Results 21 to 30 of about 979 (130)

Structural Proteins of Pichinde Virus [PDF]

Journal of Virology, 1972
Pichinde virus, a member of the arenovirus group, was found to have four polypeptides by polyacrylamide gel electrophoresis. Two components, V I and V II , had molecular weights of about 72,000, whereas V III had a molecular weight of 34,000. A minor component, V
B A, Ramos, R J, Courtney, W E, Rawls
openaire   +2 more sources

Characterization of Nucleic Acid of Pichinde Virus [PDF]

Journal of Virology, 1973
The nucleic acid of Pichinde virus was found to be single-stranded ribonucleic acid (RNA) as determined by sensitivity to ribonuclease, by alkaline degradation, by buoyant density in cesium sulfate, and by analysis of the base composition.
M F, Carter, N, Biswal, W E, Rawls
openaire   +2 more sources

Arenaviruses: Old viruses present new solutions for cancer therapy

Frontiers in Immunology, 2023
Viral-based cancer therapies have tremendous potential, especially in the context of treating poorly infiltrated cold tumors. However, in tumors with intact anti-viral interferon (IFN) pathways, while some oncolytic viruses induce strong innate and ...
Paweł Stachura, Paweł Stachura, Olivia Stencel, Zhe Lu, Arndt Borkhardt, Aleksandra A. Pandyra   +5 more
doaj   +1 more source

Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production

Frontiers in Microbiology, 2020
Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo, Patrick I. Mpingabo, Shuzo Urata, Shuzo Urata, Jiro Yasuda, Jiro Yasuda, Jiro Yasuda   +6 more
doaj   +1 more source

Characterization of the Glycoprotein Stable Signal Peptide in Mediating Pichinde Virus Replication and Virulence. [PDF]

J Virol, 2016
ABSTRACT Arenaviruses can cause lethal hemorrhagic fevers in humans with few preventative and therapeutic measures. The arenaviral glycoprotein stable signal peptide (SSP) is unique among signal peptides in that it is an integral component of the mature glycoprotein complex (GPC) and plays important roles not only in GPC ...
Shao J, Liu X, Ly H, Liang Y.
europepmc   +4 more sources

How age and infection history shape the antigen‐specific CD8+ T‐cell repertoire: Implications for vaccination strategies in older adults

Aging Cell, Volume 19, Issue 11, November 2020., 2020
In this review, we aim to provide insight in the maintenance of antigen‐experienced CD8+ T‐cell clones during life. We describe what is already known on the effect of age on the virus‐specific T‐cell repertoire and discuss the contribution of infection history in shaping the repertoire.
Josien Lanfermeijer, José A. M. Borghans, Debbie van Baarle   +2 more
wiley   +1 more source

Characterization of bi-segmented and tri-segmented recombinant Pichinde virus particles. [PDF]

J Virol
ABSTRACT Mammarenaviruses include several highly virulent pathogens (e.g., Lassa virus) capable of causing severe hemorrhagic fever diseases for which there are no approved vaccines and limited treatment options. Mammarenaviruses are enveloped, bi-segmented ambisense RNA viruses.
Murphy H, Huang Q, Jensen J, Weber N, Mendonça L, Ly H, Liang Y.   +6 more
europepmc   +3 more sources

Development of real-time reverse transcriptase qPCR assays for the detection of Punta Toro virus and Pichinde virus. [PDF]

Virol J, 2016
Research with high biocontainment pathogens such as Rift Valley fever virus (RVFV) and Lassa virus (LASV) is expensive, potentially hazardous, and limited to select institutions. Surrogate pathogens such as Punta Toro virus (PTV) for RVFV infection and Pichinde virus (PICV) for LASV infection allow research to be performed under more permissive BSL-2 ...
Stefan CP, Chase K, Coyne S, Kulesh DA, Minogue TD, Koehler JW.   +5 more
europepmc   +3 more sources

Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. [PDF]

PLoS Neglected Tropical Diseases, 2011
Lassa and Junín viruses are the most prominent members of the Arenaviridae family of viruses that cause viral hemorrhagic fever syndromes Lassa fever and Argentine hemorrhagic fever, respectively.
Michelle Mendenhall, Andrew Russell, Donald F Smee, Jeffery O Hall, Ramona Skirpstunas, Yousuke Furuta, Brian B Gowen   +6 more
doaj   +1 more source

Development and Characterization of a Novel Non-Lytic Cancer Immunotherapy Using a Recombinant Arenavirus Vector Platform

Frontiers in Oncology, 2021
Engineered viral vectors represent a promising strategy to trigger antigen-specific antitumor T cell responses. Arenaviruses have been widely studied because of their ability to elicit potent and protective T cell responses.
Henning Lauterbach, Sarah Schmidt, Kia Katchar, Xiaoping Qing, Corinne Iacobucci, Andy Hwang, Katia Schlienger, Ursula Berka, Josipa Raguz, Sarah Ahmadi-Erber, Timo Schippers, Felix Stemeseder, Daniel D. Pinschewer, Igor Matushansky, Klaus K. Orlinger   +14 more
doaj   +1 more source