Results 1 to 10 of about 18,478 (212)

Phosphorylation-Mediated Molecular Pathway Changes in Human Pituitary Neuroendocrine Tumors Identified by Quantitative Phosphoproteomics

Cells, 2021
To investigate the biological role of protein phosphorylation in human nonfunctional pituitary neuroendocrine tumors (NF-PitNETs), proteins extracted from NF-PitNET and control tissues were analyzed with tandem mass tag (TMT)-based quantitative ...
Jiajia Li, Siqi Wen, Biao Li, Na Li, Xianquan Zhan   +4 more
doaj   +1 more source

A novel strategy to uncover specific GO terms/phosphorylation pathways in phosphoproteomic data in Arabidopsis thaliana

BMC Plant Biology, 2021
Background Proteins are the workforce of the cell and their phosphorylation status tailors specific responses efficiently. One of the main challenges of phosphoproteomic approaches is to deconvolute biological processes that specifically respond to an ...
Denise S. Arico, Paula Beati, Diego L. Wengier, Maria Agustina Mazzella   +3 more
doaj   +1 more source

Phosphoproteome Dynamics of Streptomyces rimosus during Submerged Growth and Antibiotic Production

mSystems, 2022
Streptomyces rimosus is an industrial streptomycete, best known as a producer of oxytetracycline, one of the most widely used antibiotics. Despite the significant contribution of Streptomyces species to the pharmaceutical industry, most omics analyses ...
Ela Šarić, Gerry A. Quinn, Nicolas Nalpas, Tina Paradžik, Saša Kazazić, Želimira Filić, Maja Šemanjski, Paul Herron, Iain Hunter, Boris Maček, Dušica Vujaklija   +10 more
doaj   +1 more source

Phosphoproteomic Analysis of the Jejunum Tissue Response to Colostrum and Milk Feeding in Dairy Calves during the Passive Immunity Period

Animals, 2022
Improvements in the feeding of calves are of increasing importance for the development of the dairy industry. While colostrum is essential for the health of newborn calves, knowledge of protein phosphorylation alterations in neonatal calves that are fed ...
Xiaowei Zhao, Yunxia Qi, Tao Wu, Guanglong Cheng   +3 more
doaj   +1 more source

The Importance of Protein Phosphorylation for Signaling and Metabolism in Response to Diel Light Cycling and Nutrient Availability in a Marine Diatom

Biology, 2020
Diatoms are major contributors to global primary production and their populations in the modern oceans are affected by availability of iron, nitrogen, phosphate, silica, and other trace metals, vitamins, and infochemicals.
Maxine H. Tan, Sarah R. Smith, Kim K. Hixson, Justin Tan, James K. McCarthy, Adam B. Kustka, Andrew E. Allen   +6 more
doaj   +1 more source

Global signalling network analysis of luminal T47D breast cancer cells in response to progesterone

Frontiers in Endocrinology, 2022
BackgroundBreast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit the external signal from the cell membrane ...
Roni H. G. Wright, Roni H. G. Wright, Viviana Vastolo, Javier Quilez Oliete, José Carbonell-Caballero, Miguel Beato, Miguel Beato   +6 more
doaj   +1 more source

Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome

mSphere, 2020
Protein kinases are important mediators of signal transduction in cellular pathways, and calcium-dependent protein kinases (CDPKs) compose a unique class of calcium-dependent kinases present in plants and apicomplexans, including Plasmodium parasites ...
Karin Blomqvist, Michaela Helmel, Chengqi Wang, Sabrina Absalon, Tetanya Labunska, Rachel M. Rudlaff, Swamy Adapa, Rays Jiang, Hanno Steen, Jeffrey D. Dvorin   +9 more
doaj   +1 more source

Phosphoproteomic Analysis Reveals Rio1-Related Protein Phosphorylation Changes in Response to UV Irradiation in Sulfolobus islandicus REY15A

Frontiers in Microbiology, 2020
DNA damage response (DDR) in eukaryotes is largely regulated by protein phosphorylation. In archaea, many proteins are phosphorylated, however, it is unclear how the cells respond to DNA damage through global protein phosphorylation.
Qihong Huang, Zijia Lin, Pengju Wu, Jinfeng Ni, Yulong Shen   +4 more
doaj   +1 more source

Suberoylanilide Hydroxamic Acid (SAHA) Treatment Reveals Crosstalk Among Proteome, Phosphoproteome, and Acetylome in Nasopharyngeal Carcinoma Cells

Frontiers in Genetics, 2022
Suberoylanilide hydroxamic acid (SAHA), a famous histone deacetylase (HDAC) inhibitor, has been utilized in clinical treatment for cutaneous T-cell lymphoma.
Huichao Huang, Huichao Huang, Ying Fu, Yankun Duan, Ye Zhang, Miaolong Lu, Zhuchu Chen, Zhuchu Chen, Maoyu Li, Maoyu Li, Yongheng Chen, Yongheng Chen   +11 more
doaj   +1 more source

Estimating the total number of phosphoproteins and phosphorylation sites in eukaryotic proteomes [PDF]

, 2017
Background: Phosphorylation is the most frequent post-translational modification made to proteins and may regulate protein activity as either a molecular digital switch or a rheostat.
Amoutzias, Grigoris D, Chaliotis, Anargyros, Kyriakidou, Pelagia, Oliver, Stephen G, Van de Peer, Yves, Vlastaridis, Panayotis   +5 more
core   +2 more sources