Photopharmacology beyond azobenzene photoswitches
Responsive MaterialsPhotopharmacology harnesses photoswitchable molecules to reversibly and precisely modulate biological activities, offering exceptional spatial and temporal control through non‐invasive illumination.
Huichao Guo +5 more
doaj +3 more sources
Photopharmacology reveals high-specificity linkage of Ca2+ entry at TRPC6 nanodomains to NFAT activation in mast cells [PDF]
Frontiers in ImmunologyIntroductionPhotopharmacology has recently emerged as a strategy for high-precision modulation of immune functions. Here we explored efficiency and specificity of interventions based on light-induced TRPC6 activation in the RBL-2H3 mast cell model ...
Denis Krivić +10 more
doaj +2 more sources
Application of photopharmacology in agrochemicals
Advanced Agrochem, 2023 Photopharmacology is a novel technology in drug design that aims at solving poor drug selectivity. This technology is currently in the proof-of-concept phase and relies on the photoactivation or inactivation of photochromic ligands (PCLs) to regulate ...
Wen Fu, Zhong Li, Xusheng Shao
doaj +2 more sources
New Visible-Light-Sensitive Dicyanocoumarin- and COUPY-Based Caging Groups with Improved Photolytic Efficiency [PDF]
MoleculesPhotolabile protecting groups (PPGs), also known as caging groups, are valuable tools in photopharmacology. They enable precise control over the release of bioactive compounds from the corresponding caged compounds at a precisely controlled time and ...
Marta López-Corrales, Vicente Marchán
doaj +2 more sources
Synthesis and Study of Substituted Chalcones Combined with Fluoroazobenzenes—New Photoswitches for Application in Biological Systems [PDF]
MoleculesChalcones have garnered significant research interest due to their various medical bioactivities. Several chalcone compounds have been approved for marketing and clinical use in the treatment of various diseases.
Piotr Tobiasz +5 more
doaj +2 more sources
Photopharmacological modulation of hippocampal local field potential by caged‐glutamate with MicroLED probe [PDF]
Neuropsychopharmacology ReportsAim Photopharmacology is a new technique for modulating biological phenomena through the photoconversion of substances in a specific target region at precise times.
Shogo Okada +7 more
doaj +2 more sources
Precise photopharmacological eradication of metastatic tumor cells
Disease Models & MechanismsABSTRACT Owing to their high efficacy, antimitotic chemotherapeutics are the mainstay for most cancer treatments. However, these drugs do not discriminate between tumor and healthy cells, thus show dose-limiting toxicity and severe adverse effects. To improve treatments, rendering chemotherapeutics tumor-cell specific is highly desirable.
Adam Varady +8 more
doaj +3 more sources
Photopharmacology of Proteolysis-Targeting Chimeras: A New Frontier for Drug Discovery
Frontiers in Chemistry, 2021 Photopharmacology is an emerging field that uses light to precisely control drug activity. This strategy promises to improve drug specificity for reducing off-target effects.
Shenxin Zeng +7 more
doaj +1 more source
Photomodulation Approaches to Overcome Antimicrobial Resistance
Pharmaceuticals, 2023 Photopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs)
Sofia N. Sarabando +4 more
doaj +1 more source
Nanomaterials, 2023 Photopharmacology is a booming research area requiring a new generation of agents possessing simultaneous functions of photoswitching and pharmacophore.
Gulia Bikbaeva +9 more
doaj +1 more source