Results 41 to 50 of about 18,478 (212)
Frontiers in Microbiology, 2018 The large clostridial glucosylating toxin B (TcdB) is a major virulence factor of the nosocomial pathogen Clostridioides difficile. TcdB inhibits small GTPases by glucosylation leading to impaired downstream signaling.
Johannes Junemann +3 more
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Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria [PDF]
, 2016 In all living organisms, the phosphorylation of proteins modulates various aspects of their functionalities. In eukaryotes, protein phosphorylation plays a key role in cell signaling, gene expression, and differentiation.
Derouiche, Abderahmane +5 more
core +4 more sources
Molecular Oncology, 2010 AbstractReversible protein phosphorylation serves as a basis for regulating a number of cellular processes. Aberrant activation of kinase signaling pathways is commonly associated with several cancers. Recent developments in phosphoprotein/phosphopeptide enrichment strategies and quantitative mass spectrometry have resulted in robust pipelines for high‐
H C, Harsha, Akhilesh, Pandey
openaire +3 more sources
Large‐scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis
Molecular Systems Biology, 2008 Protein phosphorylation regulates a wide range of cellular processes. Here, we report the proteome‐wide mapping of in vivo phosphorylation sites in Arabidopsis by using complementary phosphopeptide enrichment techniques coupled with high‐accuracy mass ...
Naoyuki Sugiyama +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2016 Macrophages represent the primary human host response to pathogen infection and link the immediate defense to the adaptive immune system. Mature tissue macrophages convert from circulating monocyte precursor cells by terminal differentiation in a process
Erik eRichter +4 more
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Global dynamics of Escherichia coli phosphoproteome in central carbon metabolism under changing culture conditions [PDF]
, 2015 Little is known about the role of global phosphorylation events in the control of prokaryote metabolism. By performing a detailed analysis of all protein phosphorylation events previously reported in Escherichia coli, dynamic changes in protein ...
Jacob, Shana +3 more
core +1 more source
Peanut stunt virus and its satellite RNA trigger changes in phosphorylation in N-benthamiana infected plants at the early stage of the infection [PDF]
, 2018 Signaling in host plants is an integral part of a successful infection by pathogenic RNA viruses. Therefore, identifying early signaling events in host plants that play an important role in establishing the infection process will help our understanding ...
De Smet, Ive +4 more
core +2 more sources
Proteomics Analysis of Duck Lung Tissues in Response to Highly Pathogenic Avian Influenza Virus
MicroorganismsDomestic ducks (Anas platyrhynchos domesticus) are resistant to most of the highly pathogenic avian influenza virus (HPAIV) infections. In this study, we characterized the lung proteome and phosphoproteome of ducks infected with the HPAI H5N1 virus (A ...
Periyasamy Vijayakumar +7 more
doaj +1 more source
Global Phosphoproteomics Analysis of IBRS-2 Cells Infected With Senecavirus A
Frontiers in Microbiology, 2022 Phosphorylation is a widespread posttranslational modification that regulates numerous biological processes. Viruses can alter the physiological activities of host cells to promote virus particle replication, and manipulating phosphorylation is one of ...
Jieyi Li +9 more
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Proteogenomic Characterization Reveals Subtype-Specific Therapeutic Potential for HER2-Low Breast Cancer. [PDF]
Adv Sci (Weinh)Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Xu S +20 more
europepmc +2 more sources