Results 101 to 110 of about 12,092 (240)

Supplementary Table 1 from Phosphoproteomics Identifies PI3K Inhibitor–selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance

, 2023
Célia Cintas, Thibault Douché, Zahra Dantes, Emmanuelle Mouton‐Barbosa, Marie‐Pierre Bousquet, Coralie Cayron, Silvia Arcucci, Frédéric Pont, Fernanda Ramos‐Delgado, Camille Guyon, Barbara Garmy‐Susini, Paola Cappello, Odile Burlet‐Schiltz, Emilio Hirsch, Anne Gomez‐Brouchet, Benoît Thibault, Maximilian Reichert, Julie Guillermet‐Guibert   +17 more
openalex   +1 more source

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

ATPS-28COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS [PDF]

, 2015
Natalie Grinshtein, Constanza Rioseco, David Uehling, Asma M. Aman, Artee Luchman, Donna L. Senger, Steve Robbins, G. Cairncross, Alessandro Datti, Jeffrey L. Wrana, Steve Jones, Marco A. Marra, Mike Moran, Rima Al‐awar, Samuel Weiss, David R. Kaplan   +15 more
openalex   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Phosphoproteomic Techniques and Applications

, 2014
Phosphoproteomic analysis seeks to determine the overall level of protein phosphorylation, as a result of kinase and phosphatase activity, and determine the identity of proteins which are phosphorylated and the amino acid residues which hold the phosphate group.
Ed, Dudley, A Elizabeth, Bond
openaire   +4 more sources

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

Focus on Phosphoproteomics [PDF]

ELECTROPHORESIS, 2014
Carol, Nilsson, Cheryl, Lichti, Huiling, Liu   +2 more
openaire   +2 more sources

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Hybrid sorghum breeding in China: A historical review and perspectives

Journal of Integrative Plant Biology, EarlyView.
To commemorate the 60th anniversary of the promotion and application of three‐line hybrid sorghum in China, this review highlights pivotal scientific breakthroughs, systematically summarizes the progress in hybrid sorghum breeding and dwarf sorghum breeding in the country, and presents an outlook on the future of sorghum breeding.
Xiangxiang Meng, Lu Li, Qian Qian, Liang Jiang, Zhaosheng Kong   +4 more
wiley   +1 more source

Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome

Proceedings of the National Academy of Sciences
AbstractTyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved post-translational modification that facilitates rapid and reversible modulation of enzyme activity, localization or function. Despite the high abundance of tyrosine phosphorylation events detected on metabolic enzymes in high-throughput mass spectrometry-based studies,
Alissandra L. Hillis, Tigist Tamir, Grace E. Perry, John M. Asara, Jared L. Johnson, Tomer M. Yaron, Lewis C. Cantley, Forest M. White, Alex Toker   +8 more
openaire   +2 more sources