Results 41 to 50 of about 20,110 (245)
A golden age for working with public proteomics data [PDF]
, 2017 Data sharing in mass spectrometry (MS)-based proteomics is becoming a common scientific practice, as is now common in the case of other, more mature 'omics' disciplines like genomics and transcriptomics.
Martens, Lennart +1 more
core +1 more source
Phosphoproteomics‐based network medicine [PDF]
The FEBS Journal, 2013 One of the major tasks of phosphoproteomics is providing potential biomarkers for either diagnosis or drug targets in medical applications. Because most complex diseases are due to the actions of multiple genes/proteins, the identification of complex phospho‐signatures containing multiple phosphorylation events within phosphoproteomics‐based networks ...
Zexian, Liu, Yongbo, Wang, Yu, Xue
openaire +2 more sources
Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer
Cell Reports, 2017 Our understanding of the molecular determinants of cancer is still inadequate because of cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a model system, we analyzed a minute amount of patient-derived epithelial cells from either ...
Chiara Francavilla +11 more
doaj +1 more source
Animals, 2022 Salmonella enterica serovar Enteritidis (S. Enteritidis) is a foodborne pathogen, which can cause great threats to human health through the consumption of contaminated poultry products.
Xiuxiu Miao +7 more
doaj +1 more source
, 2010 Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of ...
Hernandez, Marylens +4 more
core +1 more source
Phosphoproteomics taken to heart [PDF]
Cell Cycle, 2013 The last decade has witnessed a tremendous advance in mass spectrometric instrumentation, sample preparation, and computational proteomics developments that now make it possible to analyze proteins1 or post-translational modifications (PTMs) of proteins2 on a global scale and compare their relative abundance between different cell states.
Lundby, A., Olsen, J.V.
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Neuronal Signaling Involved in Neuronal Polarization and Growth: Lipid Rafts and Phosphorylation
Frontiers in Molecular Neuroscience, 2020 Neuronal polarization and growth are developmental processes that occur during neuronal cell differentiation. The molecular signaling mechanisms involved in these events in in vivo mammalian brain remain unclear.
Michihiro Igarashi +3 more
doaj +1 more source
Cells, 2023 The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates diverse substrates involved in various cellular processes. Here, we found that blocking the kinase activity of DYRK1 inhibited notochord development and lumenogenesis ...
Zhuqing Wang +4 more
doaj +1 more source
Molecular Oncology, 2010 AbstractReversible protein phosphorylation serves as a basis for regulating a number of cellular processes. Aberrant activation of kinase signaling pathways is commonly associated with several cancers. Recent developments in phosphoprotein/phosphopeptide enrichment strategies and quantitative mass spectrometry have resulted in robust pipelines for high‐
H C, Harsha, Akhilesh, Pandey
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Cell Reports, 2021 Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a ...
Lizhi He +11 more
doaj +1 more source