Results 21 to 30 of about 20,110 (245)
Estimating the total number of phosphoproteins and phosphorylation sites in eukaryotic proteomes [PDF]
, 2017 Background: Phosphorylation is the most frequent post-translational modification made to proteins and may regulate protein activity as either a molecular digital switch or a rheostat.
Amoutzias, Grigoris D +5 more
core +2 more sources
Cells, 2022 Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses.
Devasahayam Arokia Balaya Rex +7 more
doaj +1 more source
Minimal Information About Sample Preparation for Phosphoproteomics [PDF]
, 2009 This guideline describes parameters and conditions involved in phosphopeptide sample preparation. It covers from the description and preparation of the cells and tissues to the fractionation and specific enrichment of phosphopeptides for MS analysis. The
David Ovelleiro +3 more
core +2 more sources
Impact of Phosphoproteomics in the Era of Precision Medicine for Prostate Cancer
Frontiers in Oncology, 2018 Prostate cancer is the most common malignancy in men in the United States. While androgen deprivation therapy results in tumor responses initially, there is relapse and progression to metastatic castration-resistant prostate cancer.
Johnny R. Ramroop +5 more
doaj +1 more source
Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]
, 2017 The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core +1 more source
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. [PDF]
, 2020 Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified.
Ade, C.P. +18 more
core +1 more source
Bioscience Reports, 2005 Protein phosphorylation is directly or indirectly involved in all important cellular events. The understanding of its regulatory role requires the discovery of the proteins involved in these processes and how, where and when protein phosphorylation takes place.
Roberto, Raggiaschi +2 more
openaire +2 more sources
Cell Reports, 2018 Summary: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK ...
Tanveer S. Batth +5 more
doaj +1 more source
Frontiers in Plant Science, 2017 Mass spectrometry (MS)-based large scale phosphoproteomics has facilitated the investigation of plant phosphorylation dynamics on a system-wide scale. However, generating large scale data sets for membrane phosphoproteins usually requires fractionation ...
Xu Na Wu +5 more
doaj +1 more source
Protein Phosphorylation Changes During Systemic Acquired Resistance in Arabidopsis thaliana
Frontiers in Plant Science, 2021 Systemic acquired resistance (SAR) in plants is a defense response that provides resistance against a wide range of pathogens at the whole-plant level following primary infection.
Qingfeng Zhou +7 more
doaj +1 more source