Results 81 to 90 of about 12,092 (240)

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

Oxymatrine Inhibits Epithelial‐Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF‐β1/Smad Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley   +1 more source

Supplementary Figures from Phosphoproteomics Identifies PI3K Inhibitor–selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance

, 2023
Célia Cintas, Thibault Douché, Zahra Dantes, Emmanuelle Mouton‐Barbosa, Marie‐Pierre Bousquet, Coralie Cayron, Silvia Arcucci, Frédéric Pont, Fernanda Ramos‐Delgado, Camille Guyon, Barbara Garmy‐Susini, Paola Cappello, Odile Burlet‐Schiltz, Emilio Hirsch, Anne Gomez‐Brouchet, Benoît Thibault, Maximilian Reichert, Julie Guillermet‐Guibert   +17 more
openalex   +1 more source

Phosphoproteomic analysis on ovarian follicles reveals the involvement of LSD1 phosphorylation in Chicken follicle selection [PDF]

, 2023
Yanhong Zhang, Qiuyue Chen, Yuanyuan Guo, Li Kang, Yi Sun, Yunliang Jiang   +5 more
openalex   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Supplementary Methods from Phosphoproteomics Identifies PI3K Inhibitor–selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance

, 2023
Célia Cintas, Thibault Douché, Zahra Dantes, Emmanuelle Mouton‐Barbosa, Marie‐Pierre Bousquet, Coralie Cayron, Silvia Arcucci, Frédéric Pont, Fernanda Ramos‐Delgado, Camille Guyon, Barbara Garmy‐Susini, Paola Cappello, Odile Burlet‐Schiltz, Emilio Hirsch, Anne Gomez‐Brouchet, Benoît Thibault, Maximilian Reichert, Julie Guillermet‐Guibert   +17 more
openalex   +1 more source

Phosphoproteomic Characterization and Kinase Signature Predict Response to Venetoclax Plus 3+7 Chemotherapy in Acute Myeloid Leukemia [PDF]

, 2023
Jie Jin, Shangyu Hou, Yiyi Yao, Miao Liu, Liping Mao, Min Yang, Hongyan Tong, Tao Zeng, Jinyan Huang, Yinghui Zhu, Huafeng Wang   +10 more
openalex   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats

Frontiers in Cardiovascular Medicine
Background and aimsIschemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after
Ahmed Elmahdy, Ahmed Elmahdy, Aaron Shekka Espinosa, Aaron Shekka Espinosa, Yalda Kakaei, Yalda Kakaei, Tetiana Pylova, Tetiana Pylova, Abhishek Jha, Abhishek Jha, Ermir Zulfaj, Maryna Krasnikova, Maryna Krasnikova, Amin Al-Awar, Amin Al-Awar, Zahra Sheybani, Zahra Sheybani, Valentyna Sevastianova, Valentyna Sevastianova, Evelin Berger, Amirali Nejat, Linnea Molander, Linnea Molander, Erik Axel Andersson, Erik Axel Andersson, Elmir Omerovic, Elmir Omerovic, Shafaat Hussain, Shafaat Hussain, Björn Redfors, Björn Redfors, Björn Redfors   +31 more
doaj   +1 more source

Quantitative Phosphoproteomic Analysis of Soybean Root Hairs Inoculated with Bradyrhizobium japonicum [PDF]

, 2012
Tran H. Nguyen, Laurent Brechenmacher, Joshua Aldrich, Therese RW Clauss, Marina Gritsenko, Kim Hixson, Marc Libault, Kiwamu Tanaka, Feng Yang, Qiuming Yao, Ljiljana Paša‐Tolić, Dong Xu, Henry T. Nguyen, Gary Stacey   +13 more
openalex   +1 more source