Results 171 to 180 of about 9,957 (215)

Regulatory Functions of Phospholipase A2

Critical Reviews in Immunology, 1997
Phospholipase A2 (PLA2) plays crucial roles in diverse cellular responses, including phospholipid digestion and metabolism, host defense and signal transduction. PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF ...
Makoto, Murakami, Yoshihito, Nakatani, Gen-Ichi, Atsumi, Keizo, Inoue, Ichiro, Kudo   +4 more
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Extracellular Phospholipase A2

1992
Various lipids have been implicated in signal transduction and as precursors of lipid mediators, among them arachidonic acid (Dennis et al., 1991). Production of the prostaglandins, thromboxanes, and prostacyclins via the cyclooxygenase pathway, as well as the production of the leukotrienes and lipoxins via the lipoxygenase pathway, all depend on the ...
E A, Dennis, R A, Deems, L, Yu
openaire   +2 more sources

Phospholipase A2

2015
Phospholipase A2s (PLA2s) are a group of enzymes that hydrolyze the sn-2 position of phospholipids to generate fatty acids and lysophospholipids, which serve as lipid mediators or their precursors. Mammalian genomes encode genes for more than 30 PLA2s or related enzymes, which are subdivided into several groups on the basis of their structures ...
Makoto Murakami, Yoshitaka Taketomi
openaire   +1 more source

Phospholipase A2

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of eicosanoids, lipid mediators derived from arachidonic acid, such as prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A(2) enzymes in providing arachidonic acid to the ...
Bruno L, Diaz, Jonathan P, Arm
openaire   +2 more sources

Phospholipase A2 receptor: a regulator of biological functions of secretory phospholipase A2

Prostaglandins & Other Lipid Mediators, 2002
The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family that includes the mannose receptor. PLA2R regulates a variety of biological responses elicited by specific types of secretory PLA2s (sPLA2s).
Kohji, Hanasaki, Hitoshi, Arita
openaire   +2 more sources

Inhibition of phospholipase A2 and phospholipase C by polyamines

Archives of Biochemistry and Biophysics, 1978
Abstract The polyamines spermine, spermidine, and putrescine inhibit the activity of phospholipase A2 (Naja naja) and phospholipase C (Clostridium welchii) on phospholipid vesicles and mitochondrial membranes as sources of substrate phospholipids. The inhibitory effect is highest for spermine and lowest for putrescine.
A M, Sechi, L, Cabrini, L, Landi, P, Pasquali, G, Lenaz   +4 more
openaire   +2 more sources

Serum phospholipase A2 in dengue

Journal of Infection, 1997
Group II phospholipase A2 is an enzyme involved in the pathologies of various inflammatory diseases, including infections. We measured the concentration of group II phospholipase A2 in sera of 49 patients suffering from dengue, virus serotype 3, during a recent epidemic in The Cook Islands.
T J, Nevalainen, W, Losacker
openaire   +2 more sources

Mechanisms of inhibition of phospholipase A2

Biochemical Pharmacology, 1980
Abstract Differential scanning calorimetry (d.s.c.) and assays of phospholipase A2 activity were used as tools to distinguish between drugs which interact with the phospholipids and those which interact directly with the enzyme. Cholesterol lowered the transition temperature (tc) and reduced the heat absorbed at transition and inhibited phospholipase
C, Vigo, G P, Lewis, P J, Piper
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Phospholipase A2, an in vivo immunomodulator

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1990
Arachidonic acid (AA) can be released from membrane phospholipids by the action of phospholipase A2 (PLA2). There is evidence that unsaturated fatty acids, particularly AA, released from membrane phospholipids are required to activate the respiratory burst of macrophages.
A, Bravo Cuellar, F, Homo-Delarche, S, Orbach-Arbouys   +2 more
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Phospholipase A2 inhibitors in development

Expert Opinion on Investigational Drugs, 1997
To date, three isoforms of phospholipase A2 (PLA2) have been identified. Of these, the two Ca2+-dependent isoforms, secretory (sPLA2) and cytosolic phospholipase A2 (cPLA2), are targets for new anti-inflammatory drugs. The catalytic mechanisms and functions of the third isoform, Ca2+-independent cytosolic phospholipase A2 (iPLA2), are unknown at ...
U, Tibes, W G, Friebe
openaire   +2 more sources