Results 21 to 30 of about 12,092 (240)

Phosphoproteomic Analysis Reveals Downstream PKA Effectors of AKAP Cypher/ZASP in the Pathogenesis of Dilated Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2021
Background: Dilated cardiomyopathy (DCM) is a major cause of heart failure worldwide. The Z-line protein Cypher/Z-band alternatively spliced PDZ-motif protein (ZASP) is closely associated with DCM, both clinically and in animal models.
Jialan Lv, Zhicheng Pan, Jian Chen, Rui Xu, Dongfei Wang, Jiaqi Huang, Yang Dong, Jing Jiang, Xiang Yin, Hongqiang Cheng, Xiaogang Guo   +10 more
doaj   +1 more source

Highly Efficient Single-Step Enrichment of Low Abundance Phosphopeptides from Plant Membrane Preparations

Frontiers in Plant Science, 2017
Mass spectrometry (MS)-based large scale phosphoproteomics has facilitated the investigation of plant phosphorylation dynamics on a system-wide scale. However, generating large scale data sets for membrane phosphoproteins usually requires fractionation ...
Xu Na Wu, Lin Xi, Heidi Pertl-Obermeyer, Zhi Li, Liang-Cui Chu, Waltraud X. Schulze   +5 more
doaj   +1 more source

Proteomic Analysis of Myocardia Containing the Obscurin R4344Q Mutation Linked to Hypertrophic Cardiomyopathy

Frontiers in Physiology, 2020
Obscurin is a giant cytoskeletal protein with structural and regulatory roles encoded by the OBSCN gene. Recently, mutations in OBSCN were associated with the development of different forms of cardiomyopathies, including hypertrophic cardiomyopathy (HCM).
Li-Yen R. Hu, Aikaterini Kontrogianni-Konstantopoulos   +1 more
doaj   +1 more source

Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa

Frontiers in Cell and Developmental Biology, 2021
Sperm cells are of unique elongated structure and function, the development of which is tightly regulated by the existing proteins and the posttranslational modifications (PTM) of these proteins.
Yongjie Xu, Yongjie Xu, Qiu Han, Chaofeng Ma, Yaling Wang, Pengpeng Zhang, Pengpeng Zhang, Cencen Li, Cencen Li, Xiaofang Cheng, Xiaofang Cheng, Haixia Xu, Haixia Xu   +12 more
doaj   +1 more source

Sperm Phosphoproteome: Unraveling Male Infertility

Biology, 2022
Infertility affects approximately 15% of couples worldwide of childbearing age, and in many cases the etiology of male infertility is unknown. The current standard evaluation of semen is insufficient to establish an accurate diagnosis.
Rebeca Serrano, Luis J. Garcia-Marin, Maria J. Bragado   +2 more
doaj   +1 more source

Interrogating the hidden phosphoproteome [PDF]

PROTEOMICS, 2017
Postgenomic studies continue to highlight the potential clinical importance of protein phosphorylation signaling pathways in drug discovery. Unfortunately, the dynamic range and variable stoichiometry of protein phosphorylation continues to stymie efforts to achieve comprehensive characterization of the human phosphoproteome.
Un-Beom, Kang, William M, Alexander, Jarrod A, Marto   +2 more
openaire   +2 more sources

Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe

Cell Reports, 2018
Summary: Multiple protein kinases regulate cell-cycle progression, of which the cyclin-dependent kinases (CDKs) are thought to act as upstream master regulators.
Matthew P. Swaffer, Andrew W. Jones, Helen R. Flynn, Ambrosius P. Snijders, Paul Nurse   +4 more
doaj   +1 more source

iTRAQ-Based Phosphoproteomic Analysis Exposes Molecular Changes in the Small Intestinal Epithelia of Cats after Toxoplasma gondii Infection

Animals, 2023
Toxoplasma gondii, an obligate intracellular parasite, has the ability to invade and proliferate within most nucleated cells. The invasion and destruction of host cells by T. gondii lead to significant changes in the cellular signal transduction network.
Bintao Zhai, Yu-Meng Meng, Shi-Chen Xie, Jun-Jie Peng, Yang Liu, Yanhua Qiu, Lu Wang, Jiyu Zhang, Jun-Jun He   +8 more
doaj   +1 more source

The proteome and phosphoproteome of circulating extracellular vesicle-enriched preparations are associated with characteristic clinical features in type 1 diabetes

Frontiers in Endocrinology, 2023
IntroductionThere are no validated clinical or laboratory biomarkers to identify and differentiate endotypes of type 1 diabetes (T1D) or the risk of progression to chronic complications.
Anna Casu, Yury O. Nunez Lopez, Gongxin Yu, Christopher Clifford, Anika Bilal, Alejandra M. Petrilli, Heather Cornnell, Elvis Alvarez Carnero, Ananya Bhatheja, Karen D. Corbin, Anton Iliuk, David M. Maahs, Richard E. Pratley   +12 more
doaj   +1 more source

Phosphoproteomics‐based network medicine [PDF]

The FEBS Journal, 2013
One of the major tasks of phosphoproteomics is providing potential biomarkers for either diagnosis or drug targets in medical applications. Because most complex diseases are due to the actions of multiple genes/proteins, the identification of complex phospho‐signatures containing multiple phosphorylation events within phosphoproteomics‐based networks ...
Zexian, Liu, Yongbo, Wang, Yu, Xue
openaire   +2 more sources