Results 101 to 110 of about 261,386 (249)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
European Physical Journal C: Particles and Fields, 2017 The decay modes $$\bar{B}_s \rightarrow \pi ^0(\rho ^0 )\,\eta ^{(')} $$ B ¯ s → π 0 ( ρ 0 ) η ( ′ ) are dominated by electroweak penguins that are small in the standard model.
Gaber Faisel
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
On the intersection of weighted Hardy spaces
Karpatsʹkì Matematičnì Publìkacìï, 2016 Let $H^p_\sigma( \mathbb{C}_+),$ $1\leq p 0 \}$ and such that $$\|f\|:=\sup\limits_{\varphi\in (-\frac{\pi}{2};\frac{\pi}{2})}\left\{\int\limits_0^{+\infty} |f(re^{i\varphi})|^pe^{-p\sigma r|\sin \varphi|}dr\right\}^{1/p}0} H^{p}_{\sigma}(\mathbb C_{+})
V.M. Dilnyi, T.I. Hishchak
doaj +1 more source
Iterated function systems and permutation representations of the Cuntz algebra
, 1996 We study a class of representations of the Cuntz algebras O_N, N=2,3,..., acting on L^2(T) where T=R/2\pi Z. The representations arise in wavelet theory, but are of independent interest.
Bratteli, Ola, Jorgensen, Palle E. T.
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Real-time PCR detection of PI*S and PI*Z alleles of SERPINA1 gene using SYBR green
GeneAlpha-1 antitrypsin deficiency is an underdiagnosed genetic condition that predisposes to pulmonary complications and is mainly caused by rs28929474 (PI*Z allele) and rs17580 (PI*S allele) mutations in the SERPINA1 gene.Development of a homogeneous genotyping test for detection of PI*S and PI*Z alleles based on the principles of allele-specific PCR and
González Carracedo, Mario Andrés +5 more
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source