Results 51 to 60 of about 1,927 (190)
Sensitized Disequilibration of Water‐Soluble Azopolymers
Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.Disequilibration by sensitization under confinement (DESC) is a promising strategy for efficient visible‐light‐induced azobenzene E→Z isomerization. In this article, we explored key factors for adapting DESC to azopolymers, eventually achieving efficiencies up to 85% compared to direct excitation and laying the foundation for more complex systems ...
Henning Jörn Meteling +4 more
wiley +2 more sources
Recent Approaches to the Identification of Novel Microtubule-Targeting Agents
Frontiers in Molecular Biosciences, 2022 Microtubules are key components of the eukaryotic cytoskeleton with essential roles in cell division, intercellular transport, cell morphology, motility, and signal transduction.
Susanna Eli +3 more
doaj +1 more source
Optochemical Control of Immune Checkpoint Blockade via Light‐Triggered PD‐L1 Dimerization
Advanced NanoBiomed Research, 2022 The blockade of PD‐1/PD‐L1, which serves to “release the brake” of tumor immunity, represents a promising approach for treating various malignancies. However, the systemic immune‐related side effects significantly undermine its therapeutic efficacy.
Yuwei Liu +4 more
doaj +1 more source
Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology [PDF]
, 2018 International ...
Goudet, Cyril +2 more
core +3 more sources
Frontiers in Immunology, 2020 Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca2+ handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses.
Bernadett Bacsa +7 more
doaj +1 more source
In vivophotopharmacology enabled by multifunctional fibers [PDF]
ACS Chemical Neuroscience, 2020 ABSTRACTTo reversibly manipulate neural circuits with increased spatial and temporal control, photoswitchable ligands can add an optical switch to a target receptor or signaling cascade. This approach, termed photopharmacology, has been enabling to molecular neuroscience, however, its application to behavioral experiments has been impeded by a lack of ...
James A. Frank +9 more
openaire +2 more sources
Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca 2+ fluxes [PDF]
, 2023 We previously developed, synthesized and tested light-activated sulfonylureas for optical control of KATP channels and pancreatic beta cell activity in vitro and in vivo.
Ast, Julia +6 more
core +2 more sources
First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent
Cells, 2023 Compounds that disrupt microtubule dynamics, such as colchicine, paclitaxel, or Vinca alkaloids, have been broadly used in biological studies and have found application in clinical anticancer medications.
Filip Borys +4 more
doaj +1 more source
Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches
Responsive MaterialsIn the era of precision medicine, photopharmacology that employs molecular photoswitches offers unique opportunities to control the action of bioactive molecules with high spatiotemporal resolution, while reducing drug side effects, systemic toxicity and
Yongliang Feng +7 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2020 This study evaluates the embryotoxicity of dithienylethene-modified peptides upon photoswitching, using 19 analogues based on the β-hairpin scaffold of the natural membranolytic peptide gramicidin S.
Sergii Afonin +7 more
doaj +1 more source