Results 41 to 50 of about 979 (130)
Animal Models for the Study of Rodent‐Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Human pathogenic hantaviruses and arenaviruses are maintained in nature by persistent infection of rodent carrier populations. Several members of these virus groups can cause significant disease in humans that is generically termed viral hemorrhagic fever (HF) and is characterized as a febrile illness with an increased propensity to cause acute ...
Joseph W. Golden +4 more
wiley +1 more source
The Regulatory Role of Activating Transcription Factor 2 in Inflammation
Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014 Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA‐binding proteins and is widely distributed in tissues including the liver, lung, spleen, and kidney. Like c‐Jun and c‐Fos, ATF2 responds to stress‐related stimuli and may thereby influence cell proliferation, inflammation, apoptosis, oncogenesis, neurological ...
Tao Yu +14 more
wiley +1 more source
Family‐Specific Degenerate Primer Design: A Tool to Design Consensus Degenerated Oligonucleotides
Biotechnology Research International, Volume 2013, Issue 1, 2013., 2013 Designing degenerate PCR primers for templates of unknown nucleotide sequence may be a very difficult task. In this paper, we present a new method to design degenerate primers, implemented in family‐specific degenerate primer design (FAS‐DPD) computer software, for which the starting point is a multiple alignment of related amino acids or nucleotide ...
Javier Alonso Iserte +6 more
wiley +1 more source
Characterization Studies of the Pichinde Virus--a Member of the Arenavirus Group
Experimental Biology and Medicine, 1971 SummaryPichinde virus, a virus capable of producing a chronic infection, was found to replicate in Vero cells and to form plaques in these cells. The virus had a latent period of approximately 8 hr and maximum titers were reached by 24 to 36 hr after infection.
K, Mifune, M, Carter, W, Rawls
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Variation Between Strains of Hamsters in the Lethality of Pichinde Virus Infections [PDF]
Infection and Immunity, 1977 Infection by Pichinde virus, a member of the arenavirus group, was studied in Golden Syrian hamsters ( Mesocricetus auratus ) with regard to possible mechanisms of resistance to virus infection in adult hamsters. Two hamster strains were found to differ in their susceptibility to lethal Pichinde virus infection. LVG/
M J, Buchmeier, W E, Rawls
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Journal of Parasitology Research, Volume 2012, Issue 1, 2012., 2012 Leishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. The poor activation of an effective cellular response is correlated with the ability of these parasites to infect mononuclear phagocytic cells without triggering their activation ...
Joao Luiz Mendes Wanderley +4 more
wiley +1 more source
Isolation of Ribosome-like Structures from Pichinde Virus
Journal of General Virology, 1975 Three classes of mamalian ribosome-like structures were found to be associated with purified Pichinde virus preparations. These structures, possessing sedimentation coefficients of 80S, 60S and 40S, were sensitive to EDTA dissociation and possessed a buoyant density in caesium chloride of 1-61 g/ml, a value analogous to that displayed by BHK21 cell ...
F E, Farber, W E, Rawls
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Advances in Virology, Volume 2011, Issue 1, 2011., 2011 Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus‐host interactions and associated disease.
Shuzo Urata +2 more
wiley +1 more source
Interferon alfacon-1 protects hamsters from lethal pichinde virus infection. [PDF]
Antimicrob Agents Chemother, 2005 ABSTRACT Hemorrhagic fever of arenaviral origin is a frequently fatal infectious disease of considerable priority to the biodefense mission. Historically, the treatment of arenaviral infections with alpha interferons has not yielded favorable results.
Gowen BB +9 more
europepmc +5 more sources
Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development
BioMed Research International, Volume 2010, Issue 1, 2010., 2010 Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure. The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential returns for industry. However, a number of tools, from
Gavin C. Bowick +2 more
wiley +1 more source