Results 31 to 40 of about 20,110 (245)

Proceedings of the EuBIC Winter School 2019 [PDF]

, 2019
The 2019 European Bioinformatics Community (EuBIC) Winter School was held from January 15th to January 18th 2019 in Zakopane, Poland. This year’s meeting was the third of its kind and gathered international researchers in the field of (computational ...
Bittremieux, Wout, Bouyssié, David, Dorfer, Viktoria, Kopczynski, Dominik, Locard-Paulet, Marie, Schwämmle, Veit, Soggiu, Alessio, Uszkoreit, Julian, Van Puyvelde, Bart, Willems, Sander   +9 more
core   +4 more sources

Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer [PDF]

, 2014
The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity.
Ailan Guo, Bild, Cai, Carstens, Carvalho, Chen, Chen, Cho, Christos Polytarchou, Conrad, Cooper, Dimitrios Iliopoulos, Duina, Ezell, Filippos Kottakis, Franke, Gowher, Iliopoulos, Ioannis Sanidas, Jianxin Xie, Kalsotra, Kolasinska-Zwierz, Kottakis, Krogan, Kumar, Lan Hu, Luco, Luco, Manning, Maria Hatziapostolou, Maroulakou, Michael J. Comb, Miki, Moore, Moshkin, Orr-Urtreger, Peña, Philip N. Tsichlis, Polytarchou, Scott A. Ezell, Thiery, Tschopp, Wan, Wang, Warzecha, Xie, Yoh, Yoh, Zhang, Zhou   +49 more
core   +1 more source

Interrogating the hidden phosphoproteome [PDF]

PROTEOMICS, 2017
Postgenomic studies continue to highlight the potential clinical importance of protein phosphorylation signaling pathways in drug discovery. Unfortunately, the dynamic range and variable stoichiometry of protein phosphorylation continues to stymie efforts to achieve comprehensive characterization of the human phosphoproteome.
Un-Beom, Kang, William M, Alexander, Jarrod A, Marto   +2 more
openaire   +2 more sources

Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe

Cell Reports, 2018
Summary: Multiple protein kinases regulate cell-cycle progression, of which the cyclin-dependent kinases (CDKs) are thought to act as upstream master regulators.
Matthew P. Swaffer, Andrew W. Jones, Helen R. Flynn, Ambrosius P. Snijders, Paul Nurse   +4 more
doaj   +1 more source

Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors [PDF]

, 2013
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Alcolea, MP, Casado, P, Cutillas, PR, Iorio, F, Joel, S, Rodriguez-Prados, J-C, Saez-Rodriguez, J, Vanhaesebroeck, B   +7 more
core   +2 more sources

Water-Soluble Tomato Extract Fruitflow Alters the Phosphoproteomic Profile of Collagen-Stimulated Platelets

Frontiers in Pharmacology, 2021
Platelet hyperactivity is a risk factor for cardiovascular disease and thrombosis. Recent studies reported that the tomato extract Fruitflow inhibited platelet function, but the molecular mechanism is still unclear.
Shenghao Zhang, Huilian Chen, Chuanbao Li, Beidong Chen, Huan Gong, Yanyang Zhao, Ruomei Qi   +6 more
doaj   +1 more source

Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. [PDF]

, 2018
The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes.
Aftab, Blake T, Ferguson, Ian D, Hann, Byron C, Lam, Christine, Lin, Yu-Hsiu T, Liu, Hui, Liu, Jun O, Mariano, Margarette C, Mitsiades, Constantine S, Murnane, Megan, Smith, Geoffrey A, Taunton, Jack, Wiita, Arun P, Wong, Sandy W   +13 more
core   +2 more sources

Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

eLife, 2016
Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane, followed by endocytosis and recycling of the membrane of synaptic vesicles.
Mahdokht Kohansal-Nodehi, John JE Chua, Henning Urlaub, Reinhard Jahn, Dominika Czernik   +4 more
doaj   +1 more source

Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers

Frontiers in Physiology, 2018
Sea cucumbers exposed to stressful circumstances eviscerate most internal organs, and then regenerate them rapidly under favorable environments. Reversible protein phosphorylation and acetylation are major modifications regulating protein function ...
Lina Sun, Lina Sun, Chenggang Lin, Chenggang Lin, Xiaoni Li, Xiaoni Li, Lili Xing, Lili Xing, Da Huo, Da Huo, Jingchun Sun, Jingchun Sun, Libin Zhang, Libin Zhang, Hongsheng Yang, Hongsheng Yang   +15 more
doaj   +1 more source

An evolutionary perspective on the kinome of malaria parasites [PDF]

, 2012
Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin, Carvalho T. G., Christian Doerig, Eric Talevich, Natarajan Kannan, Wells T. N., Wilson R. J.   +6 more
core   +1 more source