Prophylactic and post-exposure efficacy of a Pichinde virus vector-based tuberculosis vaccine
Frontiers in ImmunologyMycobacterium tuberculosis (Mtb) remains the leading cause of death from a single infectious agent, despite the availability of the Bacillus Calmette-Guérin (BCG) vaccine and antibiotic therapies.
Michaela Cain +8 more
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PLoS ONE, 2008 A growing number of arenaviruses are known to cause viral hemorrhagic fever (HF), a severe and life-threatening syndrome characterized by fever, malaise, and increased vascular permeability.
Brian B Gowen +8 more
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Fiebres hemorrágicas por Arenavirus en Latinoamérica
Salud Uninorte, 2010 Las fiebres hemorrágicas virales producidas por Arenavirus incluyen a los virus endémicos en África (Lassa) y el virus de la coriomeningitis linfocítica (LCMV), de distribución mundial, y los Arenavirus del Nuevo Mundo o Complejo Tacaribe, que incluye a ...
Ella Soto, Salim Mattar
doaj
Reassortant Analysis of Guinea Pig Virulence of Pichinde Virus Variants
Virology, 2001 The new world arenavirus Pichinde (PIC) is the basis of an accepted small animal model for human Lassa fever. PIC (Munchique strain) variant P2 is attenuated in guinea pigs, whereas variant P18 is extremely virulent. Previous sequence analysis of the S segments of these two viruses indicated a small number of possible virulence markers in the ...
Zhang, Lihong +3 more
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Pathogenesis of a Pichinde Virus Strain Adapted to Produce Lethal Infections in Guinea Pigs [PDF]
Infection and Immunity, 1981 A model for studying the pathogenesis of virulent arenavirus infection was developed by adapting Pichinde virus to produce lethal infections of inbred guinea pigs. This adapted Pichinde virus retained low virulence for primates, thus potentially reducing the biohazard to investigators.
P B, Jahrling +4 more
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The RNAs of Defective Interfering Pichinde Virus
Journal of General Virology, 1976 A Pichinde persitently infected BHK21/13S culture was established in which defective interfering (DI) virus continued to be synthesized after cessation of plaque-forming virus replication. This DI virus, concentrated from NaCl-polyethylene glycol treated tissue culture fluids, was shown to band over a much broader range than standard virus, in either ...
F J, Dutko, E A, Wright, C J, Pfau
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Size Estimation of Pichinde Virus RNA by Gel Electrophoresis under Denaturing Conditions
Intervirology, 1980 RNA extracted from purified Pichinde virion preparations yields four major species, two of which appear to represent the viral genome while the other two appear to be cellular ribosomal 28S and 18S RNA. The molecular weights of these RNA species have been estimated by gel electrophoresis following denaturation by either methylmercury or glyoxal ...
A I, Ramsingh +3 more
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Characterization of the host response to pichinde virus infection in the Syrian golden hamster by species-specific kinome analysis. [PDF]
Mol Cell Proteomics, 2015 Falcinelli S +10 more
europepmc +1 more source
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain. [PDF]
J Virol, 2015 Xing J, Chai Z, Ly H, Liang Y.
europepmc +1 more source
A Novel Live Pichinde Virus-Based Vaccine Vector Induces Enhanced Humoral and Cellular Immunity after a Booster Dose. [PDF]
J Virol, 2015 Dhanwani R +6 more
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