Results 61 to 70 of about 981 (132)

Role of natural killer cells in Pichinde virus infection of Syrian hamsters [PDF]

Infection and Immunity, 1981
Pichinde virus produced a fatal infection in adult MHA hamsters but not LSH hamsters after intraperitoneal inoculation. After footpad inoculation, an 8-day swelling response was observed in LSH but not MHA hamsters; however, both strains survived infection by this route.
S R, Gee, M A, Chan, D A, Clark, W E, Rawls   +3 more
openaire   +2 more sources

Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog.

PLoS ONE, 2010
BackgroundA growing number of arenaviruses can cause a devastating viral hemorrhagic fever (VHF) syndrome. They pose a public health threat as emerging viruses and because of their potential use as bioterror agents. All of the highly pathogenic New World
Brian B Gowen, Min-Hui Wong, Deanna Larson, Wei Ye, Kie-Hoon Jung, Eric J Sefing, Ramona Skirpstunas, Donald F Smee, John D Morrey, Stewart W Schneller   +9 more
doaj   +1 more source

Polypeptide Synthesis Catalysed by Components of Pichinde Virus Disrupted by Detergent

Journal of General Virology, 1981
Pichinde virus preparations were investigated for ribosomal components and associated activities. After detergent treatment and fractionation, viral components were assayed for polypeptide synthesis, elongation of nascent polypeptide chains, and mRNA activity.
D N, Chinault, H A, Thompson, J D, Gangemi   +2 more
openaire   +2 more sources

Fiebres hemorrágicas por Arenavirus en Latinoamérica

Salud Uninorte, 2010
Las fiebres hemorrágicas virales producidas por Arenavirus incluyen a los virus endémicos en África (Lassa) y el virus de la coriomeningitis linfocítica (LCMV), de distribución mundial, y los Arenavirus del Nuevo Mundo o Complejo Tacaribe, que incluye a ...
Ella Soto, Salim Mattar
doaj  

Prophylactic and post-exposure efficacy of a Pichinde virus vector-based tuberculosis vaccine

Frontiers in Immunology
Mycobacterium tuberculosis (Mtb) remains the leading cause of death from a single infectious agent, despite the availability of the Bacillus Calmette-Guérin (BCG) vaccine and antibiotic therapies.
Michaela Cain, Alisha M. Block, Qinfeng Huang, Natalie M. Kirk, Hannah Murphy, Macallister C. Harris, Hinh Ly, Anna D. Tischler, Yuying Liang   +8 more
doaj   +1 more source

Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin.

PLoS ONE, 2008
A growing number of arenaviruses are known to cause viral hemorrhagic fever (HF), a severe and life-threatening syndrome characterized by fever, malaise, and increased vascular permeability.
Brian B Gowen, Donald F Smee, Min-Hui Wong, Jeffery O Hall, Kie-Hoon Jung, Kevin W Bailey, John R Stevens, Yousuke Furuta, John D Morrey   +8 more
doaj   +1 more source

Reassortant Analysis of Guinea Pig Virulence of Pichinde Virus Variants

Virology, 2001
The new world arenavirus Pichinde (PIC) is the basis of an accepted small animal model for human Lassa fever. PIC (Munchique strain) variant P2 is attenuated in guinea pigs, whereas variant P18 is extremely virulent. Previous sequence analysis of the S segments of these two viruses indicated a small number of possible virulence markers in the ...
Zhang, Lihong, Marriott, Kathleen A., Harnish, Delsworth G., Aronson, Judith F.   +3 more
openaire   +2 more sources

Pathogenesis of a Pichinde Virus Strain Adapted to Produce Lethal Infections in Guinea Pigs [PDF]

Infection and Immunity, 1981
A model for studying the pathogenesis of virulent arenavirus infection was developed by adapting Pichinde virus to produce lethal infections of inbred guinea pigs. This adapted Pichinde virus retained low virulence for primates, thus potentially reducing the biohazard to investigators.
P B, Jahrling, R A, Hesse, J B, Rhoderick, M A, Elwell, J B, Moe   +4 more
openaire   +2 more sources

The RNAs of Defective Interfering Pichinde Virus

Journal of General Virology, 1976
A Pichinde persitently infected BHK21/13S culture was established in which defective interfering (DI) virus continued to be synthesized after cessation of plaque-forming virus replication. This DI virus, concentrated from NaCl-polyethylene glycol treated tissue culture fluids, was shown to band over a much broader range than standard virus, in either ...
F J, Dutko, E A, Wright, C J, Pfau
openaire   +2 more sources

Size Estimation of Pichinde Virus RNA by Gel Electrophoresis under Denaturing Conditions

Intervirology, 1980
RNA extracted from purified Pichinde virion preparations yields four major species, two of which appear to represent the viral genome while the other two appear to be cellular ribosomal 28S and 18S RNA. The molecular weights of these RNA species have been estimated by gel electrophoresis following denaturation by either methylmercury or glyoxal ...
A I, Ramsingh, K, Dimock, W E, Rawls, W C, Leung   +3 more
openaire   +2 more sources