Results 181 to 190 of about 59,033 (267)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Zinc peroxide-copper bimetallic nanozyme with self-activated ROS and cuproptosis for superficial antifungal therapy. [PDF]

J Nanobiotechnology
Chen F, Ye Y, Yao Y, He J, Yu X, Zhang R, Ailifeire H, Luo C, Yao K, Tang X, Shentu X.   +10 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Alpha-Pinene and Tannic Acid Inhibit Trichomonas vaginalis Protozoan Cells by Inducing Apoptosis

Iranian Journal of Parasitology
Background: Trichomoniasis is one of the most common sexually transmitted infections worldwide. The growing concern of drug resistance of this infection has cautioned the need for new drug development.
Masoumeh Moradi, Dara Dastan, Mohammad Fallah, Manizhe Kashi Nahanji, Mohammad Matini   +4 more
doaj  

TPTE, a testis-specific PTEN family member, drives spermatogenesis via PI(4,5)P₂ synthesis. [PDF]

Cell Death Dis
Chen X, Wang T, Wu H, Zhang X, Chen H, Zhang L, Zhu Y, Zhang X, Wang B, Guo Y, Situ C, Zheng Y, Li Y, Guo X, Zhu H.   +14 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Typhoon-related Leptospirosis and Melioidosis, Taiwan, 2009

Emerging Infectious Diseases, 2011
Hsun-Pi Su, Ta-Chien Chan, Chao-Chin Chang   +2 more
doaj   +1 more source

Factors Associated with Pressure Injury Occurrence in Older Trauma Patients. [PDF]

Healthcare (Basel)
Kim M, Choi S.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Lack of myotubularin phosphatase activity is the main cause of X-linked myotubular myopathy. [PDF]

JCI Insight
Moschovaki-Filippidou F, Kretz C, Reiss D, Chicanne G, Payrastre B, Laporte J.   +5 more
europepmc   +1 more source