Results 61 to 70 of about 626,720 (343)
Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]
, 2014 Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L. +4 more
core +5 more sources
Cancer Research, 2021 The dual PI3K/HDAC inhibitor BEBT-908 elicits potent anti-tumor responses, effectively inducing immunogenic ferroptosis of tumor cells and potentiating cancer immunotherapy.
F. Fan +11 more
semanticscholar +1 more source
Cold Spring Harbor Perspectives in Biology, 2012 Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled by a multi-step process that involves phosphoinositide-3-kinase (PI3K).
Brian A, Hemmings, David F, Restuccia
openaire +2 more sources
MTOR cross-talk in cancer and potential for combination therapy [PDF]
, 2018 The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C. +7 more
core +3 more sources
The present and future of PI3K inhibitors for cancer therapy
Nature Cancer, 2021 Phosphoinositide 3-kinase (PI3K) signaling regulates cellular proliferation, survival and metabolism, and its aberrant activation is one of the most frequent oncogenic events across human cancers.
P. Castel +3 more
semanticscholar +1 more source
PI3K Enters Beta-Testing [PDF]
Cell Metabolism, 2008 Phosphoinositide-3-OH kinases (PI3K) are critical regulators of cell metabolism, growth, and survival. In a recent publication in Nature, Jia et al. (2008) identify specific functions of the p110beta isoform of PI3K in glucose metabolism, cellular proliferation, and tumorigenesis.
Shaywitz, Adam J. +3 more
openaire +2 more sources
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
Signal Transduction and Targeted Therapy, 2021 Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation.
Chen Xue +3 more
semanticscholar +1 more source
SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta
Cells, 2022 SMER28 (Small molecule enhancer of Rapamycin 28) is an autophagy-inducing compound functioning by a hitherto unknown mechanism. Here, we confirm its autophagy-inducing effect by assessing classical autophagy-related parameters. Interestingly, we also discovered several additional effects of SMER28, including growth retardation and reduced G1 to S phase
Marco Kirchenwitz +9 more
openaire +4 more sources
A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT [PDF]
, 2016 Targeted cancer therapy aims to disrupt aberrant cellular signalling pathways. Biomarkers are surrogates of pathway state, but there is limited success in translating candidate biomarkers to clinical practice due to the intrinsic complexity of pathway ...
Boiko, Andrei +6 more
core +3 more sources
Plinabulin exerts an anti-proliferative effect via the PI3K/AKT/mTOR signaling pathways in glioblastoma [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Plinabulin, a marine-derived anticancer drug targeting microtubules, exhibits anti-cancer effects on glioblastoma cells. However, its therapeutic potential, specifically for glioblastoma treatment, remains underexplored.
Rouxin Wang +7 more
doaj +1 more source