Results 171 to 180 of about 62,994 (190)
MARCKS and PI(4,5)P2 reciprocally regulate actin-based dendritic spine morphology. [PDF]
Mol Biol CellCalabrese B, Halpain S.
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A distinctive PI(4,5)P2compartment forms during entosis and related engulfment processes
Durgan J +4 more
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Abstract 2510 Are MARCKS related proteins buffers of PI(4,5)P2?
Journal of Biological ChemistryJesus Calixto +2 more
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Disarming PI(4,5)P2 in the plasma membrane
Nature Plants, 2021Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is involved in lipid-mediated intracellular signalling and the regulation of events such as cytoskeletal reorganization and membrane trafficking. An inducible PI(4,5)P2 depletion system is now available for examining its function in plant cells.
Bo Liu, Xiaojiang Guo
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PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions
2023Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is the most abundant membrane phosphoinositide and cholesterol is an essential component of the plasma membrane (PM). Both lipids play key roles in a variety of cellular functions including as signaling molecules and major regulators of protein function.
Avia, Rosenhouse-Dantsker +2 more
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The PI(3,5)P2 and PI(4,5)P2 Interactomes
Journal of Proteome Research, 2008A comprehensive analysis of the phosphoinositide interactome has been performed using analogues of PI(3,5)P2 and PI(4,5)P2 phosphatidyl phospholipids which were immobilized onto Affi-10 beads or incorporated into liposomes for use as affinity absorbents with cytosolic extracts from colonic carcinoma cell lines.
Bruno, Catimel +8 more
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Mechanism of the Regulation of Plasma Cholesterol Levels by PI(4,5)P2
2023Elevated low-density lipoprotein (LDL) cholesterol (LDLc) is one of the most well-established risk factors for cardiovascular disease, while high levels of high-density lipoprotein (HDL) cholesterol (HDLc) have been associated with protection from cardiovascular disease.
Yuanyuan, Qin, Marisa W, Medina
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Role of PI(4,5)P2 and Cholesterol in Unconventional Protein Secretion
2023Besides its protective role in the maintenance of cell homeostasis, the plasma membrane is the site of exchanges between the cell interior and the extracellular medium. To circumvent the hydrophobic barrier formed by the acyl chains of the lipid bilayer, protein channels and transporters are key players in the exchange of small hydrophilic compounds ...
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Regulation of the Actin Cytoskeleton by PI(4,5)P2 and PI(3,4,5)P3
2004The actin cytoskeleton is fundamental for various motile and morphogenetic processes in cells. The structure and dynamics of the actin cytoskeleton are regulated by a wide array of actin-binding proteins, whose activities are controlled by various signal transduction pathways. Recent studies have shown that certain membrane phospholipids, especially PI(
P, Hilpelä +2 more
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Insights into the molecular recognition of the granuphilin C2A domain with PI(4,5)P2
Chemistry and Physics of Lipids, 2015Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a key player in regulating the process of excytosis, including insulin secretion. Granuphilin, a tandem C2 domain containing protein, mediates the docking of insulin granules onto plasma membrane. The C2A domain plays key roles in this process through interaction with PI(4,5)P2.
Chanjuan, Wan +9 more
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