Results 11 to 20 of about 38,432 (313)

Tri-Cyclic Nucleobase Analogs and Their Ribosides as Substrates of Purine-Nucleoside Phosphorylases. II Guanine and Isoguanine Derivatives

Molecules, 2019
Etheno-derivatives of guanine, O6-methylguanine, and isoguanine were prepared and purified using standard methods. The title compounds were examined as potential substrates of purine-nucleoside phosphorylases from various sources in the reverse ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Michał Górka, Agnieszka Bzowska, Beata Wielgus-Kutrowska   +4 more
doaj   +2 more sources

The chemoenzymatic synthesis of clofarabine and related 2′-deoxyfluoroarabinosyl nucleosides: the electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases

Beilstein Journal of Organic Chemistry, 2014
Two approaches to the synthesis of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (1, clofarabine) were studied. The first approach consists in the chemical synthesis of 2-deoxy-2-fluoro-α-D-arabinofuranose-1-phosphate (12a, 2FAra-1P) via ...
Ilja V. Fateev, Konstantin V. Antonov, Irina D. Konstantinova, Tatyana I. Muravyova, Frank Seela, Roman S. Esipov, Anatoly I. Miroshnikov, Igor A. Mikhailopulo   +7 more
doaj   +2 more sources

Biosynthesis of Arabinoside from Sucrose and Nucleobase via a Novel Multi-Enzymatic Cascade [PDF]

Biomolecules
Arabinoside and derived nucleoside analogs, a family of nucleoside analogs, exhibit diverse typically biological activities and are widely used as antibacterial, antiviral, anti-inflammatory, antitumor, and other drugs in clinical and preclinical trials.
Yuxue Liu, Erchu Yang, Xiaojing Zhang, Xiaobei Liu, Xiaoting Tang, Zhenyu Wang, Hailei Wang   +6 more
doaj   +2 more sources

Discovery and Activity Evaluation of Novel Dibenzoxazepinone Derivatives as Glycogen Phosphorylase Inhibitors [PDF]

Molecules
Inhibition of glycogen phosphorylases (GP) has been regarded as a therapeutic strategy for blood glucose control in diabetes. In this study, a series of novel dibenzoxazepinone derivatives was synthesized.
Dongrui Liu, Zhiwei Yan, Youde Wang, Shuai Li, Yachun Guo, Tienan Wang, Jinjia Guo, Liying Zhang   +7 more
doaj   +2 more sources

One-pot synthesis of cellobiose from sucrose using sucrose phosphorylase and cellobiose phosphorylase co-displaying Pichia pastoris as a reusable whole-cell biocatalyst [PDF]

Scientific Reports
Cellobiose has received increasing attention in various industrial sectors, ranging from food and feed to cosmetics. The development of large-scale cellobiose applications requires a cost-effective production technology as currently used methods based on
Kentaro Inokuma, Kiyotsuna Toyohara, Tomoya Hamada, Akihiko Kondo, Tomohisa Hasunuma   +4 more
doaj   +2 more sources

Commonality of Mechanism in Glycoside Hydrolases, Nucleoside Hydrolases, and Phosphorylases: Importance of Side-Chain Conformation Preorganization [PDF]

JACS Au
Po-Sen Tseng, Jonathan C. K. Quirke, W. Jonathan Lin, David Crich   +3 more
doaj   +2 more sources

β-Glucan phosphorylases in carbohydrate synthesis

Applied Microbiology and Biotechnology, 2021
β-Glucan phosphorylases are carbohydrate-active enzymes that catalyze the reversible degradation of β-linked glucose polymers, with outstanding potential for the biocatalytic bottom-up synthesis of β-glucans as major bioactive compounds. Their preference
Zorica Ubiparip, Marc De Doncker, Koen Beerens, Jorick Franceus, T. Desmet   +4 more
semanticscholar   +1 more source

Side Chain Conformation Restriction in the Catalysis of Glycosidic Bond Formation by Leloir Glycosyltransferases, Glycoside Phosphorylases, and Transglycosidases.

ACS Catalysis, 2021
Carbohydrate side chain conformation is an important factor in the control of reactivity at the anomeric center, ie, in the making and breaking of glycosidic bonds, whether chemically or, for hydrolysis, by glycoside hydrolases. In nature glycosidic bond
Jo Quirke, D. Crich
semanticscholar   +1 more source

Diversification of 4ʹ-Methylated Nucleosides by Nucleoside Phosphorylases

ACS Catalysis, 2021
The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies.
Felix Kaspar, M. Seeger, Sarah Westarp, Christoph Köllmann, A. Lehmann, P. Pausch, Sebastian Kemper, P. Neubauer, G. Bange, A. Schallmey, D. Werz, Anke Kurreck   +11 more
semanticscholar   +1 more source

Synthesis of 5-oxymethyl-1,2,4-triazole-3-carboxamides

Тонкие химические технологии, 2022
Objectives. A key step in the synthesis of natural nucleoside analogs is the formation of a glycosidic bond between the carbohydrate fragment and the heterocyclic base. Glycosylation methods differ in terms of regio- and stereoselectivity.
L. E. Grebenkina, A. N. Prutkov, A. V. Matveev, M. V. Chudinov   +3 more
doaj   +1 more source