Results 21 to 30 of about 54,838 (149)

Discordant Responses to MAPK Pathway Stimulation Include Axonal Growths in Adult Drosophila Photoreceptors

Frontiers in Molecular Neuroscience, 2018
Wallenda (WND) is the Drosophila member of a conserved family of dual leucine-zipper kinases (DLK) active in both neuronal regeneration and degeneration.
Kirk L. Mecklenburg, Forrest P. Weghorst, Stephanie A. Freed, Joseph E. O’Tousa   +3 more
doaj   +1 more source

Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration

Molecular Therapy: Methods & Clinical Development, 2021
Photoreceptor loss is the principal cause of blindness in retinal degenerative diseases (RDDs). Whereas some therapies exist for early stages of RDDs, no effective treatment is currently available for later stages, and once photoreceptors are lost, the ...
Anna Salas, Anna Duarri, Laura Fontrodona, Diana Mora Ramírez, Anna Badia, Helena Isla-Magrané, Barbara Ferreira-de-Souza, Miguel Ángel Zapata, Ángel Raya, Anna Veiga, José García-Arumí   +10 more
doaj   +1 more source

Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia

Cells, 2021
Diabetic retinopathy is a frequent complication of longstanding diabetes, which comprises a complex interplay of microvascular abnormalities and neurodegeneration.
Nicole Schmitner, Christina Recheis, Jakob Thönig, Robin A. Kimmel   +3 more
doaj   +1 more source

Limitations and Promise of Retinal Tissue From Human Pluripotent Stem Cells for Developing Therapies of Blindness

Frontiers in Cellular Neuroscience, 2020
The self-formation of retinal tissue from pluripotent stem cells generated a tremendous promise for developing new therapies of retinal degenerative diseases, which previously seemed unattainable.
Ratnesh K. Singh, Igor O. Nasonkin
doaj   +1 more source

Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival

Cells, 2021
Lysosomes are membrane-bound cell organelles that respond to nutrient changes and are implicated in cell homeostasis and clearance mechanisms, allowing effective adaptation to specific cellular needs.
Manuela Santo, Ivan Conte
doaj   +1 more source

Pore Forming Properties of Cecropin-Melittin Hybrid Peptide in a Natural Membrane

Molecules, 2009
The pore forming properties of synthetic cecropin-melittin hybrid peptide (Acetyl-KWKLFKKIGAVLKVL-CONH2; CM15) were investigated by using photoreceptor rod outer segments (OS) isolated from frog retinae obtained by using the whole-cell configuration of ...
Giorgio Rispoli, Marco Aquila, Alberto Milani, Mascia Benedusi   +3 more
doaj   +1 more source

Functionally Assessing the Age-Related Decline in the Detection Rate of Photons by Cone Photoreceptors

Frontiers in Aging Neuroscience, 2021
Age-related decline in visual perception is usually attributed to optical factors of the eye and neural factors. However, the detection of light by cones converting light into neural signals is a crucial intermediate processing step of vision ...
Asma Braham chaouche, Maryam Rezaei, Daphné Silvestre, Angelo Arleo, Rémy Allard   +4 more
doaj   +1 more source

Synaptic Remodeling in the Cone Pathway After Early Postnatal Horizontal Cell Ablation

Frontiers in Cellular Neuroscience, 2021
The first synapse of the visual pathway is formed by photoreceptors, horizontal cells and bipolar cells. While ON bipolar cells invaginate into the photoreceptor terminal and form synaptic triads together with invaginating horizontal cell processes, OFF ...
Lena Nemitz, Karin Dedek, Karin Dedek, Ulrike Janssen-Bienhold, Ulrike Janssen-Bienhold   +4 more
doaj   +1 more source

Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina

Stem Cell Research & Therapy
Background The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as potential vehicles for delivering therapeutic cargo.
Margaret T. Ho, Kotoe Kawai, Dhana Abdo, Lacrimioara Comanita, Arturo Ortin-Martinez, Yui Ueno, Emily Tsao, Azam Rastgar-Moghadam, Chang Xue, Hong Cui, Valerie A. Wallace, Molly S. Shoichet   +11 more
doaj   +1 more source

A Defective Crosstalk Between Neurons and Müller Glial Cells in the rd1 Retina Impairs the Regenerative Potential of Glial Stem Cells

Frontiers in Cellular Neuroscience, 2019
Müller glial cells (MGC) are stem cells in the retina. Although their regenerative capacity is very low in mammals, the use of MGC as stem cells to regenerate photoreceptors (PHRs) during retina degenerations, such as in retinitis pigmentosa, is being ...
Yanel A. Volonté, Harmonie Vallese-Maurizi, Marcos J. Dibo, Victoria B. Ayala-Peña, Andrés Garelli, Samanta R. Zanetti, Axel Turpaud, Cheryl Mae Craft, Cheryl Mae Craft, Nora P. Rotstein, Luis E. Politi, Olga L. German   +11 more
doaj   +1 more source