Results 121 to 130 of about 38,220 (259)

Integrierte chemo‐enzymatische Synthese des mRNA‐Impfstoff‐Bausteins N1‐Methylpseudouridintriphosphat

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
Pseudouridin‐5'‐triphosphat (ΨTP) und sein N1‐methyliertes Derivat (m1ΨTP) sind entscheidende Komponenten in der mRNA‐Impfstofftechnologie. Hier wird ein atomökonomischer, ertragreicher biokatalytischer Weg zur Synthese von ΨTP vorgestellt. Zudem wurde ein neuer chemo‐enzymatischer Weg für die m1ΨTP‐Synthese entwickelt.
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Mycoplasmas and cancer [PDF]

, 2014
The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan, Liekens, Sandra, Vande Voorde, Johan   +2 more
core  

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

Angewandte Chemie International Edition, Volume 64, Issue 34, August 18, 2025.
Pseudouridine‐5′‐triphosphate (ΨTP) and its N1‐methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom‐economic, high‐yielding biocatalytic route for ΨTP synthesis is presented. A new chemoenzymatic route for m1ΨTP synthesis was developed.
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Mutational analysis of primary and advanced chordoma tissue using next‐generation sequencing

Cancer, Volume 131, Issue 16, 15 August 2025.
Abstract Background Chordomas are rare ectodermal bone malignancies derived from transformed notochordal remnants. Histologic variants include conventional (80%–90%), chondroid (5%–15%), and dedifferentiated (2%–8%). Because chordomas are relatively resistant to chemotherapy and radiotherapy, novel targeted agents are needed to expand treatment ...
Josh Chan, Joseph K. Kendal, Zhenfeng Duan, Al Ferreira, Alireza Samiei, Scott D. Nelson, Arun Singh, Elizabeth L. Lord, Brooke Crawford, Nicholas M. Bernthal, Francis J. Hornicek   +10 more
wiley   +1 more source

Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives

Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.
ABSTRACT Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, predicted the ...
Michele Goulart dos Santos, Marie Demonceaux, Lucia Emanueli Schimith, Marine Goux, Claude Solleux, Ana Luiza Muccillo‐Baisch, Bruno Dutra Arbo, Corinne Andre‐Miral, Mariana Appel Hort   +8 more
wiley   +1 more source

Modeling and Optimization of Microwave Vacuum Drying for Pinelliae Rhizoma: Integrating Drying Kinetics, Artificial Neural Networks, and Quality Preservation

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
The peeled Pinellia ternata (Thunb.) Breit tubers were dried with the microwave vacuum drying oven. Then, its drying characteristics, contents of nucleosides, and surface microstructural alterations of dried samples were determined, respectively. Drying parameters were predicted and optimized using four different mathematical models and artificial ...
Pan Wang, Xiaoping Yang, Xiaopeng Huang, Guojun Ma, Shidong Zhang, Siqi Wang, Ming Wang, Zewen Zhu, Yanrui Xu, ZePeng Zang, Xu Liu   +10 more
wiley   +1 more source

Genetic Variants Affect Distinct Metabolic Pathways in Pediatric Multisystem Inflammatory Syndrome and Severe COVID‐19

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT The coronavirus disease 2019 (COVID‐19) pandemic has triggered a global health crisis, with over 700 million confirmed cases and at least 7 million deaths reported by early 2024. Children are less vulnerable to severe SARS‐CoV‐2 infection than adults and typically experience milder respiratory symptoms.
Alysson Henrique Urbanski, Flávia Cristina de Paula Freitas, Tiago Minuzzi Freire da Fontoura Gomes, Michelle Orane Schemberger, Bárbara Carvalho Santos dos Reis, Flavia Amêndola Anísio de Carvalho, Roberta Soares Faccion, Lucas de Almeida Machado, Deborah Antunes dos Santos, Daniela Prado Cunha, Margarida dos Santos Salú, Daniella Campelo Batalha Cox Moore, Mayra Marinho Presibella, Juliana Fontes Noguchi, Henrique Lira Borges, Lais Kimie Tomiura, Luiza Silva de Castro, Letícia Graziela Costa Santos, Esdras Matheus Gomes da Silva, Vinícius Da Silva Coutinho Parreira, Luis Gustavo Morello, Fabricio Klerynton Marchini, Maria Regina Tizzot, Mauricio Marcondes Ribas, Gilberto Pascolat, Carmen Australia Paredes Marcondes Ribas, Fábio Fernandes da Rocha Vicente, Alexandre Rossi Paschoal, Rubens Cat, Benilton de Sá Carvalho, Jaqueline Carvalho de Oliveira, Marcus F. Oliveira, Luiz Lehmann Coutinho, Acácia Maria Lourenço Francisco Nasr, Irina Nastassja Riediger, Jeanine Marie Nardin, Liya Regina Mikami, Ana Carolina Ramos Guimarães, Patricia Savio de Araujo‐Souza, Arnaldo Prata‐Barbosa, Zilton Farias Meira de Vasconcelos, Helisson Faoro, Hellen Geremias dos Santos, Fabio Passetti   +43 more
wiley   +1 more source

Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Nucleotides are the building blocks of DNA and RNA. They also play essential roles in various other biological processes, including protein glycosylation, ribosome biogenesis, and cytoskeletal function. The significance of the regulation of nucleotide metabolism has recently gained more attention in many physiological and pathological contexts,
Lara Dsouza, Zhilong Yang
wiley   +1 more source

Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer

MedComm, Volume 6, Issue 8, August 2025.
Mitochondrial fission and fusion are key processes in maintaining cellular health. Fission is driven by proteins like, Fis‐1, which recruits DRP‐1, to facilitate the division of mitochondria. Fusion, however, is mediated by mitofusion 1(MFN1), mitofusion 2(MFN2), and optic atrophy 1 (OPA1), which work together to merge mitochondria, allowing functional
Saloni Malla, Rabin Neupane, Saloni Sood, Noor Hussein, Mariam Abou‐Dahech, David Terrero, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +8 more
wiley   +1 more source

Astrocyte in Neurological Disease: Pathogenesis and Therapy

MedComm, Volume 6, Issue 8, August 2025.
This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang, Aoyang Long, Lingjia Hao, Zilin Shi, Mengqi Zhang   +4 more
wiley   +1 more source