Results 101 to 110 of about 4,228,114 (275)

Analysis of preliminary data on $e^+e^-\to\phi\to\gamma f_0(980)\to\gamma\pi^0\pi^0$ reaction

open access: yes, 1998
We perform the analysis of the preliminary data on $e^+e^-\to\phi\to\gamma f_0(980)\to\gamma\pi^0\pi^0$ reaction simultaneously with the data on $\pi\pi$ scattering and reactions $J/\psi\to\phi\pi^+\pi^-$ and $K^-p\to\pi^+\pi^-(\Lambda,\Sigma)$.
A. Falvard   +11 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Localized direct CP violation in $B^\pm\rightarrow \rho^0 (\omega)\pi^\pm\rightarrow \pi^+ \pi^-\pi^\pm$

open access: yes, 2015
We study the localized direct CP violation in the hadronic decays $B^\pm\rightarrow \rho^0 (\omega)\pi^\pm\rightarrow\pi^+ \pi^-\pi^\pm$, including the effect caused by an interesting mechanism involving the charge symmetry violating mixing between $\rho^
Guo, Xin-Heng   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Sensory remapping: a possible therapy option

open access: yesMedicina, 2023
The human sensory receptors are morphologically specialized to transduce specific stimuli into the brain. However, when an injury occurs, mainly in the spinal cord, which can be of traumatic or non-traumatic origin, it provokes various degrees of ...
Wanderson Silva Macedo de Sousa   +7 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Perfil sociodemográfico y clínico de las mujeres con síndrome hellp

open access: yesRevista de Enfermagem da Universidade Federal de Santa Maria, 2017
Objective: to describe the sociodemographic and clinical women with HELLP. Method: descriptive, quantitative approach of retrospective consists of all 52 records of women with HELLP syndrome from 2008 to 2012.
José Francisco Ribeiro   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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