Results 61 to 70 of about 6,601 (222)

From small to big molecules: how do we prevent and delay the progression of age-related neurodegeneration? [PDF]

, 2012
Age-related neurodegeneration in the brain and retina is complicated. It comprises a series of events encompassing different modes of degeneration in neurons, as well as inflammation mediated by glial cells.
Chan, TF, Chang, RCC, Ho, YS, Poon, CHD
core   +1 more source

Characterization of Grape Cane Stilbenoids and Their Photo‐Degradation Products by HPLC‐DAD Coupled With Trapped Ion Mobility Spectrometry and High‐Resolution Tandem Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 40, Issue 15, 15 August 2026.
ABSTRACT Rationale Bioactive (E)‐stilbenoids in vine extracts are prone to light‐induced transformation into the respective (Z)‐isomers and further degradation products, often resulting in a loss of bioactivity. We sought to study stilbenoid degradation beyond that of the well‐researched resveratrol due to the high diversity of stilbenoids in nature ...
Paul Besrukow, Friederike A. Schnitker, Ralf Schweiggert, Christof B. Steingass   +3 more
wiley   +1 more source

Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria

Cellular Physiology and Biochemistry, 2016
Background/Aims: Resveratrol and its derivate piceatannol are known to induce cancer cell-specific cell death. While multiple mechanisms of actions have been described including the inhibition of ATP synthase, changes in mitochondrial membrane potential ...
Corina T. Madreiter-Sokolowski, Benjamin Gottschalk, Warisara Parichatikanond, Emrah Eroglu, Christiane Klec, Markus Waldeck-Weiermair, Roland Malli, Wolfgang F. Graier   +7 more
doaj   +1 more source

Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation [PDF]

, 2009
Background: OK-432, penicillin-killed Streptococcus pyogenes, is used in treating lymphangiomas and carcinomas. We have studied in vitro the role of mononuclear phagocytes (MNPs), including purified monocytes (MOs), in the immune response to OK-432.
Olsnes, Carla, Stavang, Helen Åse Margrethe, Brokstad, Karl Albert, Olofsson, Jan, Aarstad, Hans Jørgen   +4 more
core   +1 more source

Mechanistic Insights Into Ultrasound‐Assisted Plant Stilbenes Sustainable Extraction Using Hydrophilic NADES: A Case Study of Cajaninstilbene Acid With Integrated NMR, COSMO‐RS, and MD Simulation

Food Frontiers, Volume 7, Issue 3, May 2026.
Schematic illustration of green NADES extraction by using CSA as a model compound. ABSTRACT Stilbenes are bioactive phytochemicals with notable health benefits, yet their extraction is hindered by hydrophobicity and reliance on toxic solvents. This study introduces a green, sustainable approach for stilbene extraction using hydrophilic natural deep ...
Shanshan Zhang, Jun Wu, Renjie Niu, Qian Zhou, Mingfu Wang   +4 more
wiley   +1 more source

Therapeutic Role of Resveratrol and Piceatannol in Disease Prevention [PDF]

Journal of Blood Disorders & Transfusion, 2014
Resveratrol, (3,4’,5-trihydroxystilbene) has long been suspected to show a broad range of biological activities of medicinal interest such as anticancer, anti-oxidative, anti-diabetic, anti-aging and anti-inflammatory activities. Piceatannol (3,3’,4’,5-tetrahydroxystilbene) is a hydroxylated analogue of resveratrol and it confirms a lot of similar ...
Aayush Kukreja, Neha Wadhwa
openaire   +1 more source

Resveratrol for Cancer Radio‐Sensitization: Ready for Prime Time or Future Perspective

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Resveratrol exerts antioxidant and anti‐inflammatory effects by reducing reactive oxygen species and suppressing NF‐κB and JAK/STAT signaling pathways. It modulates metabolic signaling through AMPK‐dependent inhibition of mTOR, influencing cell survival and inflammatory responses.
Maryam Fallah, Ali Soleimani, Ali Nouri, Melika Fallah, Alireza Haghighi, Ahmad Reza Dehpour, Abolfazl Zendehdel, Soraiya Ebrahimpour‐Koujan   +7 more
wiley   +1 more source

Piceatannol bolsteres fetal haemoglobin formation in K562 cells via p38 map kinase activation and ERK inactivation [PDF]

Journal of BioScience and Biotechnology, 2015
Elevation of the level of fetal haemoglobin (HbF) by pharmacological agents is a safe and a promising approach for treating beta thalassemia. In this study, the effect of piceatannol was studied in human erythroleukemic K562 cells for their role in gamma-
AAYUSH KUKREJA, RAKESH ARYA , ARCHANA TIWARI   +2 more
doaj  

Endothelin-1 Induces Contraction via a Syk-Mediated p38 Mitogen-Activated Protein Kinase Pathway in Rat Aortic Smooth Muscle

Journal of Pharmacological Sciences, 2007
Although spleen tyrosine kinase (Syk) has crucial roles in various cells, its function on vascular smooth muscle contraction has not been determined. In the present study, we performed experiments to determine if Syk contributes to the endothelin-1 (ET-1)
Hwan Myung Lee, Kyung-Jong Won, Junghwan Kim, Hyo-Jun Park, Hyo Jin Kim, Hui Yul Roh, So Hee Lee, Chang-Kwon Lee, Bokyung Kim   +8 more
doaj   +1 more source

The Potential of Stilbene Compounds to Inhibit M^pro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019

Current Issues in Molecular Biology, 2022
COVID-19 disease has had a global impact on human health with increased levels of morbidity and mortality. There is an unmet need to design and produce effective antivirals to treat COVID-19.
Ayesha Naseem, Fatima Rasool, Abrar Ahmed, Wayne G. Carter   +3 more
doaj   +1 more source