Results 131 to 140 of about 64,413 (204)
Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis [PDF]
TRPV3 is a thermosensitive channel that is robustly expressed in skin keratinocytes and activated by innocuous thermal heating, membrane depolarization, and chemical agonists such as 2-aminoethyoxy diphenylborinate, carvacrol, and camphor.
Albert +93 more
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise +2 more
wiley +1 more source
eLife, 2017 FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane.
Julia P Steringer +14 more
doaj +1 more source
Controlled trial of cervical cancer screening frequency among human‐papillomavirus‐vaccinated women
International Journal of Cancer, Volume 158, Issue 7, Page 1941-1951, 1 April 2026.What's new? Since the introduction of the human papillomavirus (HPV) vaccine in 2006, vaccine‐type infections have declined markedly. As nonvaccine HPV types generally carry lower oncogenic potential, this shift warrants reevaluation of cervical screening regimens.
Mònica Ortega Llobet +10 more
wiley +1 more source
CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity
Glia, Volume 74, Issue 3, March 2026.CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert +14 more
wiley +1 more source
Journal of Peptide Science, Volume 32, Issue 3, March 2026.A predictive workflow enables accurate transfer from analytical HPLC to preparative FPLC for peptide purification. Systematic evaluation of key chromatographic parameters identified particle size, flow optimization and modifier choice as critical for selectivity and resolution. A correction model minimized elution transfer errors from −17% to less than
Alessandro Streuli +5 more
wiley +1 more source
Uncovering the Signaling Mechanisms of TransMEMbrane 16A [PDF]
, 2020 The Ca2+-activated Cl- channel, TransMEMbrane member 16A (TMEM16A), regulates diverse physiological functions including smooth muscle contraction, mucosal secretion and signal transduction. TMEM16A is an essential protein that we cannot live without.
Tembo, Maiwase
core
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Traffic, Volume 27, Issue 1, March 2026.Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang +7 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 2, Page 279-298, February 2026.Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey +2 more
wiley +1 more source
PIP5Kγ Mediates PI(4,5)P2/Merlin/LATS1 Signaling Activation and Interplays with Hsc70 in Hippo-YAP Pathway Regulation. [PDF]
Int J Mol Sci, 2023 Le DDT, Le TPH, Lee SY.
europepmc +1 more source