Results 81 to 90 of about 912,472 (266)

Robust CRISPR-Cas9 Genetic Editing of Primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma Cells

HemaSphere, 2023
Judith Mateos-Jaimez, Maurizio Mangolini, Anna Vidal, Marta Kulis, Dolors Colomer, Elias Campo, Ingo Ringshausen, Jose I. Martin-Subero, Alba Maiques-Diaz   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

P631: A PCR-BASED ASSAY FOR IGLV3-21R110 SCREENING CONFIRMS ITS PROGNOSTIC VALUE IN AN INDEPENDENT COHORT OF 613 PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA.

HemaSphere, 2022
C. Syrykh, N. Russiñol, T. Baumann, M. Kulis, M. Alcoceba, M. González, E. Colado, Á. R. Payer, M. Aymerich, M. J. Terol, S. Ruiz-Gaspà, A. López-Guillermo, J. I. Martín-Subero, D. Colomer, J. Delgado, E. Campo, F. Nadeu   +16 more
doaj   +1 more source

Свойство $K(\pi,1)$ для неособых отмеченных кривых над конечными полями

Известия Российской академии наук. Серия математическая, 2015
В случае неособых отмеченных кривых $(X,T)$ над конечными полями характеристики $p$ изучается свойство $K(\pi,1)$ для простого $p$. Доказано, что $(X,T)$ обладает свойством $K(\pi,1),$ если $X$ - аффинная кривая. Если $X$ - собственная кривая, приведены примеры, показывающие, что свойство может быть как выполнено, так и не выполнено.
Philippe Lebacque, Alexander Schmidt
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

P1260: UNRAVELING THE GENETICS OF TRANSFORMED SPLENIC MARGINAL ZONE LYMPHOMA

HemaSphere, 2022
M. Grau, C. López, A. Navarro, G. Clot, F. Nadeu, G. Bastidas, M. Alcoceba, M. J. Baptista, M. Blanes, F. Climent, D. Colomer, D. Costa, E. Domingo-Domènech, P. Forcada, A. Enjuanes, L. Escoda, G. Frigola, E. Giné, M. Lopez-Guerra, A. Rivas-Delgado, L. Vicente-Folch, A. Wotherspoon, E. Campo, A. López-Guillermo, E. Matutes, S. Beà   +25 more
doaj   +1 more source

Estimates of PI*S and PI*Z Alpha-1 antitrypsin deficiency alleles prevalence in the Caribbean and North, Central and South America

Monaldi Archives for Chest Disease, 2016
Background. AAT deficiency is not a rare disease, but one of the most common congenital disorders increasing susceptibility of individuals with this deficiency to both lung and liver disease as well as other several adverse health effects.
F.J. de Serres, I. Blanco, E. Fernández-Bustillo   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

PI S and PI Z Alpha-1 antitrypsin deficiency worldwide. A review of existing genetic epidemiological data

Monaldi Archives for Chest Disease, 2016
Background. AAT deficiency is not a rare disease, but one of the most common congenital disorders increasing susceptibility of deficiency individuals to both lung and liver disease as well as other several adverse health effects.
F.J. de Serres, I. Blanco, E. Fernández-Bustillo   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source