Results 71 to 80 of about 1,927 (190)
Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
Advanced Science, 2021 The ability to control neural activity is essential for research not only in basic neuroscience, as spatiotemporal control of activity is a fundamental experimental tool, but also in clinical neurology for therapeutic brain interventions.
Almudena Barbero‐Castillo +9 more
doaj +1 more source
Optical Control of Glycerolipids and Sphingolipids
CHIMIA, 2021 Glycerolipids, Sphingolipids, and Sterols are the three major classes of membrane lipids. Both glycerolipids and sphingolipids are comprised of combinations of polar headgroups and fatty acid tails. The fatty acid tail can be chemically modified with an
Johannes Morstein, Dirk Trauner
doaj +1 more source
Photoswitchable basicity through the use of azoheteroarenes
, 2016 We report an azoheteroarene photoswitchable base, where proton stabilisation in Z isomer is facilitated by neighbouring imidazole rings. A 1.3 unit difference in pKa is observed between the E and Z isomers, which leads to the ability to reversibly ...
Fuchter, MJ, Richardson, RD, Weston, CE
core +1 more source
Remote control of movement disorders using a photoactive adenosine A(2A) receptor antagonist [PDF]
, 2020 G protein-coupled adenosine receptors are promising therapeutic targets for a wide range of neuropathological conditions, including Parkinson's disease (PD).
Cabre, Gisela +8 more
core +1 more source
Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock [PDF]
, 2021 CRY1 and CRY2 proteins are highly conserved components of the circadian clock that controls daily physiological rhythms. Disruption of CRY functions are related to many diseases, including circadian sleep phase disorder.
Amaike, Kazuma +14 more
core +1 more source
STAR Protocols, 2021 Summary: Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly gaining widespread recognition for investigations of transient receptor potential canonical (TRPC) channels.
Trese Leinders-Zufall +6 more
doaj +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 3, 16 January 2026.We present a photoswitchable peptide conjugate which exhibits isomerism‐dependent self‐assembly: the planar trans‐isomer assembles into well‐ordered nanofibers while the non‐planar cis‐isomer yields disordered aggregates. Our study offers a direct visualization on the effects of structure formation inside living cells.
Julian Link +6 more
wiley +1 more source
Bioinspired Light‐Driven Organic Rotary Molecular Systems
ChemistryEurope, Volume 4, Issue 1, January 2026.This review explores the evolution of bioinspired light‐driven rotary molecular systems (RMSs), highlighting the integration of natural chromophore‐based fragments to enhance quantum efficiency, photostability, and biocompatibility. Key strategies to optimize photochemical performance and broaden functional applications are discussed, providing a ...
Lidia Hortigüela, Sara P. Morcillo
wiley +1 more source
Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides
eLife, 2019 Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress in understanding how ceramides execute their biological roles is hampered by a lack of methods to ...
Matthijs Kol +9 more
doaj +1 more source