Biomedicines, 2023 Oxidative stress and epigenetic alterations, including the overexpression of all class I and II histone deacetylases (HDACs), particularly HDAC2 and HDAC4, have been identified as key molecular mechanisms driving pulmonary fibrosis.
Nehal Ezz Eldeen +4 more
doaj +1 more source
Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk [PDF]
, 2018 β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription.
Bhardwaj, Deepshikha +6 more
core +3 more sources
Involvement of 5′AMP-Activated Protein Kinase (AMPK) in the Effects of Resveratrol on Liver Steatosis [PDF]
, 2018 This review focuses on the role of 5'-activated protein kinase (AMPK) in the effects of resveratrol (RSV) and some RSV derivatives on hepatic steatosis. In vitro studies, performed in different hepatic cell models, have demonstrated that RSV is effective
Eseberri Barace, Itziar +6 more
core +3 more sources
Investigation of Stilbenoids as Potential Therapeutic Agents for Rotavirus Gastroenteritis [PDF]
, 2015 Rotavirus (RV) infections cause severe diarrhea in infants and young children worldwide. Vaccines are available but cost prohibitive for many countries and only reduce severe symptoms. Vaccinated infants continue to shed infectious particles, and studies
Atwill, Richard L. +10 more
core +3 more sources
Piceatannol Induces Mitochondrial Dysfunction in <i>Toxoplasma gondii</i>. [PDF]
MicroorganismsToxoplasma gondii, an obligate intracellular protozoan parasite infecting nucleated cells of warm-blooded vertebrates, causes severe complications in immunocompromised hosts. Current therapies remain limited by suboptimal efficacy and toxicity, necessitating novel anti-toxoplasmic agents.
Liu Z +7 more
europepmc +4 more sources
ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia [PDF]
, 2016 This work was supported by funds from the Wellcome Trust (098291/Z/12/Z and 101604/Z/13/Z) (S.N.) and the British Heart Foundation (FS/11/19/28761) (A.W.)
Abigail Woodfin +80 more
core +1 more source
Clinical and Translational Medicine, 2021 Inflammatory bowel disease (IBD) has emerged a global disease and the ascending incidence and prevalence is accompanied by elevated morbidity, mortality, and substantial healthcare system costs.
Wenbin Gong +12 more
doaj +1 more source
Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. [PDF]
, 2015 Sirtuin (Sirt) 1 and Sirt 3 are nicotinamide adenine dinucleotide ((+))-dependent protein deacetylases that are important to a number of mitochondrial-related functions; thus, identification of sirtuin activators is important. Herein, we hypothesize that
Arguelles, Andrix +6 more
core +1 more source
The occurrence of the stilbene piceatannol in grapes
, 2002 Piceatannol (trans-3,3',4,5'-tetrahydroxy-stilbene) is a natural stilbene occurring in a number of plant species, and it has been shown to have beneficial effects on human health. The compound can seldom be consumed by humans, because it occurs in non-food plants, or in non-edible organs.
Bavaresco, L. +5 more
openaire +3 more sources
Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts [PDF]
Royal Society Open Science, 2019 Osteoclasts are multinuclear giant cells that have unique ability to degrade bone. The search for new medicines that modulate the formation and function of osteoclasts is a potential approach for treating osteoclast-related bone diseases.
Liuliu Yan +4 more
doaj +1 more source