Results 71 to 80 of about 20,110 (245)

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Phosphoproteomic Analysis and Organotypic Cultures for the Study of Signaling Pathways

Bio-Protocol
Signaling pathways are involved in key cellular functions from embryonic development to pathological conditions, with a pivotal role in tissue homeostasis and transformation.
Zilu Ye, Hans H. Wandall, Sally Dabelsteen   +2 more
doaj   +1 more source

Proteomics of industrial fungi: trends and insights for biotechnology [PDF]

, 2010
Filamentous fungi are widely known for their industrial applications, namely, the production of food-processing enzymes and metabolites such as antibiotics and organic acids.
Oliveira, J.M., Graaff, L.H., de
core   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

E. coli Toxin YjjJ (HipH) Is a Ser/Thr Protein Kinase That Impacts Cell Division, Carbon Metabolism, and Ribosome Assembly

mSystems, 2023
Protein Ser/Thr kinases are posttranslational regulators of key molecular processes in bacteria, such as cell division and antibiotic tolerance. Here, we characterize the E.
Fabio Lino Gratani, Till Englert, Payal Nashier, Peter Sass, Laura Czech, Niels Neumann, Sofia Doello, Petra Mann, Rudolf Blobelt, Siegfried Alberti, Karl Forchhammer, Gert Bange, Katharina Höfer, Boris Macek   +13 more
doaj   +1 more source

Editorial [PDF]

, 2016
No abstract ...
Baillie, George S.
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Phosphoproteome Analysis Reveals the Molecular Mechanisms Underlying Deoxynivalenol-Induced Intestinal Toxicity in IPEC-J2 Cells

Toxins, 2016
Deoxynivalenol (DON) is a widespread trichothecene mycotoxin that commonly contaminates cereal crops and has various toxic effects in animals and humans.
Zhi-Qi Zhang, Song-Bo Wang, Rui-Guo Wang, Wei Zhang, Pei-Long Wang, Xiao-Ou Su   +5 more
doaj   +1 more source

Effect of Praziquantel on Schistosoma mekongi Proteome and Phosphoproteome

Pathogens, 2020
Schistosoma mekongi causes schistosomiasis in southeast Asia, against which praziquantel (PZQ) is the only treatment option. PZQ resistance has been reported, thus increasing the requirement to understand mechanism of PZQ.
Peerut Chienwichai, Sumate Ampawong, Poom Adisakwattana, Tipparat Thiangtrongjit, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Onrapak Reamtong   +7 more
doaj   +1 more source

Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells. [PDF]

, 2018
Deregulated signal transduction and energy metabolism are hallmarks of cancer and both play a fundamental role in tumorigenesis. While it is increasingly recognised that signalling and metabolism are highly interconnected, the underpinning mechanisms of ...
Costa, Ana SH, Frezza, Christian, Gonçalves, Emanuel, Johnson, Timothy Isaac, Machado, Daniel, Saez-Rodriguez, Julio, Sciacovelli, Marco, Tran, Maxine Gia Binh   +7 more
core   +2 more sources