Antiglycation of Insulin by Selected Six Bioactive Peanut Sprout Stilbenoids and Demonstration of Methylglyoxal-Mediated Biphasic Insulin Glycation by <i>O</i>-Phenylenediamine Derivatization. [PDF]
Food Sci NutrGraphical abstract demonstrates 6 peanut sprout containing stilbenoids exhibiting varied structure‐activity potency in protection of insulin integrity from glycation mediated by methylglyoxal (MG), glucose and fructose. Meanwhile, MG‐mediated biphasic insulin glycation was evidenced in Tricine SDS‐PAGE analysis and supported by O‐phenylenediamine (OPD)
Chiu PC, Lin SM, Li YJ, Lo CY, Chiou RY.
europepmc +2 more sources
Identification of Pyrazolidine-3-One Derivatives as a Novel Structural Scaffold for ATP Synthase Inhibitors. [PDF]
ChemMedChemFollowing the discovery of oxadiazin‐5‐ones as partial inhibitors of the ATP synthase, we herein report the synthesis of a library of pyrazolidine‐3‐ones and pyrazol‐3‐ones, designed by reducing the six‐membered N–N heterocycles to five‐membered rings.
Reichert L +8 more
europepmc +2 more sources
Leishmanicidal Effect of Synthetic trans-Resveratrol Analogs. [PDF]
PLoS ONE, 2015 Stilbene-based compounds show antitumoral, antioxidant, antihistaminic, anti-inflammatory and antimicrobial activities. Here, we evaluated the effect of the trans-resveratrol analogs, pterostilbene, piceatannol, polydatin and oxyresveratrol, against ...
Carlos Luan Alves Passos +3 more
doaj +1 more source
The cancer preventive activity and mechanisms of prenylated resveratrol and derivatives
Current Research in Toxicology, 2023 Resveratrol is regarded as neutraceuticals with multiple health benefits. The introduction of prenyl can enhance the bioactivity. In this work, the cancer preventive activities and mechanisms of 18 prenylated reseveratrol and derivatives were ...
Ting Zhou +3 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate how piceatannol enhances the anti-tumor effect of cisplatin on laryngeal cancer cells and related molecular mechanism. Methods Laryngeal carcinoma Hep-2 cells were cultured in vitro and then treated with piceatannol and cisplatin.
DUAN Chuanxin
doaj +1 more source
Molecules, 2023 4-Hydroxyphenylacetate-3-hydroxylase (4HPA3H; EC 1.14.14.9) is a heterodimeric flavin-dependent monooxygenase complex that catalyzes the ortho-hydroxylation of resveratrol to produce piceatannol.
Qianchao Zhang +8 more
doaj +1 more source
Piceatannol attenuates fat accumulation and oxidative stress in steatosis-induced HepG2 cells
Current Research in Food Science, 2020 Non-alcoholic fatty liver disease (NAFLD), which affects over 20% of the adult population, is the most common liver disease worldwide and can progress to inflammatory hepatitis, cirrhosis and liver cancer.
Jason Szuhao Yang +3 more
doaj +1 more source
Diversity and characteristics of culturable endophytic bacteria from Passiflora edulis seeds
MicrobiologyOpen, 2021 Defense compounds generally inhibit microbial colonization of plants. In this study, we examined the presence of endophytes in Passiflora edulis seeds that accumulate resveratrol and piceatannol at extremely high levels as defense compounds ...
Aoi Ishida, Toshiki Furuya
doaj +1 more source
Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress [PDF]
, 2020 Piceatannol is a resveratrol metabolite that is considered a potent antioxidant and cytoprotector because of its high capacity to chelate/sequester reactive oxygen species. In pathogenesis of periodontal diseases, the imbalance of reactive oxygen species
Mitre, Geovanni Pereira +12 more
core +2 more sources
A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]
, 2003 A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Walzog, Barbara +4 more
core +1 more source