Results 101 to 110 of about 979 (130)

Neurochemical changes in brains of mice infected with Pichinde virus

Medical Microbiology and Immunology, 1986
A D T Barrett, J A Johnson, A J Cross
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Strandedness of Pichinde virus RNA

Journal of Virology, 1977
The Pichinde virus RNA did not possess the following characteristics of eucaryotic mRNA: polyadenylic acid sequence, capped methylated structure, and ability to direct protein synthesis in vitro. Polysomal RNA extracted from cells infected with Pichinde virus reannealed with 32P-labeled virus RNA, protecting about 60% of the latter against RNase ...
W C, Leung, H P, Ghosh, W E, Rawls
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Polypeptide Synthesis Catalysed by Components of Pichinde Virus Disrupted by Detergent

Journal of General Virology, 1981
Pichinde virus preparations were investigated for ribosomal components and associated activities. After detergent treatment and fractionation, viral components were assayed for polypeptide synthesis, elongation of nascent polypeptide chains, and mRNA activity.
Herbert A Thompson
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The nucleoprotein of Pichinde virus expressed by a vaccinia-Pichinde virus recombinant partially protects hamsters from lethal virus challenge

Archives of Virology, 1994
Syrian hamsters, strain MHA/Lak, are susceptible to intraperitoneal infection with Pichinde virus and die from an overwhelming viremia. We have studied the ability of a vaccinia-Pichinde recombinant virus expressing amino acids 51-561 of the viral nucleoprotein (VVNP51-561) to protect from lethal Pichinde virus infection.
D Y, Ozols, W E, Rawls, K L, Rosenthal, D G, Harnish   +3 more
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Characterization of temperature-sensitive mutants of Pichinde virus

Journal of Virology, 1988
The synthesis of viral proteins and S RNAs in cells infected with 12 temperature-sensitive (ts) mutants of Pichinde virus was characterized. The mutants could be divided into five groups on the basis of the patterns of radiolabeled proteins immunoprecipitated from infected-cell lysates.
M, Shivaprakash, D, Harnish, W, Rawls
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Regulation of Pichinde virus replication in Vero and BHK-21 cells

Medical Microbiology and Immunology, 1986
Paul R Young, C R Howard
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Characterization of Pichinde virus infection of cells of the monocytic lineage

Journal of Virology, 1991
To establish a model of viral infection of monocytes, we examined infection of human cells and cell lines of the monocytic series with the arenavirus Pichinde virus. We demonstrate for the first time that human peripheral blood monocytes are susceptible to Pichinde virus infection, as shown by immunoprecipatation of virus-specific polypeptides from ...
S J, Polyak, W E, Rawls, D G, Harnish
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Virion-associated ribosomes are not required for the replication of Pichinde virus

Virology, 1977
Abstract Ribosomes of host cell origin have been isolated from Pichinde virus. A cell mutant with a temperature-sensitive defect in protein synthesis and 60 S ribosomal subunits was employed to study the role of virion-associated ribosomes in the replication of Pichinde virus. Virions carrying the temperature-sensitive ribosomes replicated as well at
W C, Leung, W E, Rawls
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Persistent infection of mice with Pichinde virus associated with failure to thrive

Microbial Pathogenesis, 1995
Intracranial inoculation of neonatal mice of certain inbred strains with Pichinde virus has been found to be fatal, but Balb/c neonates survive such infection. Survival of Balb/c mice after neonatal inoculation was not linked to the major histocompatability complex. Virus was gradually cleared in surviving Balb/c mice but could be detected in the brain
K E, Wright, R, Ahmed, M J, Buchmeier
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Susceptibility to Fatal Pichinde Virus Infection in the Syrian Hamster

1981
The data presented in this paper suggest that the susceptible MHA hamster strain possesses a spleen target cell for Pichinde virus replication which is minimally expressed in the resistant strain. This target cell co-purifies with cells mediating NK activity, raising the possibility that the NK cell itself may be the additional target cell for Pichinde
S R, Gee, M A, Chan, D A, Clark, W E, Rawls   +3 more
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