Results 91 to 100 of about 20,110 (245)

Coactosin Phosphorylation Controls Entamoeba histolytica Cell Membrane Protrusions and Cell Motility

mBio, 2020
Invasion of the colon wall by Entamoeba histolytica during amoebic dysentery entails migration of trophozoites through tissue layers that are rich in extracellular matrix. Transcriptional silencing of the E.
Muhammad M. Hasan, José E. Teixeira, Ying-Wai Lam, Christopher D. Huston   +3 more
doaj   +1 more source

Quantitative and functional post-translational modification proteomics reveals that TREPH1 plays a role in plant thigmomorphogenesis

, 2018
Plants can sense both intracellular and extracellular mechanical forces and can respond through morphological changes. The signaling components responsible for mechanotransduction of the touch response are largely unknown.
Braam, Janet, Chehab, E. Wassim, Dai, Chen, Li, Ning, Liu, Jun, Liu, Shichang, Qing, Dongjin, Ren, Feng, Wang, Kai, Wu, Madeline, Yang, Zhu, Zhang, Weiping, Zheng, Qingsong   +12 more
core   +2 more sources

Identification and characterization of chloroplast casein kinase II from Oryza sativa (rice) [PDF]

, 2017
Plastid casein kinase II is an important regulator of transcription, posttranscriptional processes, and, most likely, different metabolic functions in dicotyledonous species.
Baginsky, Sacha, Ding, Shunhua, Gruissem, Wilhelm, Lu, Congming, Lu, Qingtao, Reiland, Sonja, Roschitzki, Bernd, Rödiger, Anja, Xue, Peng   +8 more
core   +1 more source

Sustained mitogen-activated protein kinase activation reprograms defense metabolism and phosphoprotein profile in Arabidopsis thaliana.

Frontiers in Plant Science, 2014
Mitogen-activated protein kinases (MAPKs) target a variety of protein substrates to regulate cellular signaling processes in eukaryotes. In plants, the number of identified MAPK substrates that control plant defense responses is still limited.
Ines eLassowskat, Christoph eBoettcher, Christoph eBoettcher, Lennart eEschen-Lippold, Dierk eScheel, Justin eLee   +5 more
doaj   +1 more source

Parallel proteomic and phosphoproteomic analyses reveal cellobiose‐dependent regulation of lignocellulase secretion in the filamentous fungus Neurospora crassa

GCB Bioenergy, 2021
High cost of lignocellulases restricts the commercialization of biofuel and bio‐product production from lignocellulosic biomass. Constitutively expressed lignocellulases are considered to degrade cellulose to release small amount of soluble cellodextrins
Bentao Xiong, Linfang Wei, Yifan Wang, Jinyu Li, Xin Liu, Yunheng Zhou, Panpan Du, Hao Fang, Johannes Liesche, Yahong Wei, Jisheng Li, Shaolin Chen   +11 more
doaj   +1 more source

A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. [PDF]

, 2016
Synthetic protein switches controlled with user-defined inputs are powerful tools for studying and controlling dynamic cellular processes. To date, these approaches have relied primarily on intermolecular regulation.
Baker, David, Camp, Nathan D, Cunningham-Bryant, Daniel, Debnath, Jayanta, Dickinson, Miles S, Goreshnik, Inna, Huang, Po-Ssu, Leidal, Andrew M, Maly, Dustin J, Rose, John C, Trevillian, Bridget M, Wolf-Yadlin, Alejandro, Ye, Jordan   +12 more
core   +2 more sources

Oxymatrine Inhibits Epithelial‐Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF‐β1/Smad Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley   +1 more source

Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction

Viruses, 2016
Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective.
Sandra Söderholm, Yu Fu, Lana Gaelings, Sergey Belanov, Laxman Yetukuri, Mikhail Berlinkov, Anton V. Cheltsov, Simon Anders, Tero Aittokallio, Tuula A. Nyman, Sampsa Matikainen, Denis E. Kainov   +11 more
doaj   +1 more source

Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy [PDF]

, 2016
Phospholamban (PLN) plays a central role in Ca2+ homeostasis in cardiac myocytes through regulation of the sarco(endo)plasmic reticulum Ca2+-ATPase 2A (SERCA2A) Ca2+ pump.
Abbasi, C, Buchsbaum, D, Cosme, J, Emili, A, Gramolini, A, Guo, H, Isserlin, R, Kuzmanov, U, Sharma, P   +8 more
core   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source