Results 141 to 150 of about 62,994 (190)

PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes. [PDF]

J Cell Biol, 2023
Pacheco J, Cassidy AC, Zewe JP, Wills RC, Hammond GRV.   +4 more
europepmc   +1 more source

The Polarized Redistribution of the Contractile Vacuole to the Rear of the Cell is Critical for Streaming and is Regulated by PI(4,5)P2-Mediated Exocytosis. [PDF]

Front Cell Dev Biol, 2021
Fadil SA, Janetopoulos C.
europepmc   +1 more source

A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P₂. [PDF]

Cells, 2023
Bura A, Čabrijan S, Đurić I, Bruketa T, Jurak Begonja A.   +4 more
europepmc   +1 more source

A novel homeostatic mechanism tunes PI(4,5)P2-dependent signaling at the plasma membrane.

J Cell Sci, 2023
Wills RC, Doyle CP, Zewe JP, Pacheco J, Hansen SD, Hammond GRV.   +5 more
europepmc   +1 more source

Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking

Abstract In p53-deficient cancers, targeting cholesterol metabolism has emerged as a promising therapeutic approach, given that p53 loss dysregulates sterol regulatory element-binding protein 2 (SREBP-2) pathways, thereby enhancing cholesterol biosynthesis.
Ryan M. Loughran, Gurpreet K. Arora, Jiachen Sun, Alicia Llorente, Sophia Crabtree, Kyanh Ly, Ren-Li Huynh, Wonhwa Cho, Brooke M. Emerling   +8 more
openaire   +2 more sources

Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating [PDF]

Pancreatology, 2015
József Maléth, Seok Choi, Malini Ahuja, Péter Hegyi, Shmuel Muallem   +4 more
openaire   +1 more source

Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. [PDF]

Elife, 2022
Lu J, Dong W, Hammond GR, Hong Y.
europepmc   +1 more source

Localization of the tubby domain, a PI(4,5)P2 biosensor, to E-Syt3-rich endoplasmic reticulum-plasma membrane junctions.

J Cell Sci, 2023
Thallmair V, Schultz L, Evers S, Jolie T, Goecke C, Leitner MG, Thallmair S, Oliver D.   +7 more
europepmc   +1 more source

The solute carrier SPNS2 recruits PI(4,5)P₂ to synergistically regulate transport of sphingosine-1-phosphate. [PDF]

Mol Cell, 2023
Tang H, Li H, Prakaash D, Pedebos C, Qiu X, Sauer DB, Khalid S, Duerr K, Robinson CV.   +8 more
europepmc   +1 more source

Phosphatases-mediated control of phosphatidylinositol 4,5-biphosphate [PI(4,5)P2] in plant cells

, 2020
Les phosphoinositides sont des lipides membranaires anioniques peu abondants .Leurs concentrations relatives dans les feuillets cytosoliques de la membrane plasmique et de certaines membranes internes des cellules eucaryotes constituent des signatures moléculaires.
openaire   +1 more source