Results 31 to 40 of about 1,927 (190)

Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue [PDF]

, 2021
Photopharmacology addresses the challenge of drug selectivity and side effects through creation of photoresponsive molecules activated with light with high spatiotemporal precision.
Arkhipova, Valentina, Feringa, B.L., Fu, Haigen, Guskov, Albert, Hoorens, Mark, Lameijer, Lucien, Marin, Egor, Poelarends, Gerrit, Slotboom, Dirk, Szymanski, Wiktor, Trinco, Gianluca   +10 more
core   +1 more source

GPCR photopharmacology

Molecular and Cellular Endocrinology, 2019
New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved ...
Maria Ricart-Ortega, Joan Font, Amadeu Llebaria   +2 more
openaire   +3 more sources

Azobenzene photocontrol of peptides and proteins [PDF]

, 2016
The last few years have witnessed significant advances in the use of light as a stimulus to control biomolecular interactions. Great efforts have been devoted to the development of genetically encoded optobiological and small photochromic switches. Newly
Allemann, Rudolf, Mart, Robert
core   +1 more source

Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes [PDF]

, 2017
Development of powerful fluorescence imaging probes and techniques sets the basis for the spatiotemporal tracking of cells at different physiological and pathological stages.
Feringa, Ben L., Fu, Youxin, Han, Hai-Hao, He, Xiao-Peng, Li, Jia, Tian, He, Zang, Yi, Zhang, Junji   +7 more
core   +2 more sources

Comparative EPR Study on the Scavenging Effect of Methotrexate with the Isomers of Its Photoswitchable Derivative

Pharmaceuticals, 2021
The scavenging effect of the antimetabolite dihydrofolate reductase inhibitor methotrexate (MTX) and the isomers of its photoswitchable derivate, cis- and trans-phototrexate (PHX), have been compared by ESR spectroscopy, with the application of a cyclic ...
Zsolt Preisz, Nóra Hartvig, Balázs Bognár, Tamás Kálai, Sándor Kunsági-Máté   +4 more
doaj   +1 more source

Photopharmacology of Quinoline and Benzimidazole Azobenzene-Based Photoswitchable β‑Hematin Inhibitors [PDF]

ACS Omega
Taryn M. Golding, Tristan K. Theunissen, Susan A. Bourne, Catharine Esterhuysen, Gregory S. Smith   +4 more
doaj   +2 more sources

Light-Based Molecular Tools to Precisely Monitor and Operate β-Adrenoceptors. [PDF]

Med Res Rev
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Maria Tindara I, Xavier GS, Amadeu L, Xavier R.   +3 more
europepmc   +2 more sources

On the promise of photopharmacology using photoswitches: a medicinal chemist's perspective. [PDF]

, 2020
Photopharmacology is a growing area of endeavor that employs photoswitchable ligands to allow for light-dependent pharmacological activity. By coupling light to therapeutic action, improved spatial and temporal selectivity can be achieved and ...
Fuchter, MJ
core   +1 more source

Photoactivatable prodrugs of antimelanoma agent Vemurafenib [PDF]

, 2015
In this study, we report on novel photoactivatable caged prodrugs of vemurafenib. This kinase inhibitor was the first approved drug for the personalized treatment of BRAF-mutated melanoma and showed impressive results in clinical studies.
Bollag G., Bollag G., Boris Pinchuk, Byrnes K. R., Chapman P. B., Christian Peifer, Collins I., Curley K., Dar A. C., Dario Alessi, Dissanayake K., Ellis-Davies G. C. R., Flaherty K. T., Jang S., Johannessen C. M., Kaplan J. H., Klán P., Lee J. T., Levitzki A., Li H., Matsumura Y., Mayer G., Morckel A. R., Morison W. L., Paul Davies, Pelliccioli A. P., Poulikakos P. I., Rabiller M., Rebecca Horbert, Shi H., Shi H., Sosman J. A., Swaika A., Søndergaard J. N., Veldhuyzen W. F., Velema W. A., Villanueva J., Wang Q., Wood J. S., Yang H.   +39 more
core   +3 more sources

From:E to Z and back again: Reversible photoisomerisation of an isolated charge-tagged azobenzene [PDF]

, 2018
Substituted azobenzenes serve as chromophores and actuators in a wide range of molecular photoswitches. Here, tandem ion mobility spectrometry coupled with laser excitation is used to investigate the photoisomerisation of selected E and Z isomers of the ...
Adamson, Adamson, Bandara, Beharry, Besler, Bisle, Branco, Bull, Bull, Bull, Bull, Campuzano, Chai, Dirksen, Dong, Dunning, Jr., Eduardo Carrascosa, Eiceman, Einaga, Ernst, Evan J. Bieske, Fehrentz, Fujino, James N. Bull, Mesleh, Meyer, Michael S. Scholz, Neese, Nägele, Poyer, Renner, Riplinger, Sanchez, Scholz, Schultz, Silvi, Stephan, Takei, Tan, Weston, Yano   +40 more
core   +2 more sources