Results 21 to 30 of about 1,927 (190)

Emerging Targets in Photopharmacology [PDF]

Angewandte Chemie International Edition, 2016
AbstractThe field of photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of resistance, while achieving unprecedented precision in treatment. By using small molecules, photopharmacology provides a viable alternative to optogenetics.
Michael M. Lerch, Mickel J. Hansen, Gooitzen M. van Dam, Wiktor Szymanski, Ben L. Feringa   +4 more
openaire   +3 more sources

Photoresponsive prodrug‐dye nanoassembly for in‐situ monitorable cancer therapy

Bioengineering & Translational Medicine, 2022
Photocleavable prodrugs enable controllable drug delivery to target sites modulated by light irradiation. However, the in vivo utility is usually hindered by their insolubility and inefficient delivery.
Kaiqi Long, Yifan Wang, Wen Lv, Yang Yang, Shuting Xu, Changyou Zhan, Weiping Wang   +6 more
doaj   +1 more source

A Solid-State Fluorescence Switch Based on Triphenylethene-Functionalized Dithienylethene With Aggregation-Induced Emission

Frontiers in Chemistry, 2021
The development of novel dithienylethene-based fluorescence switches in the aggregated state, and the solid state is highly desirable for potential application in the fields of optoelectronics and photopharmacology.
Haining Zhang, Xiaoxiao Hu, Huijuan Zhu, Limin Shen, Congmin Liu, Xiaoman Zhang, Xinyu Gao, Lingmei Li, Yan-Ping Zhu, Ziyong Li   +9 more
doaj   +1 more source

Synthesis and Study of Dibenzo[b, f]oxepine Combined with Fluoroazobenzenes—New Photoswitches for Application in Biological Systems

Molecules, 2022
Dibenzo[b, f]oxepine derivatives are an important scaffold in natural, medicinal chemistry, and these derivatives occur in several medicinally relevant plants.
Filip Borys, Piotr Tobiasz, Jakub Sobel, Hanna Krawczyk   +3 more
doaj   +1 more source

A Transient Phenolate Enables Relaxation of Z-Tetra-ortho-fluoroazobenzene to the Stable State in Seconds. [PDF]

Angew Chem Int Ed Engl
The rate of Z‐to‐E isomerization of a tetrafluoroazobenzene subunit in a spiropyran hybrid is controlled by the rate of merocyanine formation. Rate accelerations of 102–106 were observed for changes in solvent polarity, UV light irradiation and passage through silica.
Brittain W, Barrett S, Mouer L, Sauceda N.   +3 more
europepmc   +3 more sources

Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography

Nature Communications, 2023
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitude in
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss   +30 more
doaj   +1 more source

Optogenetics and photopharmacology in pain research and therapeutics

STEMedicine, 2020
Pain afflicts billions of people worldwide, who suffer especially from long-term chronic pain. This gruelling condition affects the nervous system at all levels: from the brain to the spinal cord, the Dorsal Root Ganglia (DRG) and the peripheral fibres ...
Federico Iseppon, Manuel Arcangeletti
doaj   +1 more source

Aryl azopyrroles as visible light photoswitchable TRPA1 ligands. [PDF]

Chem Sci
Access to high quality optochemogenetic tools will enable precise interrogation of the complex biology of diverse cell types, allowing temporally and spatially controlled manipulation of cell autonomous functions.
Dollhopf LC, Munos JA, Zheng KY, Tao RX, Haycock PR, Parsons PJ, Peterson RT, Lam PY, Fuchter MJ.   +8 more
europepmc   +3 more sources

Optical control of NMDA-receptors with a diffusible photoswitch [PDF]

, 2015
N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity, learning and memory, and are implicated in various neuronal disorders.
Di Gregorio, David, Franckevicius, Vilius, Hartrampf, Felix, Hollmann, M., Laprell, Laura, Rebola, Nelson, Repak, Emilienne, Sumser, Martin, Terhag, Jan, Trauner, Dirk   +9 more
core   +4 more sources

Allosteric optical control of a class B G-protein-coupled receptor [PDF]

, 2016
Allosteric regulation promises to open up new therapeutic avenues by increasing drug specificity at G‐protein‐coupled receptors (GPCRs). However, drug discovery efforts are at present hampered by an inability to precisely control the allosteric site ...
Broichhagen, Broichhagen, Broichhagen, Broichhagen, Campbell, Chen, Gefel, Gromada, Holz, Holz, Holz, Inzucchi, Nolan, Nolte, Parker, Pittolo, Thorens, Velema, Volgraf, Willard, Wootten   +20 more
core   +1 more source