Results 101 to 110 of about 1,927 (190)
Phototherapy and photopharmacology.
The Yale journal of biology and medicine, 1986 The activation of 8-methoxypsoralen (8-MOP) by long-wavelength ultraviolet A light (UVA, 320-400 nm) induces the formation of interstrand cross-links in DNA. Psoralen plus UVA (PUVA) is widely used in the treatment of psoriasis, a hyperproliferative disease of the skin.
F P, Gasparro, G, Chan, R L, Edelson
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ACS Infectious Diseases, 2016 Photopharmacological agents exhibit light-dependent biological activity and may have potential in the development of new antimicrobial agents/modalities. Amidohydrolase enzymes homologous to the well-known human histone deacetylases (HDACs) are present in bacteria, including resistant organisms responsible for a significant number of hospital-acquired ...
Weston, CE +6 more
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Building Bridges:the magic of light andthe logic of molecules [PDF]
The inaugural lecture of Prof. Wiktor Szymanski, newly appointed as chair of Medicinal Chemistry, Photopharmacology and Imaging, will focus on building bridges between disciplines, faculties and ideas.
Szymanski, Wiktor
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Study of the bactericidal effect of a light-transducing molecule on Escherichia coli [PDF]
, 2021 LAUREA MAGISTRALEIn questo lavoro ho studiato una molecola fotoattiva in grado di ripartirsi nella membrana lipidica dei batteri e di agire come un sistema antibatterico modulato dalla luce visibile.
Sora, Elia
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Azologization of serotonin 5-HT3 receptor antagonists
Beilstein Journal of Organic Chemistry, 2019 The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). The 5-
Karin Rustler +3 more
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Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands. [PDF]
PNAS NexusAcetylcholine and the cholinergic system are crucial to brain function, including functions such as consciousness and cognition. Dysregulation of this system is implicated in the pathophysiology of neurological conditions such as Alzheimer's disease. For
Sanchez-Sanchez JM +11 more
europepmc +3 more sources
Introduction to photoswitches and photopharmacology
Organic & Biomolecular ChemistryLight-control has become an essential element in biomedical research and chemical biology, since photons offer the possibility of precisely confining biological activity in space and time. Employing light-responsive molecules that undergo a structural change upon irradiation, researchers have been able to engineer pharmacophores whose bioactivity can ...
Cacciarini, Martina +3 more
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Use of styrylbenzothiazole photoswitches in drugs for spatiotemporal control over microtubule-dependent biology [PDF]
, 2021 Thousands of biological processes take place within a single cell, every second of its existence. These processes are meticulously orchestrated and highly regulated in order to guarantee proper functioning and homeostasis within the organism.
Gao, Li
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Introduction: Optogenetics and Photopharmacology [PDF]
Chemical Reviews, 2018 Ernst Bamberg +2 more
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Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY
Journal of Functional BiomaterialsNitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies.
Natalia A. Virts +4 more
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