Results 51 to 60 of about 3,444 (174)

Endothelin-1 Induces Contraction via a Syk-Mediated p38 Mitogen-Activated Protein Kinase Pathway in Rat Aortic Smooth Muscle

Journal of Pharmacological Sciences, 2007
Although spleen tyrosine kinase (Syk) has crucial roles in various cells, its function on vascular smooth muscle contraction has not been determined. In the present study, we performed experiments to determine if Syk contributes to the endothelin-1 (ET-1)
Hwan Myung Lee, Kyung-Jong Won, Junghwan Kim, Hyo-Jun Park, Hyo Jin Kim, Hui Yul Roh, So Hee Lee, Chang-Kwon Lee, Bokyung Kim   +8 more
doaj   +1 more source

The Potential of Stilbene Compounds to Inhibit M^pro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019

Current Issues in Molecular Biology, 2022
COVID-19 disease has had a global impact on human health with increased levels of morbidity and mortality. There is an unmet need to design and produce effective antivirals to treat COVID-19.
Ayesha Naseem, Fatima Rasool, Abrar Ahmed, Wayne G. Carter   +3 more
doaj   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Dehydration of Byrsonima cydoniifolia A. Juss. (Canjiqueira): influence of process variables on piceatannol retention [PDF]

Brazilian Journal of Biology
This study evaluated the retention of piceatannol and the cytotoxicity of Byrsonima cydoniifolia A. Juss. pulp, both fresh and dehydrated, under different temperature and storage conditions.
V. S. Oliveira, J. R. Donadon, R. C. A. Guimarães, W. H. Kato Junior, T. O. Anastácio, L. M. Silva, P. O. Figueiredo, C. A. L. Cardoso, D. Bogo, V. A. Nascimento, K. C. Freitas, P. A. Hiane   +11 more
doaj   +1 more source

The Bark of the Spruce Picea jezoensis Is a Rich Source of Stilbenes

Metabolites, 2021
Stilbenes are plant phenolic secondary metabolites that show beneficial effects on human health and possess high antifungal activity against plant pathogens.
Andrey R. Suprun, Alexandra S. Dubrovina, Olga A. Aleynova, Konstantin V. Kiselev   +3 more
doaj   +1 more source

Antioxidants in Plant‐Based Food Matrices: From Structure–Activity and Degradation Kinetics to Formulation Design

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 4, July 2026.
ABSTRACT Plant‐based antioxidants are widely incorporated into foods to retard oxidative deterioration and to deliver health‐related benefits. Yet, their in‐product and in vivo performance frequently diverges from predictions based on solution‐phase chemical assays, because matrix interactions, processing history, and host metabolism reshape both ...
Márcio Vargas‐Ramella, Carmen Silvia Favaro‐Trindade, Bárbara Miranda‐Vilela, Mariana Estefanuto‐Costa, Marina Franco‐Brito, Bibiana Alves dos Santos, Paulo Cezar Bastianello Campagnol   +6 more
wiley   +1 more source

Genomic and Transcriptomic Analyses Provide Insights Into Erysiphe necator Pathogenicity and Grapevine Response

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4599-4618, July 2026.
ABSTRACT Grapevine powdery mildew, caused by the fungus Erysiphe necator, is one of the most prevalent obligate biotrophic pathogens in vineyards, posing a significant threat to grape production. Despite its impact, research on E. necator pathogenicity and grapevine responses remains limited.
Bo Mu, Ruixin Tang, Zhaolin Teng, Jinfu Chen, Kaicheng Cui, Feng Wei, Wenxiang Kong, Shunyuan Xiao, Xiangnan Xu, Jia‐Yue Feng, Ying‐Qiang Wen   +10 more
wiley   +1 more source

Production of Anti-Cancer Agent Using Microbial Biotransformation

Molecules, 2014
Microbial biotransformation is a great model system to produce drugs and biologically active compounds. In this study, we elucidated the fermentation and production of an anti-cancer agent from a microbial process for regiospecific hydroxylation of ...
Changhyun Roh, ChanKyu Kang
doaj   +1 more source

The Early Response to Urea, Nitrate, or Ammonium and Iron Resupply in Tomato Roots Highlights the Induction of FER, bHLHs, UMAMITs, and MATEs

Physiologia Plantarum, Volume 178, Issue 4, July/August 2026.
ABSTRACT Depending on the nitrogen (N) form available to roots, plants activate different transcriptional and metabolic pathways; this can consequently translate into differences in the composition and release of root exudates. To address the existing knowledge gap regarding the relationship between the availability of Iron (Fe) and different N forms ...
Arianna Lodovici, Leilei Zhang, Nicola Tomasi, Gabriella Vinci, Fabio Marroni, Barbara Piani, Fatemeh Hassanvand, Mustapha Arkoun, Luigi Lucini, Laura Zanin   +9 more
wiley   +1 more source

Preparation, Component Identification, and Antioxidant Activity of Anthocyanins From Punica granatum “Tunisia”

AgriFood: Journal of Agricultural Products for Food, Volume 2, Issue 2, Page 127-140, June 2026.
The preparation for Tunisian pomegranate anthocyanin extract. The molecular mechanisms underlying the antioxidant effects of these compounds were investigated using network pharmacology and molecular docking. Antioxidant activity was evaluated through DPPH, ABTS, and FRAP assays, whereas the effects on oxidative stress and inflammation were examined in
Jing Zhang, Xu‐han Yang, Meng‐qi Zhang, Xu Guo, Ning‐yang Li, Fang‐yu Long, Chao Liu   +6 more
wiley   +1 more source