Results 21 to 30 of about 1,551 (170)

RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection [PDF]

Frontiers in Immunology, 2021
RIG-I and MDA5 are major cytoplasmic innate-immune sensor proteins that recognize aberrant double-stranded RNAs generated during virus infection to activate type 1 interferon (IFN-I) and IFN-stimulated gene (ISG) expressions to control virus infection ...
Morgan Brisse, Morgan Brisse, Qinfeng Huang, Mizanur Rahman, Da Di, Yuying Liang, Hinh Ly, Hinh Ly   +7 more
doaj   +2 more sources

Proteomic analysis of Pichindé virus infection identifies differential expression of prothymosin-alpha. [PDF]

J Biomed Biotechnol, 2010
The arenaviruses include a number of important pathogens including Lassa virus and Junin virus. Presently, the only treatment is supportive care and the antiviral Ribavirin. In the event of an epidemic, patient triage may be required to more effectively manage resources; the development of prognostic biomarker signatures, correlating with disease ...
Bowick GC, Soman KV, Wang H, Aronson JF, Luxon BA, Lomas LO, Gorenstein DG, Herzog NK.   +7 more
europepmc   +4 more sources

Evaluating Antigen- and Vector-Specific Immune Responses of a Recombinant Pichinde Virus-Based Vaccine Expressing the Lymphocytic Choriomeningitis Virus Nucleoprotein [PDF]

Vaccines
Background: Live viral vector-based vaccines are known to elicit strong immune responses, but their use can be limited by anti-vector immunity. Here, we analyzed the immunological responses of a live-attenuated recombinant Pichinde virus (PICV) vector ...
Michaela Cain, Qinfeng Huang, Shania Sanchez, Hinh Ly, Yuying Liang   +4 more
doaj   +2 more sources

Family-specific degenerate primer design: a tool to design consensus degenerated oligonucleotides [PDF]

Biotechnology Research International, Volume 2013, Issue 1, 2013., 2013
Designing degenerate PCR primers for templates of unknown nucleotide sequence may be a very difficult task. In this paper, we present a new method to design degenerate primers, implemented in family-specific degenerate primer design (FAS-DPD) computer ...
Borio, Cristina Silvia, Ghiringhelli, Pablo Daniel, Goñi, Sandra Elizabeth, Iserte, Javier Alonso, Lozano, Mario Enrique, Stephan, Betina Inés   +5 more
core   +4 more sources

Interferon alfacon-1 protects hamsters from lethal pichinde virus infection. [PDF]

Antimicrob Agents Chemother, 2005
ABSTRACT Hemorrhagic fever of arenaviral origin is a frequently fatal infectious disease of considerable priority to the biodefense mission. Historically, the treatment of arenaviral infections with alpha interferons has not yielded favorable results.
Gowen BB, Barnard DL, Smee DF, Wong MH, Pace AM, Jung KH, Winslow SG, Bailey KW, Blatt LM, Sidwell RW.   +9 more
europepmc   +5 more sources

Characterization of bi-segmented and tri-segmented recombinant Pichinde virus particles. [PDF]

J Virol
ABSTRACT Mammarenaviruses include several highly virulent pathogens (e.g., Lassa virus) capable of causing severe hemorrhagic fever diseases for which there are no approved vaccines and limited treatment options. Mammarenaviruses are enveloped, bi-segmented ambisense RNA viruses.
Murphy H, Huang Q, Jensen J, Weber N, Mendonça L, Ly H, Liang Y.   +6 more
europepmc   +3 more sources

Recombinant Tri-Segmented Pichinde Virus as a Novel Live Viral Vaccine Platform. [PDF]

Methods Mol Biol, 2017
Pichinde virus (PICV) is a nonpathogenic arenavirus with a bi-segmented RNA genome (L and S segments) that encodes four viral genes. We have developed a reverse genetics system to generate recombinant tri-segmented PICV (rP18tri) that packages three RNA segments (L, S1, and S2) and can encode up to two foreign genes.
Dhanwani R, Ly H, Liang Y.
europepmc   +4 more sources

Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment [PDF]

Journal for ImmunoTherapy of Cancer
Background Engineered arenavirus vectors have recently been developed to leverage the body’s immune system in the fight against chronic viral infections and cancer. Vectors based on Pichinde virus (artPICV) and lymphocytic choriomeningitis virus (artLCMV)
Pedro Berraondo, Catarina Pinto, Sarah Schmidt, Henning Lauterbach, Timo Schippers, Josipa Raguz, Theresa Pölzlbauer, Mohamed Habbeddine, Sandra Rosskopf, Judith Strauß, Valentin Just, Katell Bidet Huang, Felix Stemeseder, Ethan Stewart, Jakub Jez, Klaus K. Orlinger   +15 more
doaj   +2 more sources

Evaluating the Biological Role of Lassa Viral Z Protein-Mediated RIG-I Inhibition Using a Replication-Competent Trisegmented Pichinde Virus System in an Inducible RIG-IN Expression Cell Line. [PDF]

J Virol, 2022
Di D, Huang Q, Ly H, Liang Y.
europepmc   +2 more sources

Characterization of Virus Specific Polypeptides During Pichinde Virus Infection in Cell Culture [PDF]

, 1982
Several aspects of the replication of Pichinde virus, a member of the arenavirus group, were studied in in vitro cell culture. The major emphasis in the study was the identification and characterization of Pichinde virus encoded polypeptides expressed in
Harnish, Godfrey Delsworth
core   +2 more sources