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Quantitative plant phosphoproteomics [PDF]
Current Opinion in Plant Biology, 2011 Protein phosphorylation is a major post-translational modification in plants crucial for the regulation of diverse cellular functions. In the early stages of this field, efforts were focused on the qualitative detection, identification, and cataloging of in vivo protein phosphorylation sites.
Kelli G, Kline-Jonakin +2 more
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Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.
PLoS Computational Biology, 2015 Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events.
Pengyi Yang +5 more
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Frontiers in Plant Science, 2022 Mahonia bealei (M. bealei) is a traditional Chinese medicine containing a high alkaloid content used to treat various diseases. Generally, only dried root and stem are used as medicines, considering that the alkaloid content in M.
Amin Liu +9 more
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Lighting Up T Lymphocyte Signaling with Quantitative Phosphoproteomics
Frontiers in Immunology, 2017 Phosphorylation is the most abundant post-translational modification, regulating several aspects of protein and cell function. Quantitative phosphoproteomics approaches have expanded the scope of phosphorylation analysis enabling the quantification of ...
Candelas Álvarez-Salamero +5 more
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Cell Reports, 2021 Summary: Homeostatic synaptic scaling allows for bi-directional adjustment of the strength of synaptic connections in response to changes in their input.
Kristina Desch +2 more
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Frontiers in Physiology, 2022 Juvenile hormone (JH) regulates insect development and reproduction through both intracellular and membrane signaling, and the two pathways might crosstalk with each other.
Yue Gao +11 more
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Impact of Phosphoproteomics in the Era of Precision Medicine for Prostate Cancer
Frontiers in Oncology, 2018 Prostate cancer is the most common malignancy in men in the United States. While androgen deprivation therapy results in tumor responses initially, there is relapse and progression to metastatic castration-resistant prostate cancer.
Johnny R. Ramroop +5 more
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Bioscience Reports, 2005 Protein phosphorylation is directly or indirectly involved in all important cellular events. The understanding of its regulatory role requires the discovery of the proteins involved in these processes and how, where and when protein phosphorylation takes place.
Roberto, Raggiaschi +2 more
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Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Cell Reports, 2018 Summary: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK ...
Tanveer S. Batth +5 more
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