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Regulation of the Actin Cytoskeleton by PI(4,5)P2 and PI(3,4,5)P3
2004The actin cytoskeleton is fundamental for various motile and morphogenetic processes in cells. The structure and dynamics of the actin cytoskeleton are regulated by a wide array of actin-binding proteins, whose activities are controlled by various signal transduction pathways. Recent studies have shown that certain membrane phospholipids, especially PI(
P, Hilpelä +2 more
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Role of PI(4,5)P2 and Cholesterol in Unconventional Protein Secretion
2023Besides its protective role in the maintenance of cell homeostasis, the plasma membrane is the site of exchanges between the cell interior and the extracellular medium. To circumvent the hydrophobic barrier formed by the acyl chains of the lipid bilayer, protein channels and transporters are key players in the exchange of small hydrophilic compounds ...
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Mechanism of the Regulation of Plasma Cholesterol Levels by PI(4,5)P2
2023Elevated low-density lipoprotein (LDL) cholesterol (LDLc) is one of the most well-established risk factors for cardiovascular disease, while high levels of high-density lipoprotein (HDL) cholesterol (HDLc) have been associated with protection from cardiovascular disease.
Yuanyuan, Qin, Marisa W, Medina
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Polyamines, PI(4,5)P2, and actin polymerization
Journal of Cellular Physiology, 2006AbstractSpermine (SPM) and spermidine (SPD) activate isolated phosphatidylinositol‐4‐phosphate 5‐kinases (PI(4)P5K), enzymes that convert phosphatidylinositol‐4‐phosphate to phosphatidylinositol 4,5‐bisphosphate (PI(4,5)P2). PI(4,5)P2 formation is known to be involved in cellular actin reorganization and motility, functions that are also influenced by ...
Ronald F, Coburn +2 more
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Advances in Biological Regulation, 2018
Inositol polyphosphate 5-phosphatases or phosphoinositide 5-phosphatases (PI 5-phosphatases) are enzymes that can act on soluble inositol phosphates and/or phosphoinositides (PIs). Several PI 5-phosphatases have been linked to human genetic diseases, in particular the Lowe protein or OCRL which is mutated in the Lowe syndrome.
Ramos, Ana Raquel +2 more
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Inositol polyphosphate 5-phosphatases or phosphoinositide 5-phosphatases (PI 5-phosphatases) are enzymes that can act on soluble inositol phosphates and/or phosphoinositides (PIs). Several PI 5-phosphatases have been linked to human genetic diseases, in particular the Lowe protein or OCRL which is mutated in the Lowe syndrome.
Ramos, Ana Raquel +2 more
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PI(4,5)P2 regulation of surface membrane traffic
Current Opinion in Cell Biology, 2001Phosphatidylinositol 4,5-biphosphate (PI[4,5]P(2)) has emerged as an important signaling molecule in the membrane for regulating vesicle exo- and endocytosis and the accompanying actin cytoskeletal rearrangements. Localization studies with GFP-tagged binding domains and antibodies provide new views of the non-uniform, dynamic distribution of PI(4,5)P(2)
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Cdc42 and PI(4,5)P2‐Induced Actin Assembly in Xenopus Egg Extracts
2006Xenopus egg cytoplasmic extracts have been used to study a variety of complex cellular processes. Given their amenability to biochemical manipulation and physiological balance of regulatory proteins, these extracts are an ideal system to dissect signal transduction pathways leading to actin assembly.
Andres M, Lebensohn +3 more
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PI4P and PI(4,5)P2 immunofluorescence staining optimization in human platelets
2021Background: Phosphatidylinositol-4-phosphate (PI4P) is a phosphoinositide found mostly at the Golgi apparatus and partially at the plasma membrane (PM). At the PM, PI4P can contribute to the polyanionic lipid pool or can serve for the formation of phosphatidylinositol-4, 5-bisphosphate [PI(4, 5)P2].
Bura, Ana +3 more
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Receptor induced PI(4,5)P2 dynamics in hippocampal CA1 pyramidal neurons
2014Das Plasmamembranlipid Phosphatidylinositol(4,5)biphosphat (PIP2) ist an der Regulation einer Vielzahl zellularer Prozesse beteiligt. Die Dynamik der PIP2-Konzentration in lebenden Zellen in ihrer nativen Umgebung ist bislang allerdings weitgehend unerforscht.
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