Results 141 to 150 of about 2,517,871 (188)
Utilising phytanic acid diastereomers for the characterisation of archaeological lipid residues in pottery samples [PDF]
Tetrahedron Letters, 2016 Phytanic acid diastereomers, 3S,7R,11R,15-phytanic acid (SRR) and 3R,7R,11R,15-phytanic acid (RRR), were determined by GC-MS in extracts of archaeological ceramic.
Andre Carlo Colonese +2 more
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Phytanic acid: production from phytol, its breakdown and role in human disease
Cellular and Molecular Life Sciences, 2006 Phytanic acid is a branched-chain fatty acid that accumulates in a variety of metabolic disorders. High levels of phytanic acid found in patients can exceed the millimolar range and lead to severe symptoms.
Ronald Wanders, Daan M Van Den Brink
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Intraorganellar localization of CoASH-independent phytanic acid oxidation in human liver peroxisomes [PDF]
FEBS Letters, 1993 In human tissues phytanic acid is α-oxidized to pristanic acid in peroxisomes. Studies of the intraorganellar site of α-oxidation of [1-14C]phytanic acid to pristanic acid in peroxisomes isolated from human liver demonstrate that phytanoyl-CoA ligase is ...
Kalipada Pahan, Inderjit Singh
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Human metabolism of phytanic acid and pristanic acid
Progress in Lipid Research, 2001Phytanic acid is a methyl-branched fatty acid present in the human diet. Due to its structure, degradation by beta-oxidation is impossible. Instead, phytanic acid is oxidized by alpha-oxidation, yielding pristanic acid. Despite many efforts to elucidate the alpha-oxidation pathway, it remained unknown for more than 30 years.
N M, Verhoeven, C, Jakobs
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Neurological disorders and phytanic acid metabolism
Acta Neurologica Scandinavica, 1988Fifty patients with neurological symptoms and signs resembling those of Refsum's disease were analyzed for phytanic acid in serum. In addition, the phytanic acid oxidase capacity in skin fibroblasts was determined. The patients suffered from retinitis pigmentosa, cerebellar ataxia and/or chronic polyneuropathy of unknown cause.
O H, Skjeldal +2 more
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Clinica Chimica Acta, 1987 Plasma samples from several Zellweger patients were found to contain elevated phytanic acid levels. It was subsequently found that the level of phytanic acid in plasma from Zellweger patients depends upon the age of the patients at the time of sampling ...
P G Barth, R B H Schutgens, P G Barth
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METABOLISM OF PHYTANIC ACID IN REFSUM'S DISEASE
The Lancet, 1982Abstract Because patients with Refsum's disease lack an α-hydroxylase they are unable to metabolise phytanic acid, which is present in most foods. However, a study of urinary metabolites in 4 patients with Refsum's disease demonstrated that ω-oxidation can replace the normal oxidation process to some extent.
J D, Billimoria +3 more
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Transport of Phytanic Acid on Lipoproteins in Refsum's Disease
Clinical Science, 1998AbstractPatients with Refsum disease accumulate significant quantities of phytanic acid in adipose and neural tissue. The accumulation can be reversed by following a diet low in phytanic acid, yet the mechanism of transport of this fatty acid is obscure.
A S, Wierzbicki +5 more
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The stereochemistry of phytanic acid in Refsum's Syndrome
Lipids, 1970AbstractPhytanic acid has been isolated from the total lipids of the liver of a human suffering from the disease, Refsum's Syndrome (Heredopathia atactica polyneuritiformis). Optical rotation measurements were made on the acid, and on the ketone 6,10,14‐trimethylpentadecan‐2‐one which resulted from the oxidative degradation of the acid and the ...
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Phytanic Acid, Amacr and Prostate Cancer Risk
Future Oncology, 2006The growing body of knowledge in cancer prevention demonstrates that for many cancers, risk must be defined in terms of both environmental and genetic factors. In prostate cancer, there is increasing evidence linking risk with polymorphisms in the alpha-methylacyl-CoA racemase (AMACR) gene and branched-chain fatty acids derived from specific sources of
Todd, Thornburg +5 more
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