Results 91 to 100 of about 1,927 (190)

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman   +206 more
wiley   +1 more source

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate
Alzheimer's disease (AD) is one of the most prevalent forms of neurodegenerative disease. Although some controversy exists, β‐amyloid peptide (Aβ) is recognized to play an essential role in the pathophysiology of AD.
Yunhua Zhang, Chengyuan Qian, Yuncong Chen, Weijiang He, Zijian Guo   +4 more
doaj   +1 more source

A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

eLife
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (NAM) of mGlu5 ...
Serena Notartomaso, Nico Antenucci, Mariacristina Mazzitelli, Xavier Rovira, Serena Boccella, Flavia Ricciardi, Francesca Liberatore, Xavier Gomez-Santacana, Tiziana Imbriglio, Milena Cannella, Charleine Zussy, Livio Luongo, Sabatino Maione, Cyril Goudet, Giuseppe Battaglia, Amadeu Llebaria, Ferdinando Nicoletti, Volker Neugebauer   +17 more
doaj   +1 more source

A Chemically Stable Photocaged Noradrenaline. [PDF]

ACS Chem Neurosci
Photoactivatable neurotransmitters provide spatiotemporally precise experimenter control over endogenous receptor activation in living tissue. The resulting optical stimulus-neuronal response relationship provides a sensitive assay that can drive ...
Buczynski SA, Li A, Chang-Weinberg J, Nawsheen SS, Banghart MR.   +4 more
europepmc   +3 more sources

Identification of Methylglyoxal Reactive Proteins with Photocaged Glycating Agents

ChemBioChem, Volume 26, Issue 21, November 8, 2025.
Photocaged methylglyoxal (PC‐MGO) derivatives enable studying protein glycation under mild conditions. The active glycating agents can be released in the protein solution by irradiating the sample with UV light. Compared to the earlier reported chemically activated MGO probes, the photocaged probes are more potent.
Saskia Sokoliova, I. Raluca Sardaru, Franciszek P. Warguła, Jos H. Hermans, Hjalmar P. Permentier, Peter L. Horvatovich, Martin D. Witte   +6 more
wiley   +1 more source

Controlling Biological Pathways with Photopharmacology [PDF]

Biophysical Journal, 2016
Light can be used to control biological events with unmatched temporal and spatial precision. A case in point is optogenetics, which relies on natural photoreceptors that employ retinal, flavins or tetrapyrrols as chromophores. Recently, the incorporation of synthetic photoswitches, such as azobenzenes, into naturally “blind” native receptors has been ...
openaire   +1 more source

Review of Multifunctional Neural Probe

Advanced Materials Interfaces, Volume 12, Issue 21, November 10, 2025.
Modern multifunctional neural probes for brain‐machine interfaces extend beyond basic electrical functions to incorporate chemical and optical modalities. This review explores recent advances in multifunctional probes developed for neural signal acquisition and stimulation, highlighting how these innovations enhance the precision of brain activity ...
Ziqi Jia, Yong Kyu Yoon
wiley   +1 more source

Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo

Beilstein Journal of Organic Chemistry, 2020
Background: Hemithioindigo is a promising molecular photoswitch that has only recently been applied as a photoswitchable pharmacophore for control over bioactivity in cellulo. Uniquely, in contrast to other photoswitches that have been applied to biology,
Alexander Sailer, Franziska Ermer, Yvonne Kraus, Rebekkah Bingham, Ferdinand H. Lutter, Julia Ahlfeld, Oliver Thorn-Seshold   +6 more
doaj   +1 more source

Hemithioindigos for cellular tubulin photopharmacology: From proof of concept to near-quantitatively photoswitchable tools with single-cell precision [PDF]

, 2022
Microtubules (MTs) are hollow polymeric tubes formed of α/β-tubulin heterodimers that are in a constant dynamic equilibrium between growth and shrinkage. MTs are an essential constituent of the cytoskeleton and so are critical in many cellular processes,
Sailer, Alexander
core  

Mechanistic Insight into Para‐Substituent Control of Thermal Half‐Lives in Arylazopyrazole Photoswitches

Angewandte Chemie, Volume 137, Issue 43, October 20, 2025.
Herein we provide an overview of photochromic and photophysical properties of a broad variety of arylazo‐1,3,5‐trimethylpyrazole photoswitches, including the influence of 23 different para‐substituents. Measured half‐lives correlated in a Hammet plot are rationalized by density functional theory calculations, revealing the underlying thermal ...
Katharina Schlögl, Nadja K. Singer, Dominik Dreier, Hubert Kalaus, Rafaela C. O. Conceição, Marko D. Mihovilovic, Leticia González   +6 more
wiley   +1 more source