PHOSPHOLIPASE C FROM MELIA AZADIRACHTA SEEDS [PDF]
3,5- dinitrobenzoyl chloride-pyridine system has been used for dehydration of aldoximes and carboxamides at room ...
doaj +2 more sources