Results 11 to 20 of about 20,110 (245)
Masters of perception: phosphorylation-dependent signaling in plants. [PDF]
New PhytolSummary Plants are masters of perception, reacting to a myriad of biochemical and physical cues in a constantly changing environment. Plants rely on local cell‐based signal processing to perceive and react sufficiently fast to a multitude of stimuli. The ability to respond quickly is crucial for sustaining growth, defense, and metabolism and thereby ...
Roosjen M, Walley JW, Weijers D.
europepmc +2 more sources
Spatiotemporally resolved subcellular phosphoproteomics [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance As one of the most important post-translational modifications, phosphorylation is both highly abundant and dynamically regulated in cells. Characterizing subcellular phosphoproteome with high temporal resolution should shed light on their contributions to diverse cellular processes.
Yanjun Liu +6 more
openaire +2 more sources
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Quantitative plant phosphoproteomics [PDF]
Current Opinion in Plant Biology, 2011 Protein phosphorylation is a major post-translational modification in plants crucial for the regulation of diverse cellular functions. In the early stages of this field, efforts were focused on the qualitative detection, identification, and cataloging of in vivo protein phosphorylation sites.
Kelli G, Kline-Jonakin +2 more
openaire +2 more sources
Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.
PLoS Computational Biology, 2015 Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events.
Pengyi Yang +5 more
doaj +1 more source
Lighting Up T Lymphocyte Signaling with Quantitative Phosphoproteomics
Frontiers in Immunology, 2017 Phosphorylation is the most abundant post-translational modification, regulating several aspects of protein and cell function. Quantitative phosphoproteomics approaches have expanded the scope of phosphorylation analysis enabling the quantification of ...
Candelas Álvarez-Salamero +5 more
doaj +1 more source
Identification of Arginine Phosphorylation in Mycolicibacterium smegmatis
Microbiology Spectrum, 2022 Tuberculosis is a leading cause of worldwide infectious mortality. The prevalence of multidrug-resistant Mycobacterium tuberculosis infections drives an urgent need to exploit new drug targets.
Emmanuel C. Ogbonna +2 more
doaj +1 more source
Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets [PDF]
, 2019 Recuperado de: https://www.biorxiv.org/content/10.1101/310102v1Target of rapamycin (TOR) kinase is a conserved regulator of cell growth whose activity is modulated in response to nutrients, energy and stress.
Couso Liáñez, Inmaculada Concepción +6 more
core +1 more source
Applications and prospects of phosphoproteomics in renal disease research [PDF]
PeerJIntroduction Phosphoproteomics, an advanced branch of molecular biology, utilizes specific techniques such as mass spectrometry, affinity chromatography, and bioinformatics analysis to explore protein phosphorylation, shedding light on the cellular ...
XueJia Zheng +8 more
doaj +2 more sources
Cells, 2021 To investigate the biological role of protein phosphorylation in human nonfunctional pituitary neuroendocrine tumors (NF-PitNETs), proteins extracted from NF-PitNET and control tissues were analyzed with tandem mass tag (TMT)-based quantitative ...
Jiajia Li +4 more
doaj +1 more source