Results 61 to 70 of about 1,927 (190)

Chronophotopharmacology:towards chronotherapy with high spatio-temporal precision [PDF]

, 2020
Even the most sophisticated watches are imperfect timekeepers and their ability to measure time is affected throughout their lifespan. This problem can be solved by mechanical adjustment or a battery replacement.
Kolarski, Dusan
core   +1 more source

Novel 3D‐Printed Biophotonic Scaffold Displaying Luminescence under Near‐Infrared Light for Photopharmacological Activation and Biological Signaling Compound Release

Advanced Healthcare Materials, EarlyView.
Despite significant efforts in developing novel biomaterials to regenerate tissue, only a few of them have successfully reached clinical use. It has become clear that the next generation of biomaterials must be multifunctional. Smart biomaterials can respond to environmental or external stimuli, interact in a spatial‐temporal manner, and trigger ...
Sonya Ghanavati, Ekin Opar, Virginia Alessandra Gobbo, Carlo Matera, Fabio Riefolo, Rossella Castagna, Julien Colombelli, Andrew Draganski, Joshua Baggott, Mika Lastusaari, Pau Gorostiza, Laeticia Petit, Jonathan Massera   +12 more
wiley   +1 more source

Photopharmacological Tools for Mitotic Cell Division

YAKUGAKU ZASSHI, 2022
Genetic information is replicated and transmitted from a parent cell to two identical daughter cells through mitotic cell division. To accomplish this dynamic process with high accuracy and precision, various motor proteins work in a concerted manner.
openaire   +2 more sources

Reversible photocontrol of dopaminergic transmission in wild-type animals [PDF]

, 2022
Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved in the modulation of fundamental physiological functions and dysregulation of dopaminergic transmission is associated with major ...
Calvé, Pablo, Casadó Anguera, Verònica, Casadó, Vicent, Conde-Berriozabal, Sara, Costazza, Davide, Delgado-Sallent, Cristina, Gener, Thomas, Gomila, Alexandre M.J., Gorostiza Langa, Pablo Ignacio, Hernando, Jordi, Masana Nadal, Mercè, Matera, Carlo, Moreno Guillén, Estefanía, Nebot, Pau, Puig, M.Victoria, Sortino, Rosalba   +15 more
core   +3 more sources

Development of 4D printing and its performance testing methods

Responsive Materials, EarlyView.
This paper reviews the molding methods of 4D printing and its applications in various fields, with emphasis on 4D printing performance testing methods. Abstract 4D printing is a cutting‐edge additive manufacturing technology that introduces the time dimension, allowing printed objects to have dynamic, changeable properties, functions or shapes ...
Guiwei Li, Chaoyue Huang, Yucheng Luo, Jialu Xu, Lei Zhang, Fei Gao, Ke Li, Wenzheng Wu, Luquan Ren   +8 more
wiley   +1 more source

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

eLife, 2018
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors.
Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jérémie Naudé, Thibaut d'Izarny-Gargas, Stéphanie Pons, Uwe Maskos, Dirk Trauner, Richard H Kramer, Philippe Faure, Alexandre Mourot   +12 more
doaj   +1 more source

Hypothesis-Driven, Structure-Based Design in Photopharmacology:The Case of eDHFR Inhibitors [PDF]

, 2022
[Image: see text] Photopharmacology uses light to regulate the biological activity of drugs. This precise control is obtained through the incorporation of molecular photoswitches into bioactive molecules.
de Vries, Jisk, Feringa, Ben L, Galenkamp, Nicole S, Kobauri, Piermichele, Kolarski, Dušan, Maglia, Giovanni, Schulte, Albert M, Simeth, Nadja A, Szymanski, Wiktor, Thallmair, Sebastian   +9 more
core   +1 more source

Reducing the Formation of Toxic Byproducts During the Photochemical Release of Epinephrine

Journal of Xenobiotics
Engineered light-sensitive molecules offer a sophisticated toolkit for the manipulation of biological systems with both spatial and temporal precision.
Mikhail A. Panfilov, Ezhena S. Starodubtseva, Tatyana Yu. Karogodina, Alexey Yu. Vorob’ev, Alexander E. Moskalensky   +4 more
doaj   +1 more source

A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light

Beilstein Journal of Organic Chemistry, 2019
We report a detailed structure–activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3.
Xavier Gómez-Santacana, Sabrina M. de Munnik, Tamara A. M. Mocking, Niels J. Hauwert, Shanliang Sun, Prashanna Vijayachandran, Iwan J. P. de Esch, Henry F. Vischer, Maikel Wijtmans, Rob Leurs   +9 more
doaj   +1 more source