Results 1 to 10 of about 12,092 (240)
Metformin inhibits the proliferation of hepatocellular carcinoma cells through inducing ferroptosis analyzed by phosphoproteomics [PDF]
Frontiers in OncologyIntroductionThis study aims to investigate the effects of Metformin on hepatocellular carcinoma cell lines, cell lines and explores the molecular mechanisms underlying.MethodsBel-7402 and HepG2 cells were treated with varying concentrations of Metformin ...
Jihan Sun +7 more
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Applications and prospects of phosphoproteomics in renal disease research [PDF]
PeerJIntroduction Phosphoproteomics, an advanced branch of molecular biology, utilizes specific techniques such as mass spectrometry, affinity chromatography, and bioinformatics analysis to explore protein phosphorylation, shedding light on the cellular ...
XueJia Zheng +8 more
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Proteomics and phosphoproteomics of freshwater mollusk carcasses reveal novel insights as potential food source [PDF]
Frontiers in Cellular and Infection MicrobiologyCipangopaludina chinensis, Radix auricularia, and Nodularia douglasiae are common freshwater mollusks widely distributed in lakes and rivers across China.
Gongzhen Liu +5 more
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Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in Dictyostelium discoideum in Response to Two Different Chemorepellents [PDF]
CellsChemorepulsion mechanisms for eukaryotic cells are poorly understood. We performed proteomics and phosphoproteomics to elucidate how Dictyostelium discoideum responds to its two endogenous chemorepellent signals, the protein AprA and inorganic ...
Salman Zahir Uddin +3 more
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Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver [PDF]
Advanced ScienceColorectal liver metastasis (CRLM) is one of the leading death causes among colorectal cancer (CRC) patients, yet its underlying molecular events remain poorly understood, particularly at the proteomic and phosphoproteomic levels.
Wensi Zhao +20 more
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Cells, 2021 The influence of phosphoproteomics sample preparation methods on the biological interpretation of signaling outcome is unclear. Here, we demonstrate a strong bias in phosphorylation signaling targets uncovered by comparing the phosphoproteomes generated ...
Bharath Sampadi +2 more
doaj +1 more source
Spatiotemporally resolved subcellular phosphoproteomics [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance As one of the most important post-translational modifications, phosphorylation is both highly abundant and dynamically regulated in cells. Characterizing subcellular phosphoproteome with high temporal resolution should shed light on their contributions to diverse cellular processes.
Yanjun Liu +6 more
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Clinical and Translational Medicine, 2022 Background Acetylcholine (ACh) and norepinephrine (NE) are representative neurotransmitters of parasympathetic and sympathetic nerves, respectively, that antagonize each other to coregulate internal body functions.
Yunqiang He +13 more
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Phosphoproteomics technologies and applications in plant biology research
Frontiers in Plant Science, 2015 Protein phosphorylation has long been recognized as an essential mechanism to regulate many important processes of plant life. However, studies on phosphorylation mediated signaling events in plants are challenged with low stoichiometry and dynamic ...
Jinna eLi +6 more
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Frontiers in Nutrition, 2022 Inorganic phosphate (Pi) is an essential nutrient for the human body which exerts adverse health effects in excess and deficit. High Pi-mediated cytotoxicity has been shown to induce systemic organ damage, though the underlying molecular mechanisms are ...
Rebecca Hetz +7 more
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