Results 41 to 50 of about 38,220 (259)

Innovative Agents for Actinic Keratosis and Nanocarriers Enhancing Skin Penetration [PDF]

, 2010
Actinic keratosis and cutaneous squamous cell carcinoma are of increasing importance with aging and increased ultraviolet light exposure in Western societies. Efficient and well-tolerated therapy is still a matter of concern.
Höltje, H.-D., Höltje, M., Korting, Hans Christian, Schäfer-Korting, Monika   +3 more
core   +1 more source

Discovery of solabiose phosphorylase and its application for enzymatic synthesis of solabiose from sucrose and lactose

Scientific Reports, 2022
Glycoside phosphorylases (GPs), which catalyze the reversible phosphorolysis of glycosides, are promising enzymes for the efficient production of glycosides.
Wataru Saburi, Takanori Nihira, Hiroyuki Nakai, Motomitsu Kitaoka, Haruhide Mori   +4 more
doaj   +1 more source

Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylases

Beilstein Journal of Organic Chemistry, 2016
The trans-2-deoxyribosylation of 4-thiouracil (4SUra) and 2-thiouracil (2SUra), as well as 6-azauracil, 6-azathymine and 6-aza-2-thiothymine was studied using dG and E.
Vladimir A. Stepchenko, Anatoly I. Miroshnikov, Frank Seela, Igor A. Mikhailopulo   +3 more
doaj   +1 more source

Anion exchange resins in phosphate form as versatile carriers for the reactions catalyzed by nucleoside phosphorylases

Beilstein Journal of Organic Chemistry, 2020
In the present work, we suggested anion exchange resins in the phosphate form as a source of phosphate, one of the substrates of the phosphorolysis of uridine, thymidine, and 1-(β-ᴅ-arabinofuranosyl)uracil (Ara-U) catalyzed by recombinant E. coli uridine
Julia N. Artsemyeva, Ekaterina A. Remeeva, Tatiana N. Buravskaya, Irina D. Konstantinova, Roman S. Esipov, Anatoly I. Miroshnikov, Natalia M. Litvinko, Igor A. Mikhailopulo   +7 more
doaj   +1 more source

Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases. [PDF]

PLoS ONE, 2012
The hexameric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) displays great potential to produce nucleoside analogues in industry and can be exploited in the development of new anti-tumor gene therapies.
Priscila O de Giuseppe, Nadia H Martins, Andreia N Meza, Camila R dos Santos, Humberto D'Muniz Pereira, Mario T Murakami   +5 more
doaj   +1 more source

The origins and physical roots of life’s dual – metabolic and genetic – nature [PDF]

, 2017
This review paper aims at a better understanding of the origin and physical foundation of life’s dual – metabolic and genetic – nature. First, I give a concise ‘top-down’ survey of the origin of life, i.e., backwards in time from extant DNA/RNA/protein ...
De Tiège, Alexis
core   +2 more sources

Continuous process technology for bottom-up synthesis of soluble cello-oligosaccharides by immobilized cells co-expressing three saccharide phosphorylases

Microbial Cell Factories, 2022
Background Continuous processing with enzyme reuse is a well-known engineering strategy to enhance the efficiency of biocatalytic transformations for chemical synthesis.
Katharina N. Schwaiger, Bernd Nidetzky
doaj   +1 more source

Glycan Phosphorylases in Multi-Enzyme Synthetic Processes

Protein Peptide Letters, 2017
Glycoside phosphorylases catalyse the reversible synthesis of glycosidic bonds by glyco-sylation with concomitant release of inorganic phosphate. The equilibrium position of such reactions can render them of limited synthetic utility, unless coupled with
Giulia Pergolizzi, S. Kuhaudomlarp, E. Kalita, R. Field   +3 more
semanticscholar   +1 more source

QM/MM Study of a Nucleophilic Substitution Reaction Catalyzed by Uridine Phosphorylase from Vibrio cholerae

Crystals, 2023
Uridine phosphorylases are used for biotechnological synthesis of pyrimidine derivatives and, moreover, their substrates and inhibitors are used in medicine.
Alexander A. Lashkov, Polina A. Eistrich-Geller, Valeriya R. Samygina, Sergey V. Rubinsky   +3 more
doaj   +1 more source

Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]

, 2016
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P., Hofer, Anders, Pavlova, Anna, Ranjbarian, Farahnaz, Vodnala, Munender   +4 more
core   +1 more source