Results 41 to 50 of about 1,927 (190)
Nature Communications, 2022 Wireless delivery of both light and pharmacological agents is important for optogenetic and other mechanistic experiments in the brain. Here the authors present a wireless real-time programmable optofluidic platform that enables optogenetics and ...
Yixin Wu +26 more
doaj +1 more source
In vivo photopharmacology with light-activated opioid drugs
Neuron, 2023 Traditional methods for site-specific drug delivery in the brain are slow, invasive, and difficult to interface with recordings of neural activity. Here, we demonstrate the feasibility and experimental advantages of in vivo photopharmacology using "caged" opioid drugs that are activated in the brain with light after systemic administration in an ...
Shannan P. McClain +17 more
openaire +4 more sources
Optical control of insulin secretion using an incretin switch [PDF]
, 2015 Incretin mimetics are set to become a mainstay of type 2 diabetes treatment. By acting on the pancreas and brain, they potentiate insulin secretion and induce weight loss to preserve normoglycemia.
Aemissegger +30 more
core +1 more source
Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors. [PDF]
, 2015 REarranged during Transfection (RET) is a transmembrane receptor tyrosine kinase required for normal development and maintenance of neurons of the central and peripheral nervous systems.
Andréasson, Joakim +4 more
core +1 more source
Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine
Pharmaceuticals, 2023 The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body.
Alexey Noev +5 more
doaj +1 more source
Light-Control over Casein Kinase 1δ Activity with Photopharmacology:A Clear Case for Arylazopyrazole-Based Inhibitors [PDF]
, 2022 Protein kinases are responsible for healthy cellular processes and signalling pathways, and their dysfunction is the basis of many pathologies. There are numerous small molecule inhibitors of protein kinases that systemically regulate dysfunctional ...
Feringa, Ben L. +6 more
core +1 more source
Isomerisation of an intramolecular hydrogen-bonded photoswitch:Protonated azobis(2-imidazole) [PDF]
, 2017 Photoisomerisation of protonated azobis(2-imidazole), an intramolecular hydrogen-bonded azoheteroarene photoswitch molecule, is investigated in the gas phase using tandem ion mobility mass spectrometry.
Bieske, Evan J. +3 more
core +2 more sources
Three‐Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo [PDF]
, 2023 To interrogate neural circuits and crack their codes, in vivo brain activity imaging must be combined with spatiotemporally precise stimulation in three dimensions using genetic or pharmacological specificity. This challenge requires deep penetration and
Agnetta, Luca +13 more
core +1 more source
Substituted nitrogen-bridged diazocines
Beilstein Journal of Organic Chemistry, 2021 Novel nitrogen-bridged diazocines (triazocines) were synthesized that carry a formyl or an acetyl group at the CH2NR-bridge and bromo- or iodo-substituents at the distant phenyl ring.
Pascal Lentes +3 more
doaj +1 more source
Photopharmacological Control of Cyclic Antimicrobial Peptides
ChemBioChem, 2018 AbstractGramicidin S is a naturally occurring antimicrobial cyclic peptide. Herein, we present a series of cyclic peptides based on gramicidin S that contain an azobenzene photoswitch to reversibly control secondary structure and, hence, antimicrobial activity.
Yuan Qi Yeoh +4 more
openaire +5 more sources