Results 41 to 50 of about 5,394 (197)

Thematic Review Series: Sphingolipids. New insights into sphingolipid metabolism and function in budding yeast*

Journal of Lipid Research, 2008
Our understanding of sphingolipid metabolism and functions in the baker's yeast Saccharomyces cerevisiae has progressed substantially in the past 2 years.
Robert C. Dickson
doaj   +1 more source

Biosynthesis of long chain base in sphingolipids in animals, plants and fungi

Future Science OA, 2020
Long chain base (LCB) is a unique building block found in sphingolipids. The initial step of LCB biosynthesis stems from serine:palmitoyl-CoA transferase enzyme, producing 3-ketodihydrosphingosine with multiple regulatory proteins including small subunit
Ryuichi Mashima, Torayuki Okuyama, Mari Ohira   +2 more
doaj   +1 more source

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. [PDF]

, 2018
Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins.
Corrales, Dania Virginia, Edinger, Aimee L, Finicle, Brendan T, Joo, Yoosun, Liu, Gang, McCracken, Alison N, Mendoza, Victor D, Nguyen, Jannett, Ou, Kevin, Ramirez, Manuel U, Roy, Saurabh Ghosh, Selwan, Elizabeth M, Yu, Jingwen   +12 more
core   +1 more source

Synthesis of Amino Core Compounds of Galactosyl Phytosyl Ceramide Analogs for Developing iNKT-Cell Inducers

Molecules, 2012
1-Aminophytosphingosine and 6-aminogalactosyl phytosphingosine were prepared in 61% and 40% yield libraries with 44 carboxylic acids showed that a 4-butylbenzoic acid-derived product exe, respectively. Glycosylation using benzoyl-protected lipid resulted
Chung-Shan Yu, Ho-Lein Huang, Kuo-Yen Liao, Kun-I Lin, Kee-Ching Jeng, Yi-Hsian Lin, Kai-Shiang Chang, Wen-Chin Su, Yin-Cheng Huang, Li-Wu Chiang   +9 more
doaj   +1 more source

Structural diversity and biological significance of glycosphingolipids in pathogenic and opportunistic fungi [PDF]

, 2014
Glycosphingolipids (GSLs) are ubiquitous membrane components and have key roles in biological systems, acting as second messengers or modulators of signal transduction by affecting several events, ranging from cell adhesion, cell growth, cell motility ...
Anita Hilda Straus, Felipe Araujo Souza Ferreira, Helio K Takahashi, Luciana Lopes Guimaraes, Luciana Lopes Guimaraes, Marcos Sergio Toledo   +5 more
core   +2 more sources

An in silico approach for modelling T-helper polarizing iNKT cell agonists [PDF]

, 2014
Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involvement
ASPESLAGH, SANDRINE, Boucart, Maxime, De Spiegeleer, Anton, Elewaut, Dirk, Stalmans, Sofie, Van Calenbergh, Serge, Van Den Noortgate, Nele, Vandekerckhove, Matthias, Venken, Koen, Wynendaele, Evelien   +9 more
core   +3 more sources

Chemical synthesis of d-ribo-phytosphingosine-1-phosphate, a potential modulator of cellular processes

Journal of Lipid Research, 1999
d-erythro-Sphingosine-1-phosphate (2), an intermediate in sphingosine metabolism, shows a diversity of biological activities. Comparable roles might be anticipated for d-ribo-phytosphingosine-1-phosphate (1).
Shengrong Li, William K. Wilson, George J. Schroepfer, Jr.   +2 more
doaj   +1 more source

Multi-omics association analysis reveals interactions between the oropharyngeal microbiome and the metabolome in pediatric patients with influenza A virus pneumonia

Frontiers in Cellular and Infection Microbiology, 2022
Children are at high risk for influenza A virus (IAV) infections, which can develop into severe illnesses. However, little is known about interactions between the microbiome and respiratory tract metabolites and their impact on the development of IAV ...
Qian Hu, Baiming Liu, Yanqun Fan, Yuejie Zheng, Feiqiu Wen, Uet Yu, Wenjian Wang   +6 more
doaj   +1 more source

Fungal growth inhibitory properties of new phytosphingolipid analogues [PDF]

, 2007
7 pages, 5 figures.-- PMID: 18005346 [PubMed][Aims] To study the growth inhibitory properties of a series of phytosphingosine (PHS) and phytoceramide (PHC) analogues.[Methods and Results] A panel of two yeast (Candida albicans and Saccharomyces ...
Casas Brugulat, Josefina, Delgado, Antonio, Llebaria, Amadeu, Manresa, Ángeles, Mormeneo, David   +4 more
core   +1 more source

Identification and initial characterizations of free, glycosylated, and phosphorylated ceramides of Paramecium

Journal of Lipid Research, 1997
Paremecium tetraurelia contains high concentrations of six ethanolamine sphingolipids in the cell surface membrane surrounding somatic cilia.
E S Kaneshiro, K Jayasimhulu, D Sul, J A Erwin   +3 more
doaj   +1 more source