Results 81 to 90 of about 1,551 (170)

Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog.

PLoS ONE, 2010
BackgroundA growing number of arenaviruses can cause a devastating viral hemorrhagic fever (VHF) syndrome. They pose a public health threat as emerging viruses and because of their potential use as bioterror agents. All of the highly pathogenic New World
Brian B Gowen, Min-Hui Wong, Deanna Larson, Wei Ye, Kie-Hoon Jung, Eric J Sefing, Ramona Skirpstunas, Donald F Smee, John D Morrey, Stewart W Schneller   +9 more
doaj   +1 more source

Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components [PDF]

, 2016
The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions.
Bosch, Irene, Braff, Dana, Collins, James J., Daringer, Nichole Marie, Donghia, Nina, Dudley, Dawn M., Fan, Melina, Ferrante, Tom, Gehrke, Lee, Green, Alexander A., Lambert, Guillaume, Lee, Jeongwook, Ma, Duo, O’Connor, David H., Pardee, Keith, Takahashi, Melissa Kimie   +15 more
core   +1 more source

Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin.

PLoS ONE, 2008
A growing number of arenaviruses are known to cause viral hemorrhagic fever (HF), a severe and life-threatening syndrome characterized by fever, malaise, and increased vascular permeability.
Brian B Gowen, Donald F Smee, Min-Hui Wong, Jeffery O Hall, Kie-Hoon Jung, Kevin W Bailey, John R Stevens, Yousuke Furuta, John D Morrey   +8 more
doaj   +1 more source

Lassa Fever in Post-Conflict Sierra Leone [PDF]

, 2014
Background: Lassa fever (LF), an often-fatal hemorrhagic disease caused by Lassa virus (LASV), is a major public health threat in West Africa. When the violent civil conflict in Sierra Leone (1991 to 2002) ended, an international consortium assisted in ...
Abigail B. Jones, Alex Matschiner, Allyson M. Haislip, Augustine Goba, Bethany L. Brown, Christian T. Happi, Christopher M. Bishop, Daniel G. Bausch, Danielle C. Levy, Darin Ottomassathien, Darryl B. Sampey, Deborah H. Elliot, Donald S. Grant, Erica Ollmann Saphire, F. Jon Geske, Hu Zhu, Ivana J. Muncy, James E. Robinson, Jeffrey G. Shaffer, Jennifer S. Spence, Jessica N. Hartnett, Joan B. Geisbert, John S. Schieffelin, Kandeh Kargbo, Kathryn M. Hastie, Kelly R. Pitts, Kristian G. Andersen, Lansana Kanneh, Lee A. Henderson, Lina M. Moses, Luis M. Branco, Mambo Momoh, Mathew Stremlau, Matt L. Boisen, Mbalu Fonnie, Megan M. Illick, Mohammed Fullah, null null, Onikepe A. Folarin, Pardis C. Sabeti, Peter C. Kulakosky, Rachael E. Yenni, Richard Fonnie, Ridhi Tariyal, Robert F. Garry, Robert W. Cross, Russell B. Wilson, S. Humarr Khan, Shervin Tabrizi, Stephen K. Gire, Thomas W. Geisbert, Veronica J. Koroma   +51 more
core   +3 more sources

Polypeptide Synthesis Catalysed by Components of Pichinde Virus Disrupted by Detergent

Journal of General Virology, 1981
Pichinde virus preparations were investigated for ribosomal components and associated activities. After detergent treatment and fractionation, viral components were assayed for polypeptide synthesis, elongation of nascent polypeptide chains, and mRNA activity.
D N, Chinault, H A, Thompson, J D, Gangemi   +2 more
openaire   +2 more sources

Fiebres hemorrágicas por Arenavirus en Latinoamérica

Salud Uninorte, 2010
Las fiebres hemorrágicas virales producidas por Arenavirus incluyen a los virus endémicos en África (Lassa) y el virus de la coriomeningitis linfocítica (LCMV), de distribución mundial, y los Arenavirus del Nuevo Mundo o Complejo Tacaribe, que incluye a ...
Ella Soto, Salim Mattar
doaj  

Topographical mapping of epitopes on the glycoproteins of murine hepatitis virus-4 (strain JHM): correlation with biological activities. [PDF]

, 1984
Monoclonal hybridoma antibodies (MAb) of defined polypeptide specificity and biological activity were used in a competition binding assay to identify antibody binding sites (epitopes) on the glycoproteins of murine hepatitis virus-4 strain JHM (MHV-4 ...
Buchmeier, MJ, Knobler, RL, Salmi, AA, Talbot, PJ   +3 more
core  

Investigation of type-I interferon dysregulation by arenaviruses : a multidisciplinary approach. [PDF]

, 2011
This report provides a detailed overview of the work performed for project number 130781, 'A Systems Biology Approach to Understanding Viral Hemorrhagic Fever Pathogenesis.' We report progress in five key areas: single cell isolation devices and control ...
Branda, Catherine, Carson, Bryan D., James, Conrad D., Kozina, Carol L., Manginell, Ronald Paul, Misra, Milind, Moorman, Matthew Wallace, Negrete, Oscar A., Ricken, James Bryce, Wu, Meiye   +9 more
core   +1 more source

Tumor Necrosis Factor and the Pathogenesis of Pichinde Virus Infection in Guinea Pigs [PDF]

The American Society of Tropical Medicine and Hygiene, 1995
Pichinde virus (PIC) is a reticuloendothelial arenavirus of the New World tropics. A guinea pig passage–adapted strain of this virus (adPIC) is uniformly lethal for inbred guinea pigs, while the related, prototype strain (PIC3739) has attenuated virulence.
J F, Aronson, N K, Herzog, T R, Jerrells
openaire   +2 more sources

Arenavirus: su interacción con la célula hospedadora [PDF]

, 2011
Con la finalidad de encarar el estudio de los eventos moleculares en las infecciones por arenavirus, es necesario conocer previamente aspectos biológicos básicos de la replicación de estos virus y de su interacción con la célula hospedadora.
López, Ricardo A.
core   +3 more sources