Results 61 to 70 of about 1,551 (170)

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer [PDF]

, 2016
Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves important roles in physiology by sculpting complex tissues during embryogenesis and by removing effete cells that have reached advanced age or whose genomes ...
Barcinski, M, Birge, RB, Boeltz, S, Brekken, RA, Calianese, D, Carlson, J, Empig, C, Freimark, B, Herrmann, M, Huang, X, Hutchins, JT, Kumar, S, Mercer, J, Schett, G, Schroit, AJ, Wanderley, J   +15 more
core   +1 more source

Effects of Actinomycin D and Ultraviolet and Ionizing Radiation on Pichinde Virus [PDF]

Journal of Virology, 1973
Actinomycin D (0.05 μg/ml) suppresses the synthesis of ribosomal RNA of baby hamster kidney (BHK21) cells. The production of infectious Pichinde virus was enhanced in the presence of actinomycin D, although the production of virus particles was not substantially different from cultures inoculated in the absence of the drug.
M F, Carter, F A, Murphy, J P, Brunschwig, C, Noonan, W E, Rawls   +4 more
openaire   +2 more sources

Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of Phosphatidylserine as a Main Regulator

Journal of Parasitology Research, Volume 2012, Issue 1, 2012., 2012
Leishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. The poor activation of an effective cellular response is correlated with the ability of these parasites to infect mononuclear phagocytic cells without triggering their activation ...
Joao Luiz Mendes Wanderley, Jaqueline França Costa, Valéria Matos Borges, Marcello Barcinski, Marcela F. Lopes   +4 more
wiley   +1 more source

Antiviral activity of ribosome-inactivating proteins [PDF]

, 2021
Producción CientíficaRibosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis.
Citores González, Lucía, Ferreras Rodríguez, José Miguel, Iglesias Álvarez, María del Rosario   +2 more
core   +1 more source

Synthesis of virus-specific polypeptides and genomic RNA during the replicative cycle of Pichinde virus [PDF]

Journal of Virology, 1982
A stock of plaque-purified Pichinde virus, prepared under conditions designed to limit the amounts of defective interfering virus, was used to infect BHK cells. At daily intervals after infection, cells were examined for infectious and radiolabeled virus particle production and for the synthesis of virus-specific polypeptides.
K, Dimock, D G, Harnish, G, Sisson, W C, Leung, W E, Rawls   +4 more
openaire   +2 more sources

Arenavirus Budding

Advances in Virology, Volume 2011, Issue 1, 2011., 2011
Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus‐host interactions and associated disease.
Shuzo Urata, Juan Carlos de la Torre, Fadila Bouamr   +2 more
wiley   +1 more source

Reassortant Analysis of Guinea Pig Virulence of Pichinde Virus Variants

Virology, 2001
The new world arenavirus Pichinde (PIC) is the basis of an accepted small animal model for human Lassa fever. PIC (Munchique strain) variant P2 is attenuated in guinea pigs, whereas variant P18 is extremely virulent. Previous sequence analysis of the S segments of these two viruses indicated a small number of possible virulence markers in the ...
Zhang, Lihong, Marriott, Kathleen A., Harnish, Delsworth G., Aronson, Judith F.   +3 more
openaire   +2 more sources

Role of natural killer cells in Pichinde virus infection of Syrian hamsters [PDF]

Infection and Immunity, 1981
Pichinde virus produced a fatal infection in adult MHA hamsters but not LSH hamsters after intraperitoneal inoculation. After footpad inoculation, an 8-day swelling response was observed in LSH but not MHA hamsters; however, both strains survived infection by this route.
S R, Gee, M A, Chan, D A, Clark, W E, Rawls   +3 more
openaire   +2 more sources

Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development

BioMed Research International, Volume 2010, Issue 1, 2010., 2010
Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure. The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential returns for industry. However, a number of tools, from
Gavin C. Bowick, Alan D. T. Barrett, Yongqun Oliver He   +2 more
wiley   +1 more source

mTOR Regulation of Lymphoid Cells in Immunity to Pathogens [PDF]

, 2016
Immunity to pathogens exists as a fine balance between promoting activation and expansion of effector cells, while simultaneously limiting normal and aberrant responses. These seemingly opposing functions are kept in check by immune regulators.
Maureen Ann McGargill, Rachael Keating
core   +2 more sources