Results 161 to 170 of about 271,068 (255)

Multiomics analyses revealed the roles of the epithelial–mesenchymal transition and novel early candidate diagnostic biomarkers in neonatal necrotising enterocolitis

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
In infants with necrotising enterocolitis (NEC), excessive inflammation and epithelial cell death promote the epithelial–mesenchymal transition (EMT), leading to damage to intestinal barriers and the translocation of bacteria and toxins. In addition, inflamed epithelia release cytokines to strengthen the inflammatory response.
Xiao‐Chen Liu, Guo‐Bin Liu, Chen Cheng, Jin Zhu, Fei‐Fan Chen, Ying Ji, Yu‐Ni Zhang, Xiao‐Lin Yan, Qing Wang, Xin‐Yu Li, Qing Ai, Yuan Shi, Yu He   +12 more
wiley   +1 more source

Insights into the antiviral activity of phospholipases A₂ (PLA₂s) from snake venoms. [PDF]

Int J Biol Macromol, 2020
Teixeira SC, Borges BC, Oliveira VQ, Carregosa LS, Bastos LA, Santos IA, Jardim ACG, Melo FF, Freitas LM, Rodrigues VM, Lopes DS.   +10 more
europepmc   +1 more source

Testicular toll with viral intrusion: Molecular insights into the impact of chronic HIV infection on male fertility

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
The molecular mechanisms contributing to impaired fertility in HIV+ males remain poorly defined. Using a human immunodeficiency virus (HIV) transgenic (Tg) rat model, we demonstrate key structural and functional sperm regulators including cation channel of sperm (CatSper)1–4 channels and mitochondrial biogenesis genes were markedly downregulated ...
Tousif Ahmed Hediyal, Elizabeth M. Stone, Omar Shukri, Victoria L. Schaal, Amin Foroughi‐Nezhad, Murali Devanaboyina, Josef S. Crenshaw, Amir Elrefaie, Sree Kolli, Camryn N. Davis, Dinesh Pradhan, Sowmya V. Yelamanchili, Gurudutt Pendyala   +12 more
wiley   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source

Secreted Phospholipases A2: Drivers of Inflammation and Cancer. [PDF]

Int J Mol Sci
Hidalgo I, Sorolla MA, Sorolla A, Salud A, Parisi E.   +4 more
europepmc   +1 more source

Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications

Food Frontiers, Volume 7, Issue 5, September 2026.
The dietary sources of taurine, as well as its protective effects and mechanisms in metabolism‐related diseases and metabolic disorder–associated ocular and cerebral injuries. ABSTRACT Taurine (Tau) is a sulfur‐containing amino acid prevalent in animal tissues and primarily acquired through dietary sources.
Xiaojie Ma, Zhijian Rao, Lifang Zheng
wiley   +1 more source

New Insights into the Bioenergetic and Immunomodulatory Properties of Phospholipases A₂ from <i>Bothrops diporus</i> Venom. [PDF]

Toxins (Basel)
Sasovsky DJ, Oliveira AK, Silva DT, Ojeda GA, Almarza C, Lomonte B, Fox JW, Urra FA, Bustillo S.   +8 more
europepmc   +1 more source

Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A₂ and Cytotoxins. [PDF]

Front Pharmacol, 2020
Pucca MB, Ahmadi S, Cerni FA, Ledsgaard L, Sørensen CV, McGeoghan FTS, Stewart T, Schoof E, Lomonte B, Auf dem Keller U, Arantes EC, Çalışkan F, Laustsen AH.   +12 more
europepmc   +1 more source

Comparative Effects of Different Sugar Substitutes in a Mice Model of Type 2 Diabetes Induced Renal Injury

Food Frontiers, Volume 7, Issue 5, September 2026.
Different sugar substitutes attenuate type 2 diabetes–induced renal injury via modulation of metabolic and MAPK signaling pathways. ABSTRACT The global incidence of diabetic kidney disease (DKD) due to type 2 diabetes is rising and is becoming one of the most threatening complications.
Yilin Bian, Bin Wang, Sha Liu, Huaxue Huang, Wenjun Xiao   +4 more
wiley   +1 more source

Proteomics and life-history variability of Endogenous Phospholipases A2 Inhibitors (PLIs) in Bothrops jararaca plasma. [PDF]

PLoS One
Serino-Silva C, Bittencourt Rodrigues CF, Miyamoto JG, Hatakeyama DM, Kavazoi VK, Da Rocha MMT, Tanaka AS, Tashima AK, de Morais-Zani K, Grego KF, Tanaka-Azevedo AM.   +10 more
europepmc   +1 more source