Results 131 to 140 of about 3,532 (155)

Intrapleural CTB‐saporin selectively kills phrenic motor neurons: a motor neuron disease model

The FASEB Journal, 2013
Amyotrophic lateral sclerosis (ALS) is a devastating disease leading to progressive motor neuron degeneration and ultimately, ventilatory failure. In a rodent model of ALS (SOD1 G93A rats), ventilatory capacity is preserved despite >;50% loss of phrenic and intercostal motor neurons (
Nicole Louise Nichols, Stephane Vinit, Gordon S Mitchell   +2 more
openaire   +1 more source

Phrenic motor neuron activation using temporal interference stimulation

The FASEB Journal, 2020
Based on deep brain stimulation data, we are using a method called temporal interference (T‐I) stimulation to activate phrenic motor neurons in adult rats. The premise is to target the deep ventral motor pools of the spinal cord with two high frequency but low amplitude electrical ...
Michael D. Sunshine, Antonino M. Cassarà, Esra M. Neufeld, Nir Grossman, Kevin J. Otto, Edward S. Boyden, David D. Fuller   +6 more
openaire   +1 more source

Postnatal Inhibition of TrkB Kinase Reduces the Number of Phrenic Motor Neurons

Physiology, 2023
During embryonic development, the number of phrenic motor neurons (PhMNs) declines precipitously during the final trimester and continues into the early postnatal period. When BDNF/TrkB signaling is absent in utero, animals do not survive after birth, most likely due to excessive loss of vital motor neurons (e.g., PhMNs).
Joline Brandenburg, Matthew Fogarty, Wen-Zhi Zhan, Gary Sieck   +3 more
openaire   +1 more source

Age‐Related Loss of Phrenic Motor Neurons: Reduced Myogenic Influence?

The FASEB Journal, 2020
There is an age‐associated loss of phrenic motor neurons (PhMNs) and withdrawal of pre‐synaptic terminals at neuromuscular junctions (NMJs) in 24‐month old Fischer 344 (F344) rats. Previously, we showed that age‐related PhMN loss is concomitant with neuromuscular transmission failure and diaphragm muscle (DIAm)
Ann M. Wilfred, Matthew J. Fogarty, Carlos B. Mantilla, Gary C. Sieck   +3 more
openaire   +1 more source

Size‐Dependence of Mitochondrial Density & Morphology in Phrenic Motor Neurons

The FASEB Journal, 2020
Neuromotor control of diaphragm muscle is dependent on the orderly recruitment of phrenic motor neurons (PhMNs) in a size‐dependent manner. Type S and FR motor units comprise smaller, more easily recruited PhMNs that innervate fatigue resistant, lower force‐producing type I and type IIa muscle fibers. Type FInt
Matthew J. Fogarty, Sabhya Rana, Carlos B. Mantilla, Gary C. Sieck   +3 more
openaire   +1 more source

Age-Related Loss of Phrenic Motor Neurons in Rats

Physiology
The diaphragm muscle (DIAm) is the major inspiratory muscle. Neural control of DIAm activation involves recruitment of phrenic motor neurons. Activation of the DIAm during breathing involes recruitment of fatigue resistant motor units comprising smaller PhMNs and type I and IIa muscle fibers. More force, but infrequent non-ventilatory behaviors of the
Aliyah Alabdulqadar, Matthew Fogarty, Debanjali Dasgupta, Carlos B. Mantilla, Gary C. Sieck   +4 more
openaire   +1 more source

Histological Analysis of Phrenic Motor Neurons Pompe Disease

Physiology
Pompe disease is a neuromuscular disorder resulting from mutations in the gene encoding acid α-glucosidase (GAA), an enzyme responsible for lysosomal glycogen degradation. Intravenous enzyme replacement therapy is the current standard of care but does not target the central nervous system (CNS).
Cabral Katelyn, Sabhya Rana, Megan Pope, Manuela Corti, Ramon Sun, Matthew Gentry, Barry Byrne, David Fuller   +7 more
openaire   +1 more source

Phrenic Motor Neuron Expression of Receptors Known to Elicit Phrenic Motor Facilitation After Daily Acute Intermittent Hypoxia Preconditioning

The FASEB Journal, 2017
Spinal serotonin receptor activation elicits a form of respiratory motor plasticity known as phrenic motor facilitation (pMF). One specific form of pMF is phrenic long‐term facilitation (pLTF) following acute intermittent hypoxia (AIH) exposure.
Latoya Lynn Allen, Irawan Satriotomo, Alec K. Simon, Gordon S. Mitchell   +3 more
openaire   +1 more source

Phrenic Motor Neuron Fractalkine Signaling to Nearby Microglia Regulates Phrenic Long-Term Facilitation

Physiology
Although microglia are traditionally regarded as innate CNS immune cells, recent studies demonstrate that microglia also play key roles in normal CNS functions. For example, microglia engage in bidirectional communication with other cell types ( e.g., neurons) to regulate diverse processes including neuronal excitability, architecture and synaptic ...
Alexandria Marciante, Gordon Mitchell
openaire   +1 more source

[Dendrite projection zones in the phrenic motor neurons of the cat].

Biulleten' eksperimental'noi biologii i meditsiny, 1986
The fields of dendrite arborization (projections) were examined in phrenic nuclei of adult cats. Six types (five radial and one longitudinal) of phrenic motoneuron dendrites have been determined. The radial dendrites can project to lamina VIII or VII, to lateral and ventrolateral locomotor nuclei and to all funiculi of the white matter surrounding the ...
openaire   +1 more source