Results 51 to 60 of about 981 (132)
Advances in Virology, Volume 2011, Issue 1, 2011., 2011 Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus‐host interactions and associated disease.
Shuzo Urata +2 more
wiley +1 more source
Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development
BioMed Research International, Volume 2010, Issue 1, 2010., 2010 Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure. The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential returns for industry. However, a number of tools, from
Gavin C. Bowick +2 more
wiley +1 more source
Synthesis of virus-specific polypeptides and genomic RNA during the replicative cycle of Pichinde virus [PDF]
Journal of Virology, 1982 A stock of plaque-purified Pichinde virus, prepared under conditions designed to limit the amounts of defective interfering virus, was used to infect BHK cells. At daily intervals after infection, cells were examined for infectious and radiolabeled virus particle production and for the synthesis of virus-specific polypeptides.
K, Dimock +4 more
openaire +2 more sources
Expression and Purification of Z Protein from Junín Virus
BioMed Research International, Volume 2010, Issue 1, 2010., 2010 Arenaviridae comprises 23 recognized virus species with a bipartite ssRNA genome and an ambisense coding strategy. The virions are enveloped and include nonequimolar amounts of each genomic RNA species, designated L and S, coding for four ORFs (N, GPC, L, and Z).
S. E. Goñi +11 more
wiley +1 more source
A Systems Biology Starter Kit for Arenaviruses
Viruses, 2012 Systems biology approaches in virology aim to integrate viral and host biological networks, and thus model the infection process. The growing availability of high-throughput “-omics” techniques and datasets, as well as the ever ...
Magali E. Droniou-Bonzom +1 more
doaj +1 more source
Tumor Necrosis Factor and the Pathogenesis of Pichinde Virus Infection in Guinea Pigs [PDF]
The American Society of Tropical Medicine and Hygiene, 1995 Pichinde virus (PIC) is a reticuloendothelial arenavirus of the New World tropics. A guinea pig passage–adapted strain of this virus (adPIC) is uniformly lethal for inbred guinea pigs, while the related, prototype strain (PIC3739) has attenuated virulence.
J F, Aronson, N K, Herzog, T R, Jerrells
openaire +2 more sources
Therapeutic options for human papillomavirus‐positive tonsil and base of tongue cancer
Journal of Internal Medicine, Volume 297, Issue 6, Page 608-629, June 2025.Abstract The incidences of human papillomavirus‐positive (HPV+) tonsillar and base tongue squamous cell carcinomas (TSCC and BOTSCC) have increased in recent decades. Notably, HPV+ TSCC and BOTSCC have a significantly better prognosis than their HPV‐negative counterparts when treated with current surgical options, radiotherapy, or intensified ...
Mark Zupancic +3 more
wiley +1 more source
, 2015 BioMed Research International, Volume 2015, Issue 1, 2015.
Joseph W. Golden +3 more
wiley +1 more source
Viral Infection: A Potent Barrier to Transplantation Tolerance
Journal of Immunology Research, Volume 2008, Issue 1, 2008., 2008 Transplantation of allogeneic organs has proven to be an effective therapeutic for a large variety of disease states, but the chronic immunosuppression that is required for organ allograft survival increases the risk for infection and neoplasia and has direct organ toxicity.
David M. Miller +4 more
wiley +1 more source
Use of recombinant adenovirus vectored consensus IFN-α to avert severe arenavirus infection.
PLoS ONE, 2011 Several arenaviruses can cause viral hemorrhagic fever, a severe disease with case-fatality rates in hospitalized individuals ranging from 15-30%. Because of limited prophylaxis and treatment options, new medical countermeasures are needed for these ...
Brian B Gowen +5 more
doaj +1 more source