Results 41 to 50 of about 308,555 (173)
Arcanobacterium haemolyticum phospholipase D is genetically and functionally similar to Corynebacterium pseudotuberculosis phospholipase D [PDF]
Infection and Immunity, 1993 Arcanobacterium haemolyticum, a pathogen of the human upper respiratory tract and other systems, has been reported to produce soluble toxins, including a phospholipase D (PLD). We confirmed production of PLD by this organism and cloned and sequenced pld.
J G Songer, W A Cuevas
openaire +2 more sources
Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini
Journal of Lipid Research, 2002 Exogenous ATP stimulated phospholipase D (PLD), but not sphingomyelinase in rat submandibular gland (SMG) acini. PLD activation was dependent upon extracellular Ca2+ and did not involve intracellular Ca2+ mobilization or phosphoinositide-specific ...
Encarnación Pérez-Andrés +11 more
doaj
Phospholipase D and Choline Metabolism
, 2019 Phospholipases D (PLDs) catalyze hydrolysis of the diester bond of phospholipids to generate phosphatidic acid and the free lipid headgroup. In mammals, PLD enzymes comprise the intracellular enzymes PLD1 and PLD2 and possibly the proteins encoded by related genes, as well as a class of cell surface and secreted enzymes with structural homology to ...
Andrew J. Morris, Fredrick O. Onono
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The Role of Phospholipase D in Regulated Exocytosis [PDF]
Journal of Biological Chemistry, 2015 There are a diversity of interpretations concerning the possible roles of phospholipase D and its biologically active product phosphatidic acid in the late, Ca(2+)-triggered steps of regulated exocytosis. To quantitatively address functional and molecular aspects of the involvement of phospholipase D-derived phosphatidic acid in regulated exocytosis ...
Rogasevskaia, Tatiana P. +1 more
openaire +4 more sources
Development of a Three-Dimensional Multiscale Agent-Based Tumor Model: Simulating Gene-Protein Interaction Profiles, Cell Phenotypes & Multicellular Patterns in Brain Cancer [PDF]
arXiv, 2006 Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cell's phenotypic decision to either proliferate or to migrate at a given point in time. Here, we present a novel three-dimensional multiscale agent-based model to simulate this
arxiv
Journal of Lipid Research, 2001 Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts
Bassam Haidar +5 more
doaj
Mapping Complex Networks: Exploring Boolean Modeling of Signal Transduction Pathways [PDF]
arXiv, 2009 In this study, we explored the utility of a descriptive and predictive bionetwork model for phospholipase C-coupled calcium signaling pathways, built with non-kinetic experimental information. Boolean models generated from these data yield oscillatory activity patterns for both the endoplasmic reticulum resident inositol-1,4,5-trisphosphate receptor ...
arxiv
Role of Phospholipase D in G-Protein Coupled Receptor Function
Membranes, 2014 Prolonged agonist exposure of many G-protein coupled receptors induces a rapid receptor phosphorylation and uncoupling from G-proteins. Resensitization of these desensitized receptors requires endocytosis and subsequent dephosphorylation.
Lars-Ove Brandenburg +2 more
doaj +1 more source
On optimality of designs with three distinct eigenvalues [PDF]
arXiv, 2012 Let $\D_{v,b,k}$ denote the family of all connected block designs with $v$ treatments and $b$ blocks of size $k$. Let $d\in\D_{v,b,k}$. The replication of a treatment is the number of times it appears in the blocks of $d$. The matrix $C(d)=R(d)-\frac{1}{k}N(d)N(d)^\top$ is called the information matrix of $d$ where $N(d)$ is the incidence matrix of $d$
arxiv
On the automorphism groups of algebraic bounded domains [PDF]
arXiv, 1994 Let $D$ be a bounded domain in $C^n$. By the theorem of H.~Cartan, the group $Aut(D)$ of all biholomorphic automorphisms of $D$ has a unique structure of a real Lie group such that the action $Aut(D)\times D\to D$ is real analytic. This structure is defined by the embedding $C_v\colon Aut(D)\hookrightarrow D\times Gl_n(C)$, $f\mapsto (f(v), f_{*v ...
arxiv